CAS 254435-95-5: [D-MeAla]3-[EtVal]4-cyclosporin A

Description:[D-MeAla]3-[EtVal]4-cyclosporin A is a synthetic derivative of cyclosporin A, which is a cyclic peptide known for its immunosuppressive properties. This compound features modifications in its amino acid sequence, specifically incorporating D-methyl alanine (D-MeAla) and ethyl valine (EtVal) residues. These modifications can enhance the drug's pharmacological profile, potentially improving its efficacy and reducing side effects compared to the parent compound. The structure of this substance includes a cyclic arrangement of amino acids, which contributes to its stability and biological activity. As with other cyclosporins, it functions primarily by inhibiting T-cell activation, making it valuable in organ transplantation and autoimmune disease management. The unique characteristics of [D-MeAla]3-[EtVal]4-cyclosporin A may also influence its solubility, bioavailability, and interaction with cellular targets, which are critical factors in its therapeutic application. Overall, this compound represents a tailored approach to enhancing the properties of traditional immunosuppressants.

Formula:C₆₃H₁₁₃N₁₁O₁₂