CAS 81-81-2

(±)-Warfarina

Descripción:

(±)-Warfarina es un anticoagulante sintético comúnmente utilizado en la prevención y tratamiento de trastornos tromboembólicos. Funciona inhibiendo la epóxido reductasa de vitamina K, que es esencial para la síntesis de factores de coagulación dependientes de vitamina K en el hígado. Este compuesto existe como una mezcla racémica de dos enantiómeros, R y S, siendo el enantiómero S significativamente más potente como anticoagulante. La warfarina se caracteriza por su relativamente baja solubilidad en agua, pero es soluble en disolventes orgánicos, lo que facilita su formulación en varias preparaciones farmacéuticas. La sustancia tiene una fórmula molecular de C19H16O4 y un peso molecular de aproximadamente 308.34 g/mol. Su farmacocinética implica administración oral, con un inicio de acción retrasado debido al tiempo requerido para que los factores de coagulación existentes disminuyan. La warfarina está sujeta a una variabilidad interindividual significativa en la dosificación debido a factores como polimorfismos genéticos, ingesta dietética de vitamina K e interacciones con otros medicamentos, lo que requiere un monitoreo cuidadoso de los parámetros de coagulación durante la terapia.

Fórmula: C₁₉H₁₆O₄

InChI: InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3

Clave InChI: InChIKey=PJVWKTKQMONHTI-UHFFFAOYSA-N

SMILES: C(CC(C)=O)(C1=C(O)C=2C(OC1=O)=CC=CC2)C3=CC=CC=C3

Sinónimos:

• (.+-.)-Warfarin
• (.+-.)-Warfarin-alcohol
• (RS)-Warfarin
• 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
• 3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
• 3-(α-Acetonylbenzyl)-4-hydroxycoumarin
• 3-(α-Phenyl-β-acetylethyl)-4-hydroxy-coumarin
• 3-(α-Phenyl-β-acetylethyl)-4-hydroxycoumarin
• 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
• 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
• <span class="text-smallcaps">DL</span>-3-(α-Acetonylbenzyl)-4-hydroxycoumarin
• Athrombine-K
• Benzopyran(2H-1)-2-One, 4-Hydroxy-3-(3-Oxo-1- Phenylbutyl)-
• Brumolin
• Circuvit
• Co-Rax
• Compound 42
• Coumadin
• Coumafen
• Coumafene
• Coumaphen
• Coumarin, 3-(α-acetonylbenzyl)-4-hydroxy-
• Coumefene
• DL-3-(α-Acetonylbenzyl)-4-hydroxycoumarin
• Dethmor
• Kumader
• Kumadu
• Kumatox
• Martefarin
• Nsc 59813
• Ratron
• Ratron G
• Rodafarin
• Rodafarin C
• Rodex
• Temus W
• Vampirinip II
• Vampirinip III
• W.A.R.F. 42
• WARF compound 42
• Warf 5
• Warf5
• Warfarin acid
• Warfarina
• Warfarine
• Zoocoumarin
• rac-Warfarin

Warfarin Sodium (contains Isopropyl Alcohol)

Producto controlado

CAS: 129-06-6, 81-81-2

Fórmula: C₁₉H₁₅NaO₄

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 330.31

Ref: 3B-W0005

Warfarin, 1mg/ml in Acetonitrile

Producto controlado

CAS: 81-81-2

Forma y color: Single Solution

Ref: LP-WAR-1922-1LA

Warfarin 1.0 mg/ml in Acetonitrile

Producto controlado

CAS: 81-81-2

Forma y color: Single Solution

Ref: 61-AMP0638.00-11

Warfarin

Producto controlado

CAS: 81-81-2

Forma y color: Neat

Ref: 61-FOR0638.00

WARFARIN RS

Producto controlado

CAS: 81-81-2

WARFARIN RS

Fórmula: C₁₀H₁₆O₄

Peso molecular: 200.2316

Ref: 41-ICRS0439

Warfarin

Producto controlado

CAS: 81-81-2

Warfarin

Fórmula: C₁₉H₁₆O₄

Pureza: 99.4%

Forma y color: White

Peso molecular: 308.10486

Ref: 47-672

WARFARIN SODIUM CLATHRATE CRS

Producto controlado

CAS: 81-81-2

WARFARIN SODIUM CLATHRATE CRS

Forma y color: Crystalline Powder. White. Powder.

Ref: 41-Y0000778

Warfarin

Producto controlado

CAS: 81-81-2

Aromatic lactones used as drugs

Fórmula: C₁₉H₁₆O₄

Forma y color: White Colorless Crystals

Peso molecular: 308.33 g/mol

Ref: 45-1719000

Warfarin

Producto controlado

CAS: 81-81-2

Fórmula: C₁₉H₁₆O₄

Forma y color: Off-White Solid

Peso molecular: 308.33

Ref: 4Z-W-015

Warfarin

Producto controlado

CAS: 81-81-2

Fórmula: C₁₉H₁₆O₄

Pureza: ≥ 98.0% (anhydrous basis)

Forma y color: White crystalline powder

Peso molecular: 308.33

Ref: 7W-GP7659

Warfarin

Producto controlado

CAS: 81-81-2

Warfarin

Pureza: ≥98%

Peso molecular: 308.33g/mol

Ref: 54-BUP21913

Warfarin 100 µg/mL in Acetonitrile

Producto controlado

CAS: 81-81-2

Fórmula: C₁₉H₁₆O₄

Forma y color: Single Solution

Peso molecular: 308.33

Ref: 04-XA17940000AL

LC PestiMix 9 10 µg/mL in Acetonitrile

Producto controlado

CAS: 1003318-67-9, 1031756-98-5, 104273-71-4, 105779-78-0, 1072957-71-1, 1101132-67-5, 1207727-04-5, 121451-02-3, 1220411-29-9, 1228284-64-7, 1229654-66-3, 123572-88-3, 1255734-28-1, 1263133-33-0, 130561-48-7, 135186-78-6, 1352994-67-2, 1383809-87-7, 1390661-72-9, 140163-89-9, 1417782-03-6, 1472649-01-6, 147411-69-6, 1486617-22-4, 156963-66-5, 158237-07-1, 162320-67-4, 168088-61-7, 173662-97-0, 188489-07-8, 200509-41-7, 221205-90-9, 224049-04-1, 238410-11-2, 256412-89-2, 283159-90-0, 330459-31-9, 337458-27-2, 352010-68-5, 366815-39-6, 42835-25-6, 447399-55-5, 473278-76-1, 473798-59-3, 494793-67-8, 500207-04-5, 517875-34-2, 56073-07-5, 5836-29-3, 68049-83-2, 688046-61-9, 704886-18-0, 799247-52-2, 81-81-2, 81-82-3, 81334-34-1, 81777-95-9, 82692-44-2, 847749-37-5, 850881-70-8, 862588-11-2, 874195-61-6, 874967-67-6, 875915-78-9, 881685-58-1, 882182-49-2, 902760-40-1, 907204-31-3, 911499-62-2, 915972-17-7, 926914-55-8, 943831-98-9

Forma y color: Mixture

Ref: 04-A50000809AL

Warfarin

Producto controlado

CAS: 81-81-2

Forma y color: Neat

Ref: LP-WAR-1922-10

Warfarin

Producto controlado

CAS: 81-81-2

Fórmula: C₁₉H₁₆O₄

Forma y color: Neat

Peso molecular: 308.33

Ref: 86-MM0638.00

Warfarin

Producto controlado

CAS: 81-81-2

Fórmula: C₁₉H₁₆O₄

Forma y color: Neat

Peso molecular: 308.33

Ref: 04-C17940000

Rodenticides Mixture 248 100 µg/mL in Acetonitrile

Producto controlado

CAS: 28772-56-7, 3691-35-8, 56073-07-5, 56073-10-0, 81-81-2, 82-66-6

Fórmula: C₃₁H₂₃BrO₃

Forma y color: Mixture

Peso molecular: 523.42

Ref: 04-GS09000248AL

Warfarin

Producto controlado

CAS: 81-81-2

Applications Coumarin anticoagulant. Marketed as the racemate; the S-(-)-form is the more potent isomer. Anticoagulant. This compound is a contaminant of emerging concern (CECs).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),

Fórmula: C₁₉H₁₆O₄

Forma y color: Neat

Peso molecular: 308.33

Ref: TR-W498500

Warfarin - 90%

Producto controlado

CAS: 81-81-2

Warfarin is a coumarin that is used as an oral anticoagulant. It has been in use for over 50 years and is still the most widely prescribed drug for the prevention of thromboembolic disease. Warfarin inhibits the synthesis of vitamin K-dependent clotting factors II, VII, IX, and X. This inhibition leads to a prolonged prothrombin time and increased bleeding time. Warfarin also prevents blood from clotting by inhibiting platelet aggregation. The molecular weight of Warfarin is 798 Da, which corresponds to its molecular weight heparin (MWH) binding site.
Warfarin has a narrow therapeutic window and requires careful monitoring by measuring prothrombin time in order to prevent adverse effects such as excessive bleeding or blood clots. Warfarin also interacts with many drugs, including aspirin and non-steroidal anti-inflammatory drugs like ibuprofen, which can lead to increased risk of bleeding

Fórmula: C₁₉H₁₆O₄

Pureza: Min. 95%

Forma y color: White Slightly Brown Clear Liquid

Peso molecular: 308.33 g/mol

Ref: 3D-FW01354

Warfarin

Producto controlado

CAS: 81-81-2

Warfarin (Coumafene) is a vitamin K antagonist, and it works by blocking the action of vitamin K, which is necessary for the synthesis of clotting factors in the liver. Warfarin blocks the action of vitamin K by inhibiting the enzyme gamma-glutamyl carboxylase, which is responsible for the carboxylation of glutamate residues in the clotting factors. This prevents the production of functional clotting factors, leading to an anticoagulant effect.

Fórmula: C₁₉H₁₆O₄

Pureza: 99.35%

Forma y color: Solid

Peso molecular: 308.3279

Ref: TM-T60736