PERK
Los inhibidores de PERK (quinasa del retículo endoplásmico similar a la proteína quinasa R (PKR)) se dirigen a la vía PERK, que está involucrada en la respuesta celular al estrés del retículo endoplásmico (ER) y en la regulación de la apoptosis. PERK juega un papel crucial en la respuesta a proteínas mal plegadas (UPR) al detener la traducción de proteínas y promover la supervivencia celular bajo condiciones de estrés. Sin embargo, la activación prolongada de PERK puede conducir a la apoptosis. Inhibir PERK puede modular estas respuestas al estrés, lo que convierte a estos inhibidores en herramientas valiosas en la investigación de enfermedades neurodegenerativas, cáncer y trastornos metabólicos. En CymitQuimica, ofrecemos una gama de inhibidores de PERK de alta calidad para apoyar su investigación en apoptosis, estrés del RE y homeostasis celular.
Se han encontrado 25 productos de "PERK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Claturafenib
CAS:<p>Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.</p>Fórmula:C18H15Cl2F2N5O3SPureza:98.68% - 99.85%Forma y color:SolidPeso molecular:490.31PERK-IN-6
CAS:<p>PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).</p>Fórmula:C23H22N6OPureza:99.62% - 99.92%Forma y color:SolidPeso molecular:398.46PERK-IN-4
CAS:<p>PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.</p>Fórmula:C24H19F4N5OPureza:98.07% - 98.95%Forma y color:SolidPeso molecular:469.43EIF2α activator 2
CAS:<p>EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.</p>Fórmula:C21H20F6N2O2Pureza:98.86%Forma y color:SolidPeso molecular:446.39IACS-13909
CAS:<p>IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.</p>Fórmula:C17H18Cl2N6Pureza:98.8%Forma y color:SolidPeso molecular:377.27GSK2606414
CAS:<p>GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.</p>Fórmula:C24H20F3N5OPureza:98% - >99.99%Forma y color:SolidPeso molecular:451.44Bufotalin
CAS:<p>1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.</p>Fórmula:C26H36O6Pureza:99.45% - 99.91%Forma y color:White To Off-White SolidPeso molecular:444.564E1rcat
CAS:<p>4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.</p>Fórmula:C28H18N2O6Pureza:99.47%Forma y color:SolidPeso molecular:478.45ONO-8130
CAS:<p>ONO-8130 is an orally available antagonist of EP1 receptor.</p>Fórmula:C25H28N2O5S2Pureza:97.82%Forma y color:SolidPeso molecular:500.63GSK621
CAS:<p>GSK621 is a specific and potent AMPK activator.</p>Fórmula:C26H20ClN3O5Pureza:97.02% - 97.05%Forma y color:SolidPeso molecular:489.912BAct
CAS:<p>2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response</p>Fórmula:C19H16ClF3N4O3Pureza:97.97% - 99.04%Forma y color:SolidPeso molecular:440.8Takeda-6d
CAS:<p>Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.</p>Fórmula:C27H19ClFN5O3SPureza:98.27%Forma y color:SolidPeso molecular:547.99ISRIB (trans-isomer)
CAS:<p>ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.</p>Fórmula:C22H24Cl2N2O4Pureza:97.86% - 99.27%Forma y color:SolidPeso molecular:451.34SBI-0640756
CAS:<p>SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.</p>Fórmula:C23H14ClFN2O2Pureza:99.75%Forma y color:SolidPeso molecular:404.82GSK2656157
CAS:<p>GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.</p>Fórmula:C23H21FN6OPureza:98.59% - >99.99%Forma y color:SolidPeso molecular:416.45DNL343
CAS:<p>DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.</p>Fórmula:C20H19ClF3N3O4Pureza:99.96%Forma y color:SolidPeso molecular:457.83AMG PERK 44
CAS:<p>AMG PERK 44 is a PERK inhibitor that induces autophagy.AMG PERK 44 inhibits GCN2 and B-Raf and can be used in cancer research.</p>Fórmula:C34H29ClN4O2Pureza:98.8% - 99.81%Forma y color:SolidPeso molecular:561.07eIF4A3-IN-1
CAS:<p>eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.</p>Fórmula:C29H23BrClN5O2Pureza:99.49% - 99.89%Forma y color:SolidPeso molecular:588.88PF-07284892
CAS:<p>PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.</p>Fórmula:C21H22ClN7SPureza:97.77%Forma y color:SolidPeso molecular:439.96GCN2-IN-6
CAS:<p>GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).</p>Fórmula:C19H12Cl2F2N4O3SPureza:95.04% - 98%Forma y color:SolidPeso molecular:485.29
