PERK
Los inhibidores de PERK (quinasa del retículo endoplásmico similar a la proteína quinasa R (PKR)) se dirigen a la vía PERK, que está involucrada en la respuesta celular al estrés del retículo endoplásmico (ER) y en la regulación de la apoptosis. PERK juega un papel crucial en la respuesta a proteínas mal plegadas (UPR) al detener la traducción de proteínas y promover la supervivencia celular bajo condiciones de estrés. Sin embargo, la activación prolongada de PERK puede conducir a la apoptosis. Inhibir PERK puede modular estas respuestas al estrés, lo que convierte a estos inhibidores en herramientas valiosas en la investigación de enfermedades neurodegenerativas, cáncer y trastornos metabólicos. En CymitQuimica, ofrecemos una gama de inhibidores de PERK de alta calidad para apoyar su investigación en apoptosis, estrés del RE y homeostasis celular.
Se han encontrado 26 productos para "PERK".
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Daraxonrasib
CAS:Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Fórmula:C44H58N8O5SPureza:98.24% - 99.98%Forma y color:White SolidPeso molecular:811.05Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Fórmula:C18H15Cl2F2N5O3SPureza:98.68% - 99.85%Forma y color:SolidPeso molecular:490.31Ref: TM-T201081
10mgA consultar25mgA consultar50mgA consultar1mg66,00€5mg145,00€1mL*10mM (DMSO)157,00€eIF4E-IN-3
CAS:eIF4E-IN-3 is an eIF4E inhibitor that blocks cap-dependent translation and is used in cancer-related mechanism studies.Fórmula:C34H30ClF3N6O4SForma y color:SolidPeso molecular:711.16PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Fórmula:C23H22N6OPureza:99.62% - 99.92%Forma y color:SolidPeso molecular:398.46PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Fórmula:C24H19F4N5OPureza:99.44% - 99.49%Forma y color:SolidPeso molecular:469.43ML-291
CAS:ML-291 is a potent UPR inducer; activates PERK/eIF2α/CHOP apoptotic arm; cancer cell death research tool.Fórmula:C16H16ClN3O6SPureza:99.79%Forma y color:White SolidPeso molecular:413.83EIF2α activator 2
CAS:EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Fórmula:C21H20F6N2O2Pureza:98.86%Forma y color:White SolidPeso molecular:446.39Ref: TM-T62637
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg177,00€25mg333,00€50mg495,00€100mg710,00€200mg973,00€ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Fórmula:C22H24Cl2N2O4Pureza:97.86% - 99.27%Forma y color:SolidPeso molecular:451.34GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Fórmula:C24H20F3N5OPureza:98% - >99.99%Forma y color:White SolidPeso molecular:451.44IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Forma y color:SolidPeso molecular:377.272BAct
CAS:2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFórmula:C19H16ClF3N4O3Pureza:97.97% - 99.04%Forma y color:SolidPeso molecular:440.8Bufotalin
CAS:1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.Fórmula:C26H36O6Pureza:99.45% - 99.91%Forma y color:SolidPeso molecular:444.56Ref: TM-T5A2461
1mg46,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg137,00€25mg224,00€50mg331,00€100mg489,00€500mg1.044,00€ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Fórmula:C25H28N2O5S2Pureza:97.82% - 98.94%Forma y color:White SolidPeso molecular:500.63Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Fórmula:C27H19ClFN5O3SPureza:98.27%Forma y color:Yellow SolidPeso molecular:547.99Ref: TM-T22436
1mg92,00€2mg128,00€5mg178,00€1mL*10mM (DMSO)243,00€10mg268,00€25mg439,00€50mg610,00€100mg820,00€200mg1.099,00€GSK621
CAS:GSK621 is a specific and potent AMPK activator.Fórmula:C26H20ClN3O5Pureza:97.02% - 97.05%Forma y color:SolidPeso molecular:489.91GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Fórmula:C23H21FN6OPureza:98.59% - >99.99%Forma y color:SolidPeso molecular:416.45Ref: TM-T2654
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg135,00€50mg245,00€100mg442,00€200mg598,00€PERK/eIF2α activator 1
CAS:Compound V8 (PERK/eIF2α activator 1), a flavonoid, exhibits anti-tumor properties by inducing apoptosis and activating the PERK-eIF2α-ATF4 pathway. It effectively inhibits the proliferation of HepG2 cells, with an IC 50 value of 23 μM [1].Fórmula:C24H29NO7Forma y color:SolidPeso molecular:443.49DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Fórmula:C20H19ClF3N3O4Pureza:99.96%Forma y color:SolidPeso molecular:457.83eIF4A3-IN-1
CAS:eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.Fórmula:C29H23BrClN5O2Pureza:99.49% - 99.89%Forma y color:SolidPeso molecular:588.88Ref: TM-T11170
1mg132,00€2mg187,00€5mg319,00€1mL*10mM (DMSO)413,00€10mg528,00€25mg1.054,00€50mg1.414,00€100mg1.908,00€200mg2.575,00€GCN2-IN-6
CAS:GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).Fórmula:C19H12Cl2F2N4O3SPureza:95.04% - 98.72%Forma y color:Yellow SolidPeso molecular:485.29
