BTK
Los inhibidores de la tirosina quinasa de Bruton (BTK) son compuestos que específicamente se dirigen e inhiben la BTK, una enzima crucial involucrada en la señalización del receptor de células B y en la regulación de la angiogénesis. La BTK desempeña un papel significativo en la proliferación y supervivencia de las células cancerosas, particularmente en las malignidades hematológicas. Al inhibir la BTK, estos compuestos pueden interrumpir la angiogénesis y el crecimiento tumoral, lo que los convierte en valiosos en la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de BTK de alta calidad para apoyar su investigación en oncología, inmunología y angiogénesis.
Se han encontrado 145 productos de "BTK"
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ARQ 531
CAS:<p>ARQ-531: potent oral BTK inhibitor, anti-cancer potential, IC50 of 0.85/0.39 nM for WT/C481S-BTK.</p>Fórmula:C25H23ClN4O4Pureza:98.68% - 99.63%Forma y color:SolidPeso molecular:478.93AS-1763
CAS:<p>AS-1763 is an orally available and selective BTK inhibitor with an IC50 of 0.85 nM.</p>Fórmula:C33H31FN6O3Pureza:≥95%Forma y color:SolidPeso molecular:578.64Orelabrutinib
CAS:<p>Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).</p>Fórmula:C26H25N3O3Pureza:97.77% - 99.54%Forma y color:SolidPeso molecular:427.49Tirabrutinib hydrochloride
CAS:<p>Tirabrutinib hydrochloride is a potent, highly selective, irreversible oral BTK inhibitor.Cost-effective and quality-assured.</p>Fórmula:C25H23ClN6O3Pureza:99.04% - 99.27%Forma y color:SolidPeso molecular:490.94Rilzabrutinib
CAS:<p>Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).</p>Fórmula:C36H40FN9O3Pureza:98.28% - 99.76%Forma y color:SolidPeso molecular:665.76MT-802
CAS:<p>MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).</p>Fórmula:C41H41N9O8Pureza:95.93% - 97%Forma y color:SolidPeso molecular:787.82Btk inhibitor 2
CAS:<p>Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.</p>Fórmula:C24H25N5O3Pureza:99.94%Forma y color:SolidPeso molecular:431.49IBT6A
CAS:<p>IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.</p>Fórmula:C22H22N6OPureza:99.8% - 99.88%Forma y color:SolidPeso molecular:386.45SJF620 hydrochloride
CAS:<p>SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].</p>Fórmula:C41H45ClN8O7Pureza:98%Forma y color:SolidPeso molecular:797.3FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Forma y color:LiquidDD 03-171
CAS:<p>Potent BTK Degrader, IC50=5.1nM, CRBN-dependent, suppresses MCL; degrades Ibrutinib-resistant BTK, no kinases binding, reduces tumors in models.</p>Fórmula:C55H62N10O8Forma y color:SolidPeso molecular:991.163BTK-IN-5
CAS:<p>BTK-IN-5 is a covalent inhibitor of Bruton's tyrosine kinase (BTK) designed for the treatment of medical conditions including cardiovascular diseases,</p>Fórmula:C23H32N4O5Forma y color:SolidPeso molecular:444.532GBD-9
CAS:<p>GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN).</p>Fórmula:C44H47N9O6Pureza:98%Forma y color:SolidPeso molecular:797.9TLT8
<p>TLT8 is a ByeTAC protein degrader that targets BTK. It induces BTK degradation by non-covalently binding to Rpn-13 and BTK. TLT8 is applicable in research on chronic lymphocytic leukemia.</p>Forma y color:Odour SolidNRX-0492
CAS:<p>NRX-0492: orally active BTK degrader, induces ubiquitylation/proteasomal breakdown, potent with DC50 ≤0.2 nM, DC90 ≤0.5 nM, disrupts BCR signaling.</p>Fórmula:C43H51N11O6Forma y color:SolidPeso molecular:817.94PTD10
CAS:<p>PTD10, a highly potent PROTAC BTK degrader, exhibits a DC50 of 0.5 nM and a KD of 2.28 nM.</p>Fórmula:C49H51N11O8Pureza:98%Forma y color:SolidPeso molecular:922PROTAC BTK Degrader-1
CAS:<p>Potent, selective oral PROTAC BTK Degrader-1; IC50: 34.51 nM (WT), 64.56 nM (BTK-481S); reduces BTK protein, inhibits tumors.</p>Fórmula:C43H43N9O4Forma y color:SolidPeso molecular:749.86BTK ligand-14
<p>BTKligand-14 is a PROTAC-targeting ligand for BTK, suitable for the synthesis of FDU73.</p>Forma y color:Odour SolidBRK inhibitor P21d hydrochloride
CAS:<p>BRK inhibitor P21d HCl targets breast tumor kinase with 30 nM IC50, suppresses p-SAM68 at 52 nM, useful for in vivo breast cancer research.</p>Fórmula:C23H23ClFN7O2Forma y color:SolidPeso molecular:483.93Tyrosinase-IN-16
CAS:<p>Tyrosinase-IN-16 inhibited tyrosinase.</p>Fórmula:C8H6BrN3SPureza:99.57%Forma y color:SolidPeso molecular:256.12
