CAS 1401-69-0

Tilosina

Descripción:

Tilosina es un antibiótico macrólido utilizado principalmente en medicina veterinaria, particularmente para ganado y aves de corral, para tratar infecciones bacterianas y promover el crecimiento. Se deriva de la bacteria *Streptomyces fradiae* y exhibe un amplio espectro de actividad contra bacterias Gram-positivas y algunas Gram-negativas. Tilosina funciona inhibiendo la síntesis de proteínas en las bacterias, evitando así su crecimiento y reproducción. La sustancia se administra típicamente en forma de su sal de tartrato, que mejora su solubilidad. Tilosina es conocido por su relativamente baja toxicidad en animales, pero su uso está regulado en animales productores de alimentos para prevenir residuos de antibióticos en productos cárnicos. Además, se ha estudiado por sus posibles aplicaciones en acuicultura y como aditivo alimentario. Su estructura química presenta un gran anillo de lactona, característico de los macrólidos, que contribuye a sus propiedades antibacterianas. Al igual que con muchos antibióticos, la aparición de resistencia es una preocupación, lo que requiere una gestión cuidadosa de su uso en prácticas agrícolas.

Fórmula:C₄₆H₇₇NO₁₇

InChI:InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18+/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-/m1/s1

Clave InChI:InChIKey=WBPYTXDJUQJLPQ-VMXQISHHSA-N

SMILES:O([C@H]1[C@H](N(C)C)[C@@H](O)[C@H](O[C@H]2[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(/C)=C/[C@H](CO[C@H]3[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O3)[C@@H](CC)OC(=O)C[C@@H](O)[C@@H]2C)O[C@@H]1C)[C@H]4C[C@@](C)(O)[C@@H](O)[C@H](C)O4

Sinónimos:

Fradizine
Oxacyclohexadeca-11,13-diene-7-acetaldehyde, 15-[[(6-deoxy-2,3-di-O-methyl-β-<span class="text-smallcaps">D</smallcap>-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-<smallcap>L</smallcap>-ribo-hexopyranosyl)-3-(dimethylamino)-β-<smallcap>D</span>-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxo-, [4R-(4R*,5S*,6S*,7R*,9R*,11E,13E,15R*,16R*)]-
Oxacyclohexadeca-11,13-diene-7-acetaldehyde, 15-[[(6-deoxy-2,3-di-O-methyl-β-D-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxo-, [4R-(4R*,5S*,6S*,7R*,9R*,11E,13E,15R*,16R*)]-
Oxacyclohexadecane, tylosin deriv.
Tilan
Tilosina
Tylocine
Tylosin A
Tylosin base
Tylosine
Vubityl 200
[(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-3-(dimethylamino)-beta-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-beta-D-allopyranoside
[(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-galactopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-D-allopyranoside
[(2R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-3-(dimethylamino)-beta-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-beta-D-allopyranoside
[(2R,4E,6E,9R,11R,12S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-D-allopyranoside
[4R-(4R*,5S*,6S*,7R*,9R*,11E,13E,15R*,16R*)]-15-[[(6-Deoxy-2,3-di-O-methyl-β-<span class="text-smallcaps">D</smallcap>-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-<smallcap>L</smallcap>-ribo-hexopyranosyl)-3-(dimethylamino)-β-<smallcap>D</span>-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-diene-7-acetaldehyde
[4R-(4R*,5S*,6S*,7R*,9R*,11E,13E,15R*,16R*)]-15-[[(6-Deoxy-2,3-di-O-methyl-β-D-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-diene-7-acetaldehyde
Ver más sinónimos

CAS 1401-69-0

Tilosina

TYLOSIN CRS

Ref: 41-T2880000

Tylosin

Ref: 47-349

FIRST INTERNATIONAL STANDARD FOR TYLOSIN

Ref: 41-ISA_TYN

Tylosin

Ref: 54-OR1029875

Tylosin

Ref: 7W-GA0812

Tylosin

Ref: 4Z-T-175001

Tylosin

Ref: TM-T1003

Tylosin

Ref: 54-BUP14011

Tylosin-d3

Ref: 4Z-T-175002

Tylosin (Standard)

Ref: TM-TMSM-2358

Tylosin

Ref: IN-DA00HVQN

Tylosin A 100 µg/mL in Acetonitrile

Ref: 04-A17895615AL-100

GB 31660.1-2019 Macrolide Antibiotics Mixture 167 100 µg/mL in Methanol

Ref: 04-A50000167ME

Tylosin-d3

Ref: TR-T947652

Tylosin

Ref: TR-T947650

Ref: IN-DG156097

Tylosin

Ref: BE-BePure-26535

Tylosin in Methanol

Ref: BE-BePure-26535YM-1000

Tylosin in Methanol

Ref: BE-BePure-26535XM-100

Tylosin

Ref: 10-F951543