Caspasa
Los inhibidores de caspasas son compuestos que bloquean la actividad de las caspasas, una familia de proteasas que son ejecutores centrales de la apoptosis. Las caspasas escinden sustratos específicos dentro de la célula para desencadenar el proceso apoptótico, lo que conduce a la muerte celular programada. Los inhibidores de caspasas se utilizan para estudiar los mecanismos de la apoptosis, así como para prevenir la muerte celular no deseada en varios modelos de investigación. Estos inhibidores también se exploran en contextos terapéuticos para proteger las células de la apoptosis en enfermedades como la neurodegeneración. En CymitQuimica, ofrecemos una amplia gama de inhibidores de caspasas de alta calidad para apoyar su investigación en apoptosis, muerte celular y campos relacionados.
Se han encontrado 125 productos de "Caspasa"
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Crustecdysone
CAS:<p>Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.</p>Fórmula:C27H44O7Pureza:99.06% - 99.67%Forma y color:Canary Yellow Fine PowderPeso molecular:480.63Diclofenac diethylamine
CAS:<p>Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).</p>Fórmula:C18H22Cl2N2O2Pureza:99.81% - 99.87%Forma y color:SolidPeso molecular:369.29Lacidipine
CAS:<p>Lacidipine (SN-305) is a slow-acting, long-duration lipophilic dihydropyridine calcium blocker that prevents reflex tachycardia and lowers blood pressure.</p>Fórmula:C26H33NO6Pureza:99.98%Forma y color:White-To-Off-White Crystalline SolidPeso molecular:455.54Oxidopamine hydrobromide
CAS:<p>Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.</p>Fórmula:C8H12BrNO3Pureza:98.22% - 99.88%Forma y color:Beige To Brown Fine Crystalline PowderPeso molecular:250.09Terfenadine
CAS:<p>Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.</p>Fórmula:C32H41NO2Pureza:98.76% - 99.75%Forma y color:SolidPeso molecular:471.67Ac-YVAD-CMK
CAS:<p>Ac-YVAD-CMK: Irreversible Caspase-1 inhibitor; halts pyroptosis, IL-1β/IL-18; neuroprotective and anti-inflammatory.</p>Fórmula:C24H33ClN4O8Pureza:97.08% - 99.909%Forma y color:SolidPeso molecular:540.99Q-VD-OPH
CAS:<p>Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12.</p>Fórmula:C26H25F2N3O6Pureza:97.8% - 98.95%Forma y color:SolidPeso molecular:513.5ML-9
CAS:<p>ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.</p>Fórmula:C15H18Cl2N2O2SPureza:99.69%Forma y color:Crystalline SolidPeso molecular:361.29Thiabendazole
CAS:<p>Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.</p>Fórmula:C10H7N3SPureza:99.14%Forma y color:Light Yellow PowderPeso molecular:201.25Diclofenac sodium
CAS:<p>Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.</p>Fórmula:C14H10Cl2NNaO2Pureza:98.21% - 99.73%Forma y color:White Or Off-White PowderPeso molecular:318.13Diclofenac
CAS:<p>Diclofenac: a nonsteroidal compound inhibiting COX-1 and COX-2, reducing pro-inflammatory prostaglandins.</p>Fórmula:C14H11Cl2NO2Pureza:99.69% - 99.97%Forma y color:Crystals From Ether-Petroleum Ether SolidPeso molecular:296.15Dehydrocorydaline chloride
CAS:<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Fórmula:C22H24ClNO4Pureza:99.53%Forma y color:SolidPeso molecular:401.88Oxidopamine hydrochloride
CAS:<p>Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.</p>Fórmula:C8H12ClNO3Pureza:98.34% - 99.85%Forma y color:Physical Description Beige Solid (Ntp 1992)Peso molecular:205.64Ac-FLTD-CMK
CAS:<p>Ac-FLTD-CMK, an abscisicin D derivative, selectively inhibits inflammatory caspases-1, -4, and -11 (IC50: 46.7 nM, 1.49 μM, 329 nM) but not caspase-3.</p>Fórmula:C26H37ClN4O8Pureza:95.17%Forma y color:SolidPeso molecular:569.05Fenbufen
CAS:<p>Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.</p>Fórmula:C16H14O3Pureza:98.35% - 98.46%Forma y color:White SolidPeso molecular:254.28Aspirin
CAS:<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Fórmula:C9H8O4Pureza:99.78% - 99.91%Forma y color:White Solid CrystallinePeso molecular:180.16Ac-Trp-Glu-His-Asp-Aldehyde
CAS:<p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>Fórmula:C28H33N7O9Forma y color:SolidPeso molecular:611.6Ac-VDVAD-CHO TFA
<p>Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.</p>Forma y color:Odour SolidCaspase-3 activator 2
<p>Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM,</p>Pureza:98%Forma y color:Odour SolidSanggenon G
CAS:<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Fórmula:C40H38O11Forma y color:SolidPeso molecular:694.72TD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Fórmula:C55H70N8O9Forma y color:SolidPeso molecular:987.19Ac-IEPD-AFC
CAS:<p>Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.</p>Fórmula:C32H38F3N5O11Pureza:99.16%Forma y color:SolidPeso molecular:725.67δ-secretase inhibitor 11
CAS:<p>δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.</p>Fórmula:C10H12N4O2Pureza:99.84%Forma y color:SolidPeso molecular:220.23IRF1-IN-2
CAS:<p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>Fórmula:C18H20N2O4SPureza:99.85%Forma y color:SolidPeso molecular:360.43Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Forma y color:Odour SolidSarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Fórmula:C38H44O12Pureza:98%Forma y color:SolidPeso molecular:692.75Apoptosis Compound Library
<p>A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;</p>Forma y color:Odour SolidZ-VDVA-(DL-Asp)-FMK
CAS:<p>Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.</p>Fórmula:C32H46FN5O11Forma y color:SolidPeso molecular:695.742Boc-Asp(OBzl)-CMK
CAS:<p>Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].</p>Fórmula:C17H22ClNO5Forma y color:SolidPeso molecular:355.81Ac-LEVD-CHO
CAS:<p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>Fórmula:C22H36N4O9Forma y color:SolidPeso molecular:500.54IRF1-IN-1
CAS:<p>IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.</p>Fórmula:C22H24N4O4SPureza:99.88%Forma y color:SolidPeso molecular:440.52AKN-028
CAS:<p>AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.</p>Fórmula:C17H14N6Pureza:99.88%Forma y color:SolidPeso molecular:302.33Z-WEHD-FMK
CAS:<p>Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).</p>Fórmula:C37H42FN7O10Pureza:98%Forma y color:SolidPeso molecular:763.78Pralnacasan
CAS:<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Fórmula:C26H29N5O7Pureza:98%Forma y color:SolidPeso molecular:523.54PQ401
CAS:<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Fórmula:C18H16ClN3O2Pureza:99.77%Forma y color:SolidPeso molecular:341.79BOC-D-FMK
CAS:<p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>Fórmula:C11H18FNO5Pureza:97.02%Forma y color:SolidPeso molecular:263.26Reproxalap
CAS:<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Fórmula:C12H13ClN2OPureza:99.4% - 99.97%Forma y color:SolidPeso molecular:236.7Ac-LEHD-AMC
CAS:<p>Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.</p>Fórmula:C33H41N7O11Forma y color:SolidPeso molecular:711.729TNF-α-IN-11
<p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>Fórmula:C24H26N2O5Forma y color:SolidPeso molecular:422.47(Iso)-Z-VAD(OMe)-FMK
CAS:<p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>Fórmula:C22H30FN3O7Pureza:97.10%Forma y color:SoildPeso molecular:467.49J22352
CAS:<p>J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in</p>Fórmula:C24H21N3O4Forma y color:SolidPeso molecular:415.44Almorexant hydrochloride
CAS:<p>Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.</p>Fórmula:C29H32ClF3N2O3Pureza:99.85%Forma y color:SolidPeso molecular:549.02MX1013
CAS:<p>MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.</p>Fórmula:C18H23FN2O6Forma y color:SolidPeso molecular:382.39Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Fórmula:C51H82O21Pureza:99.51% - 99.63%Forma y color:SolidPeso molecular:1031.18Asperosaponin VI
CAS:<p>Asperosaponin VI, from Dipsacus asper rhizome, treats back pain, hematoma, and fractures.</p>Fórmula:C47H76O18Pureza:97.15% - 99.79%Forma y color:SolidPeso molecular:929.1KEA1-97
CAS:<p>Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M).</p>Fórmula:C15H9Cl2FN4Pureza:97.07%Forma y color:SolidPeso molecular:335.16CASP3 Activator 1541
CAS:<p>CASP3 Activator 1541 is an activator of the proenzyme forms of caspase-3, and induces cell death.</p>Fórmula:C24H17N3O4Pureza:98.84%Forma y color:SolidPeso molecular:411.41Taurodeoxycholic acid sodium hydrate
CAS:<p>Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.</p>Fórmula:C26H46NNaO7SPureza:99.95%Forma y color:SolidPeso molecular:539.70Chelidonic acid
CAS:<p>Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.</p>Fórmula:C7H4O6Pureza:99.03%Forma y color:SolidPeso molecular:184.1Ac-DEVD-AMC
CAS:<p>Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .</p>Fórmula:C30H37N5O13Pureza:98.20%Forma y color:White PowderPeso molecular:675.64
