CAS 4419-39-0

Beclometasona

Descripción:

Beclometasona es un corticosteroide sintético utilizado principalmente por sus propiedades antiinflamatorias e inmunosupresoras. Se administra comúnmente en forma de inhaladores, aerosoles nasales o formulaciones tópicas para tratar condiciones como el asma, la rinitis alérgica y varios trastornos de la piel. La sustancia funciona inhibiendo la liberación de mediadores inflamatorios, reduciendo así la hinchazón y la irritación en los tejidos afectados. Beclometasona tiene una biodisponibilidad sistémica relativamente baja cuando se inhala, lo que minimiza los efectos secundarios potenciales en comparación con los corticosteroides sistémicos. Su estructura química presenta un esqueleto esteroide con grupos funcionales específicos que contribuyen a su potencia y selectividad por los receptores de glucocorticoides. El compuesto generalmente es bien tolerado, aunque el uso a largo plazo puede llevar a efectos secundarios como supresión adrenal o irritación local. Al igual que con cualquier medicamento, es esencial usar Beclometasona bajo supervisión médica para garantizar una dosificación adecuada y monitorear cualquier efecto adverso.

Fórmula: C₂₂H₂₉ClO₅

InChI: InChI=1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

Clave InChI: InChIKey=NBMKJKDGKREAPL-DVTGEIKXSA-N

SMILES: Cl[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]

Sinónimos:

• (11β,16β)-9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• (8S,10S,11S,13S,16S)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• 4419-39-0
• 9-Chloro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Diene-17,21-Diyl Dipropanoate
• 9-Chloro-11β,17,21-trihydroxy-16β-methyl-pregna-1,4-diene-3,20-dione
• 9-Chloro-16β-methylprednisolone
• 9α-Chloro-16β-methylprednisolone
• Beclometason
• Beclometasona
• Beclometasone
• Beclometasone 17,21-Dipropionate
• Becolvent
• Pregna-1,4-diene-3,20-dione, 9-chloro-11,17,21-trihydroxy-16-methyl-, (11β,16β)-

Beclomethasone (9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione)

CAS: 4419-39-0

Halogenated derivatives of adrenal cortical hormones

Fórmula: C₂₂H₂₉ClO₅

Forma y color: White Powder

Peso molecular: 408.17035

Ref: 45-1A10350

Beclomethasone

CAS: 4419-39-0

Fórmula: C₂₂H₂₉ClO₅

Peso molecular: 408.92

Ref: 7W-GL1939

Beclometasone (Beclomethasone)

CAS: 4419-39-0

Fórmula: C₂₂H₂₉ClO₅

Forma y color: White To Off-White Solid

Peso molecular: 408.92

Ref: 4Z-B-236

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

Producto controlado

CAS: 105102-22-5, 1177-87-3, 124-94-7, 13609-67-1, 14484-47-0, 1524-88-5, 2135-17-3, 2152-44-5, 25122-46-7, 25122-57-0, 3093-35-4, 33564-31-7, 356-12-7, 378-44-9, 3801-06-7, 3870-07-3, 426-13-1, 4419-39-0, 50-02-2, 50-03-3, 50-04-4, 50-23-7, 50-24-8, 51022-69-6, 51333-22-3, 514-36-3, 53-06-5, 5534-09-8, 5593-20-4, 57524-89-7, 66734-13-2, 67-78-7, 73771-04-7, 76-25-5, 80474-14-2, 83-43-2, 987-24-6

Forma y color: Mixture

Ref: 04-A50000094ME

9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Beclometasone)

Producto controlado

CAS: 4419-39-0

Fórmula: C₂₂H₂₉ClO₅

Forma y color: Neat

Peso molecular: 408.92

Ref: 86-MM0199.03

Beclometasone

Producto controlado

CAS: 4419-39-0

Fórmula: C₂₂H₂₉ClO₅

Forma y color: Neat

Peso molecular: 408.92

Ref: 04-C10429000

Beclometasone

CAS: 4419-39-0

Beclometasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma.

Fórmula: C₂₂H₂₉ClO₅

Pureza: 99.41% - 99.68%

Forma y color: White To Off-White Crystalline Powder

Peso molecular: 408.92

Ref: TM-T8777

Beclomethasone

Producto controlado

CAS: 4419-39-0

Stability Hygroscopic
Applications Glucocorticoid. Used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant). Anti-inflammatory (topical).
References Malfitan, V.A., et al.: Clin. Ther., 4, 472 (1982), Rao, M., et al.: J. Asthma, 19, 21 (1982), Small, P., et al.: Ann. Allergy, 49, 127 (1982), Brogden, R.N., et al.: Drugs, 28, 99 (1984),

Fórmula: C₂₂H₂₉ClO₅

Forma y color: Off-White

Peso molecular: 408.92

Ref: TR-B131000

Beclomethasone - 98% min

Producto controlado

CAS: 4419-39-0

Beclomethasone is a synthetic glucocorticoid that has significant effects on the bronchial system. It is used for the treatment of bronchial asthma and other diseases of the airways. Beclomethasone may be administered by inhalation, orally, or topically. Beclomethasone binds to cytoplasmic receptors in target cells and inhibits phospholipases, which are enzymes that release arachidonic acid from cell membranes. This process inhibits the production of leukotrienes, prostaglandins, and thromboxanes-all compounds that have been implicated in inflammation and bronchial asthma. The pharmacokinetic profile of Beclomethasone includes a high volume of distribution and low protein binding. Beclomethasone has been shown to inhibit nuclear receptors such as PPARα and GR, which regulate gene transcription for lipid metabolism.

Fórmula: C₂₂H₂₉ClO₅

Pureza: Min. 95 Area-%

Forma y color: White Powder

Peso molecular: 408.92 g/mol

Ref: 3D-FB18151

Beclomethasone - 95% min

Producto controlado

CAS: 4419-39-0

Beclomethasone is a synthetic glucocorticoid that has been approved for the treatment of asthma and inflammatory bowel disease. It reduces inflammation by suppressing the immune system response. Beclomethasone has also been used in clinical studies to treat bronchial, bowel disease, and natriuretic effects due to its ability to increase magnesium levels in the body. Clinical trials have shown that beclomethasone can be used as an effective therapy for asthma. This drug also has anti-inflammatory properties and may be useful in treating infectious diseases such as tuberculosis. Beclomethasone has been shown to be effective against many different types of bacteria including Mycobacterium tuberculosis and Streptococcus pneumoniae.

Fórmula: C₂₂H₂₉ClO₅

Pureza: Min. 95 Area-%

Forma y color: White Powder

Peso molecular: 408.92 g/mol

Ref: 3D-FB164756