CAS 163680-77-1

Metanosulfonato de pazufloxacina

Descripción:

El metanosulfonato de pazufloxacina es un antibiótico fluoroquinolona sintético caracterizado por su actividad antibacteriana de amplio espectro. Se utiliza principalmente en el tratamiento de diversas infecciones bacterianas, particularmente aquellas causadas por organismos Gram-negativos y algunos Gram-positivos. El compuesto exhibe un mecanismo de acción que implica la inhibición de la girasa del ADN bacteriano y la topoisomerasa IV, enzimas críticas para la replicación y transcripción del ADN. La pazufloxacina es conocida por sus favorables propiedades farmacocinéticas, que incluyen una buena biodisponibilidad oral y penetración en los tejidos, lo que mejora su eficacia terapéutica. La forma de sal de metanosulfonato mejora su solubilidad y estabilidad, haciéndola adecuada para la formulación en diversas formas de dosificación. Además, se ha estudiado la pazufloxacina por su posible uso en el tratamiento de infecciones del tracto respiratorio y del tracto urinario. Al igual que otros fluoroquinolonas, puede estar asociada con efectos secundarios, incluidos trastornos gastrointestinales y posibles efectos en la salud de los tendones. En general, el metanosulfonato de pazufloxacina representa una opción valiosa en el arsenal de antibióticos, particularmente en el contexto del aumento de la resistencia a los antibióticos.

Fórmula: C₁₇H₁₉FN₂O₇S

InChI: InChI=1/C16H15FN2O4.CH4O3S/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22;1-5(2,3)4/h4-5,7H,2-3,6,18H2,1H3,(H,21,22);1H3,(H,2,3,4)/t7-;/m0./s1

Clave InChI: InChIKey=UDHGFPATQWQARM-FJXQXJEOSA-N

SMILES: O=C1C=2C3=C(C(=C(F)C2)C4(N)CC4)OC[C@H](C)N3C=C1C(O)=O.S(C)(=O)(=O)O

Sinónimos:

• (3S)-10-(1-Aminocyclopropyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid Methanesulfonate
• (3S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonate
• (S)-(-)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-, monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, monomethanesulfonate (9CI)
• Pasil
• Pazucross
• Pazufloxacin Mesilate
• Pazufloxacin Mesylate
• Pazufloxacin Methanesulfonate
• T 3762
• (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid,
• Pazufloxacin mesilate VETRANAL
• pazufloxaxin methanesulfonate
• Pazufloxacin Monomethanesulfonate
• 2,3-de)-1,4-benzoxazine-6-carboxylicacid,2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-7h-pyrido((s)-7h-pyrido(monomethanesulfonate
• (s)-yclopropyl)-9-fluoro-3-methyl-7-oxomonomethanesulfonate
• (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid, T-3761,
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate (9CI)
• Pazufloxacin mesylate, Pazufloxacin methanesulfonate
• PAZUFLOXAXIN METHANESULFONATE 99%

Pazufloxacin Mesylate

CAS: 127045-41-4, 163680-77-1

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Orange to Green powder to crystal

Peso molecular: 414.40

Ref: 3B-P1962

(2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5,7,9(13),11-tetraene-11-carboxylic acid; methanesulfonic acid

CAS: 163680-77-1

Fórmula: C₁₇H₁₉FN₂O₇S

Pureza: 98%

Forma y color: Solid

Peso molecular: 414.4054

Ref: IN-DA001UB2

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate (T-3762) is a fluoroquinolone antibiotic.

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Pureza: 99.88% - 99.93%

Forma y color: Crystalline Solid

Peso molecular: 414.4

Ref: TM-T1620

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate

Pureza: ≥98%

Peso molecular: 414.4g/mol

Ref: 54-BUP14927

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate

Pureza: 98%

Peso molecular: 414.4g/mol

Ref: 54-PC109200

Pazufloxacin Mesylate

CAS: 163680-77-1

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Forma y color: White To Off-White Solid

Peso molecular: 318.31 96.11

Ref: 4Z-P-198001

PAZUFLOXACIN MESILATE

CAS: 163680-77-1

Pureza: 95%

Peso molecular: 414.399993896484

Ref: 10-F806744

Pazufloxacin mesylate

CAS: 163680-77-1

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Forma y color: Neat

Peso molecular: 414.41

Ref: 04-C15896350

Pazufloxacin mesylate

CAS: 163680-77-1

Fórmula: C₁₆H₁₅FN₂O₄·CH₄SO₃

Peso molecular: 414.41

Ref: 7W-GA7060

Pazufloxacin Mesilate RS

CAS: 163680-77-1

Forma y color: White To Pale Yellow-White Solid Crystalline Powder

Ref: 2K-1112800021

Pazufloxacin mesylate

CAS: 163680-77-1

Pazufloxacin mesylate is an antimicrobial agent that inhibits bacterial growth by binding to bacterial DNA gyrase and topoisomerase IV. Pazufloxacin mesylate has been shown to have a synergistic effect with other antibiotics. It has been shown to be effective against a number of human pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae. Pazufloxacin mesylate is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. The inhibition of cell division by pazufloxacin mesilate may be due to the inhibition of rna synthesis and protein synthesis. This antibiotic also causes a decrease in locomotor activity in mice, which may be due to its ability to inhibit the release of inflammatory mediators

Fórmula: C₁₇H₁₉FN₂O₇S

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 414.41 g/mol

Ref: 3D-FP26772

Pazufloxacin Mesylate

Producto controlado

CAS: 163680-77-1

Applications A fluorinated quinolone antibiotic. Antibacterial.
References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Forma y color: Neat

Peso molecular: 414.41

Ref: TR-P211000