Bcr-Abl
Los inhibidores de Bcr-Abl son terapias dirigidas que inhiben la proteína de fusión Bcr-Abl, formada debido a la translocación del cromosoma Filadelfia y que es un impulsor de la leucemia mieloide crónica (LMC). Esta proteína también influye en la angiogénesis, contribuyendo a la progresión tumoral. Los inhibidores de Bcr-Abl son cruciales en el tratamiento de la LMC y se están explorando por su potencial para inhibir la angiogénesis en varios tipos de cáncer. En CymitQuimica, ofrecemos inhibidores de Bcr-Abl de alta calidad para apoyar su investigación en biología del cáncer, angiogénesis y terapias dirigidas.
Se han encontrado 129 productos para "Bcr-Abl".
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Tyrosine kinase-IN-8
Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI) exhibiting antiproliferative activity against the chronic myeloid leukemia (CML) cell line K562, with a CC50 of 0.8 µM. Tyrosine kinase-IN-8 is applicable for research in chronic leukemia.Fórmula:C31H21F2N7O2Forma y color:SolidPeso molecular:561.17248SIAIS178
CAS:SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).Fórmula:C50H62ClN11O6S2Pureza:98.07%Forma y color:SolidPeso molecular:1012.68P19As
CAS:P19As is a BCR-ABL PROTAC degrader based on Asciminib, with a DC50 of approximately 200 nM for the wild-type BCR-ABL protein. It is capable of degrading the T315I mutant and demonstrates strong antiproliferative activity in BaF3-BCR-ABL (T315I) cells. P19As is applicable for research in chronic myeloid leukemia and acute lymphoblastic leukemia.Fórmula:C47H51ClF2N12O10Peso molecular:1017.45SNIPER(ABL)-049
SNIPER(ABL)-049, a compound that conjugates Imatinib (ABL inhibitor) with Bestatin (IAP ligand) through a linker, effectively reduces BCR-ABL protein levels,Fórmula:C52H66N10O8Pureza:98%Forma y color:SolidPeso molecular:959.14PROTAC BCR-ABL1 ligand 1
CAS:GMB-475 is a PROTAC ligand targeting BCR-ABL1 for degradation via E3 ligase recruitment.Fórmula:C17H12F3N3O2Forma y color:SolidPeso molecular:347.29SNIPER(ABL)-047
SNIPER(ABL)-047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels,Fórmula:C67H82F3N11O9SPureza:98%Forma y color:SolidPeso molecular:1274.5SNIPER(ABL)-058
CAS:SNIPER(ABL)-058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL proteinFórmula:C62H75N11O9SPureza:98%Forma y color:SolidPeso molecular:1150.39SNIPER(ABL)-020
SNIPER(ABL)-020, a Dasatinib-Bestatin conjugate via linker, inhibits ABL and targets IAP, reducing BCR-ABL protein.Fórmula:C44H59ClN10O8SPureza:98%Forma y color:SolidPeso molecular:923.52SNIPER(ABL)-019
SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting aFórmula:C60H77ClN12O9SPureza:98%Forma y color:SolidPeso molecular:1177.85Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidSNIPER(ABL)-024
CAS:SNIPER(ABL)-024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels,Fórmula:C52H61F3N8O9SPureza:98%Forma y color:SolidPeso molecular:1031.15SNIPER(ABL)-015
SNIPER(ABL)-015, a compound that conjugates GNF5 (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 5Fórmula:C58H70F3N9O9Pureza:98%Forma y color:SolidPeso molecular:1094.23SNIPER(ABL)-013
SNIPER(ABL)-013, a compound that links GNF5 (ABL inhibitor) with Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 ofFórmula:C42H52F3N7O8Pureza:98%Forma y color:SolidPeso molecular:839.9Abl Cytosolic Substrate
CAS:Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl ).Fórmula:C64H101N15O16Pureza:98%Forma y color:SolidPeso molecular:1336.58SNIPER(ABL)-050
SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker.Fórmula:C68H84N12O9Pureza:98%Forma y color:SolidPeso molecular:1213.47SNIPER(ABL)-039
CAS:SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 ofFórmula:C54H68ClN11O9S2Pureza:98%Forma y color:SolidPeso molecular:1114.77FGFRs-IN-1
FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.Fórmula:C28H26Cl2N4O3Forma y color:SolidPeso molecular:537.44PROTAC BCR-ABL Degrader-1
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway andFórmula:C43H40N10O6Pureza:98%Forma y color:SolidPeso molecular:792.84SNIPER(ABL)-033
CAS:SNIPER(ABL)-033, a compound that conjugates HG-7-85-01 (ABL inhibitor) to a LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL proteinFórmula:C61H73F3N10O9S2Pureza:98%Forma y color:SolidPeso molecular:1211.42Tyrosine Kinase Inhibitor Library
A unique collection of xnum HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies;Forma y color:Odour Solid
