Trombina
Los inhibidores de trombina son compuestos que bloquean la trombina, una enzima involucrada en el proceso de coagulación de la sangre que también desempeña un papel en la promoción de la angiogénesis. La trombina puede estimular la formación de nuevos vasos sanguíneos en los tumores, favoreciendo su crecimiento y metástasis. Al inhibir la trombina, estos compuestos pueden reducir la angiogénesis y la progresión tumoral. Los inhibidores de trombina son importantes tanto en la investigación del cáncer como en el estudio de enfermedades vasculares. En CymitQuimica, ofrecemos una selección de inhibidores de trombina de alta calidad para apoyar su investigación en hemostasia, oncología y angiogénesis.
Se han encontrado 62 productos para "Trombina".
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Enoxaparin sodium
CAS:Enoxaparin, a low-weight heparin approved by FDA for STEMI, enhances antithrombin and prevents clotting by inhibiting factors XIa, IXa, Xa, IIa.Fórmula:C42H59N3Na4O35S2Pureza:98%Forma y color:White SolidPeso molecular:1322AEBSF hydrochloride
CAS:AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.Fórmula:C8H11ClFNO2SPureza:98% - 99.81%Forma y color:SolidPeso molecular:239.69H-D-Phe-Pip-Arg-pNA dihydrochloride
CAS:H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238) is a sensitive and accurate thrombin detection substrate for measuring antithrombin-heparin cofactor (AT-III).Fórmula:C27H38Cl2N8O5Pureza:99.47%Forma y color:SolidPeso molecular:625.547Bivalirudin
CAS:Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clottingFórmula:C98H138N24O33Pureza:98.80% - >99.99%Forma y color:White SolidPeso molecular:2180.29Argatroban
CAS:Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.Fórmula:C23H36N6O5SPureza:99.77% - >99.99%Forma y color:White SolidPeso molecular:508.63Ichorcumab
CAS:Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.Pureza:95%Forma y color:LiquidPeso molecular:~148 kDaIdarucizumab
CAS:Idarucizumab, a humanized monoclonal antibody fragment, serves as the first reversal agent for direct oral anticoagulants (DOACs).Forma y color:LiquidOM-189
CAS:OM-189 is a selective inhibitor of synthetic thrombin.Fórmula:C24H36N6O3SPureza:98%Forma y color:SolidPeso molecular:488.65YD-3
CAS:YD-3 is a PAR4 antagonist that significantly inhibits thrombin-induced platelet aggregation in rabbits (IC(50)=28.3 microM). In addition, YD-3 suppresses thrombin-induced proliferation of vascular smooth muscle cells (VSMCs) and reduces neointimal thickening after balloon injury. Through Ras- and ERK1/2-mediated signaling pathways, YD-3 impedes thrombin-driven VSMC proliferation. When analyzed with Western blot, YD-3 primarily inhibits thrombin-induced expression of vascular endothelial growth factor receptor 2 (Flk-1) without affecting extracellular signal-regulated kinase 1/2 phosphorylation. YD-3 could potentially have value in elucidating the pathophysiology of thrombin-induced angiogenesis.Fórmula:C23H20N2O2Forma y color:SolidPeso molecular:356.42Thrombin inhibitor 13
CAS:Thrombin inhibitor 13 (Compound 13a) acts as a covalent reversible inhibitor of thrombin (thrombin, FIIa) with an IC50 of 0.7 nM. This compound prolongs activated partial thromboplastin time (aPTT) and prothrombin time (PT), demonstrating both antithrombotic and anticoagulant properties.Fórmula:C16H17ClN6OSForma y color:SolidPeso molecular:376.864Atopaxar Hydrobromide
CAS:Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.Fórmula:C29H39BrFN3O5Pureza:98%Forma y color:SolidPeso molecular:608.539Flovagatran
CAS:Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.Fórmula:C27H36BN3O7Pureza:99.56%Forma y color:SolidPeso molecular:525.4Efegatran sulfate
CAS:Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.Fórmula:C21H34N6O7SPureza:97.51% - 99.49%Forma y color:SolidPeso molecular:514.6TPO agonist 1
CAS:TPO agonist 1, Thrombopoietin (TPO) mimetic, promotes platelet/megakaryocyte production, for thrombocytopenia research.Fórmula:C25H22N8O2Pureza:98%Forma y color:Red SolidPeso molecular:466.4946Atopaxar
CAS:Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.Fórmula:C29H38FN3O5Pureza:97.07% - 98.07%Forma y color:SolidPeso molecular:527.6275Melagatran
CAS:Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin.Cost-effective and quality-assured.Fórmula:C22H31N5O4Pureza:99.79% - >99.99%Forma y color:White SolidPeso molecular:429.5126Thrombin inhibitor 1
CAS:Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).Fórmula:C22H20Cl2F2N4O3Pureza:98%Forma y color:SolidPeso molecular:497.32SCH79797 dihydrochloride
CAS:SCH79797 dihydrochloride is a PAR1 antagonist with IC50 70 nM, Ki 35 nM, antiproliferative, and pro-apoptotic properties.Fórmula:C23H27Cl2N5Pureza:99.5%Forma y color:White SolidPeso molecular:444.4Antiplatelet agent 3
CAS:Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.Fórmula:C38H32N2O5Forma y color:SolidPeso molecular:596.671SAR107375
CAS:SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].Fórmula:C24H30ClN5O5S2Forma y color:SolidPeso molecular:568.11
