CAS 839706-07-9

Formel: C28H24F3N7O2

InChl: InChI=1S/C28H24F3N7O2/c1-16-7-9-21(34-25(39)18-5-4-6-20(11-18)28(29,30)31)12-23(16)38-15-19-13-33-26(36-24(19)37(3)27(38)40)35-22-10-8-17(2)32-14-22/h4-14H,15H2,1-3H3,(H,34,39)(H,33,35,36)

InChI Key: SZNYUUZOQHNEKB-UHFFFAOYSA-N

SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CN=C(C=C5)C

GNF-7

CAS: 839706-07-9

GNF-7

Formel: C₂₈H₂₄F₃N₇O₂

Reinheit: 99.5%

Molekulargewicht: 547.53

Ref: 54-BUP03705

N-[3-[1,4-Dihydro-1-Methyl-7-[(6-Methyl-3-Pyridinyl)Amino]-2-Oxopyrimido[4,5-D]Pyrimidin-3(2H)-Yl]-4-Methylphenyl]-3-(Trifluoromethyl)-

CAS: 839706-07-9

N-[3-[1,4-Dihydro-1-Methyl-7-[(6-Methyl-3-Pyridinyl)Amino]-2-Oxopyrimido[4,5-D]Pyrimidin-3(2H)-Yl]-4-Methylphenyl]-3-(Trifluoromethyl)-

Formel: C₂₈H₂₄F₃N₇O₂

Reinheit: 98%

Molekulargewicht: 547.54

Ref: 54-PC108459

N-(4-Methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide

CAS: 839706-07-9

Formel: C₂₈H₂₄F₃N₇O₂

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 547.5311

Ref: IN-DA00G3SD

N-(4-Methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide

CAS: 839706-07-9

N-(4-Methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide

Formel: C₂₈H₂₄F₃N₇O₂

Reinheit: 98+%

Molekulargewicht: 547.53

Ref: IN-DG300779

GNF-7

CAS: 839706-07-9

GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.

Formel: C₂₈H₂₄F₃N₇O₂

Reinheit: 97.05% - 99.7%

Farbe und Form: Solid

Molekulargewicht: 547.53

Ref: TM-T3196

BenzaMide, N-[3-[1,4-dihydro-1-Methyl-7-[(6-Methyl-3-pyridinyl)aMino]-2-oxopyriMido[4,5-d]pyriMidin-3(2H)-yl]-4-Methylphenyl]-3-(trifluoroMethyl)-

CAS: 839706-07-9

Reinheit: 98+%

Molekulargewicht: 547.5419922

Ref: 10-F863747

GNF-7

CAS: 839706-07-9

GNF-7 is a molecule that inhibits the bcr-abl kinase, which plays a key role in chronic myelogenous leukemia (CML) and some other cancers. GNF-7 binds to the ATP binding site of the bcr-abl kinase, inhibiting its activity. It also induces caspase-independent cell death by hydrogen bond interactions with amino acids in the ATP binding site. The study has shown that GNF-7 is effective on monocytes, myeloid leukemia cells, and inflammatory bowel disease cells. GNF-7 is a small molecule that can be synthesized by chemical methods and is thus cheaper than many other cancer drugs.

Formel: C₂₈H₂₄F₃N₇O₂

Reinheit: Min. 95%

Molekulargewicht: 547.53 g/mol

Ref: 3D-PIB70607