CAS 2203-97-6: Hydrocortisone hemisuccinate
Description:Hydrocortisone hemisuccinate is a synthetic derivative of hydrocortisone, classified as a corticosteroid. It is primarily used for its anti-inflammatory and immunosuppressive properties. The substance is characterized by its esterification of hydrocortisone with succinic acid, which enhances its solubility and bioavailability, making it suitable for parenteral administration. Hydrocortisone hemisuccinate exhibits a white to off-white crystalline appearance and is typically soluble in water and alcohol, facilitating its use in various pharmaceutical formulations. Its mechanism of action involves the modulation of gene expression and inhibition of pro-inflammatory cytokines, thereby reducing inflammation and immune responses. This compound is often utilized in clinical settings for the treatment of conditions such as adrenal insufficiency, allergic reactions, and certain autoimmune disorders. As with other corticosteroids, it may have side effects, including potential impacts on metabolism, immune function, and electrolyte balance, necessitating careful monitoring during therapy. Overall, hydrocortisone hemisuccinate serves as an important therapeutic agent in managing inflammatory and autoimmune conditions.
Formula:C25H34O8
InChI:InChI=1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1
InChI key:InChIKey=VWQWXZAWFPZJDA-CGVGKPPMSA-N
SMILES:O=C(O)CCC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C
- Synonyms:
- (11β)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregn-4-ene-3,20-dione
- 11b,17a,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate
- 4-{[(11Beta)-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl]Oxy}-4-Oxobutanoic Acid
- 4-{[(8Xi,9Xi,11Beta,14Xi)-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl]Oxy}-4-Oxobutanoic Acid
- Cortisol 21-hemisuccinate
- Cortisol hemisuccinate
- Cortisol succinate
- Cortisol, 21-(hydrogen succinate)
- Cortisol, hydrogen succinate
- Hydrocortisone 21-(Hydrogen Succinate)
- See more synonyms
- Hydrocortisone 21-O-β-carbonylpropionic acid
- Hydrocortisone 21-hemisuccinate
- Hydrocortisone 21-succinate
- Hydrocortisone Hemisuccinate
- Hydrocortisone Succinate
- Hydrocortisone hydrogen succinate
- NSC 7576
- Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11β)-
- Saxizon
