Caspasa
Los inhibidores de caspasas son compuestos que bloquean la actividad de las caspasas, una familia de proteasas que son ejecutores centrales de la apoptosis. Las caspasas escinden sustratos específicos dentro de la célula para desencadenar el proceso apoptótico, lo que conduce a la muerte celular programada. Los inhibidores de caspasas se utilizan para estudiar los mecanismos de la apoptosis, así como para prevenir la muerte celular no deseada en varios modelos de investigación. Estos inhibidores también se exploran en contextos terapéuticos para proteger las células de la apoptosis en enfermedades como la neurodegeneración. En CymitQuimica, ofrecemos una amplia gama de inhibidores de caspasas de alta calidad para apoyar su investigación en apoptosis, muerte celular y campos relacionados.
Se han encontrado 125 productos de "Caspasa"
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Aspirin
CAS:<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Fórmula:C9H8O4Pureza:99.78% - 99.91%Forma y color:White Solid CrystallinePeso molecular:180.16Q-VD-OPH
CAS:<p>Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12.</p>Fórmula:C26H25F2N3O6Pureza:97.8% - 98.95%Forma y color:SolidPeso molecular:513.5Thiabendazole
CAS:<p>Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.</p>Fórmula:C10H7N3SPureza:99.14%Forma y color:Light Yellow PowderPeso molecular:201.25Fenbufen
CAS:<p>Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.</p>Fórmula:C16H14O3Pureza:98.35% - 98.46%Forma y color:White SolidPeso molecular:254.28Diclofenac sodium
CAS:<p>Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.</p>Fórmula:C14H10Cl2NNaO2Pureza:98.21% - 99.73%Forma y color:White Or Off-White PowderPeso molecular:318.13Ac-FLTD-CMK
CAS:<p>Ac-FLTD-CMK, an abscisicin D derivative, selectively inhibits inflammatory caspases-1, -4, and -11 (IC50: 46.7 nM, 1.49 μM, 329 nM) but not caspase-3.</p>Fórmula:C26H37ClN4O8Pureza:95.17%Forma y color:SolidPeso molecular:569.05Dehydrocorydaline chloride
CAS:<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Fórmula:C22H24ClNO4Pureza:99.53%Forma y color:SolidPeso molecular:401.88Ac-YVAD-CMK
CAS:<p>Ac-YVAD-CMK: Irreversible Caspase-1 inhibitor; halts pyroptosis, IL-1β/IL-18; neuroprotective and anti-inflammatory.</p>Fórmula:C24H33ClN4O8Pureza:97.08% - 99.909%Forma y color:SolidPeso molecular:540.99Lacidipine
CAS:<p>Lacidipine (SN-305) is a slow-acting, long-duration lipophilic dihydropyridine calcium blocker that prevents reflex tachycardia and lowers blood pressure.</p>Fórmula:C26H33NO6Pureza:99.98%Forma y color:White-To-Off-White Crystalline SolidPeso molecular:455.54Diclofenac diethylamine
CAS:<p>Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).</p>Fórmula:C18H22Cl2N2O2Pureza:99.81% - 99.87%Forma y color:SolidPeso molecular:369.29Diclofenac
CAS:<p>Diclofenac: a nonsteroidal compound inhibiting COX-1 and COX-2, reducing pro-inflammatory prostaglandins.</p>Fórmula:C14H11Cl2NO2Pureza:99.69% - 99.97%Forma y color:Crystals From Ether-Petroleum Ether SolidPeso molecular:296.15Terfenadine
CAS:<p>Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.</p>Fórmula:C32H41NO2Pureza:98.76% - 99.75%Forma y color:SolidPeso molecular:471.67ML-9
CAS:<p>ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.</p>Fórmula:C15H18Cl2N2O2SPureza:99.69%Forma y color:Crystalline SolidPeso molecular:361.29Oxidopamine hydrochloride
CAS:<p>Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.</p>Fórmula:C8H12ClNO3Pureza:98.34% - 99.85%Forma y color:Physical Description Beige Solid (Ntp 1992)Peso molecular:205.64Oxidopamine hydrobromide
CAS:<p>Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.</p>Fórmula:C8H12BrNO3Pureza:98.22% - 99.88%Forma y color:Beige To Brown Fine Crystalline PowderPeso molecular:250.09Crustecdysone
CAS:<p>Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.</p>Fórmula:C27H44O7Pureza:99.06% - 99.67%Forma y color:Canary Yellow Fine PowderPeso molecular:480.63Caspase-3 activator 2
<p>Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM,</p>Pureza:98%Forma y color:Odour SolidZ-VDVA-(DL-Asp)-FMK
CAS:<p>Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.</p>Fórmula:C32H46FN5O11Forma y color:SolidPeso molecular:695.742PQ401
CAS:<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Fórmula:C18H16ClN3O2Pureza:99.77%Forma y color:SolidPeso molecular:341.79Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Forma y color:Odour SolidBOC-D-FMK
CAS:<p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>Fórmula:C11H18FNO5Pureza:97.02%Forma y color:SolidPeso molecular:263.26(Iso)-Z-VAD(OMe)-FMK
CAS:<p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>Fórmula:C22H30FN3O7Pureza:97.10%Forma y color:SoildPeso molecular:467.49Apoptosis Compound Library
<p>A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;</p>Forma y color:Odour SolidSanggenon G
CAS:<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Fórmula:C40H38O11Forma y color:SolidPeso molecular:694.72Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Fórmula:C38H44O12Pureza:98%Forma y color:SolidPeso molecular:692.75TNF-α-IN-11
<p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>Fórmula:C24H26N2O5Forma y color:SolidPeso molecular:422.47Ac-VDVAD-CHO TFA
<p>Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.</p>Forma y color:Odour SolidAc-Trp-Glu-His-Asp-Aldehyde
CAS:<p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>Fórmula:C28H33N7O9Forma y color:SolidPeso molecular:611.6IRF1-IN-2
CAS:<p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>Fórmula:C18H20N2O4SPureza:99.85%Forma y color:SolidPeso molecular:360.43Ac-LEHD-AMC
CAS:<p>Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.</p>Fórmula:C33H41N7O11Forma y color:SolidPeso molecular:711.729Reproxalap
CAS:<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Fórmula:C12H13ClN2OPureza:99.4% - 99.97%Forma y color:SolidPeso molecular:236.7Ac-LEVD-CHO
CAS:<p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>Fórmula:C22H36N4O9Forma y color:SolidPeso molecular:500.54Boc-Asp(OBzl)-CMK
CAS:<p>Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].</p>Fórmula:C17H22ClNO5Forma y color:SolidPeso molecular:355.81δ-secretase inhibitor 11
CAS:<p>δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.</p>Fórmula:C10H12N4O2Pureza:99.84%Forma y color:SolidPeso molecular:220.23Pralnacasan
CAS:<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Fórmula:C26H29N5O7Pureza:98%Forma y color:SolidPeso molecular:523.54Z-WEHD-FMK
CAS:<p>Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).</p>Fórmula:C37H42FN7O10Pureza:98%Forma y color:SolidPeso molecular:763.78Ac-IEPD-AFC
CAS:<p>Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.</p>Fórmula:C32H38F3N5O11Pureza:99.16%Forma y color:SolidPeso molecular:725.67IRF1-IN-1
CAS:<p>IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.</p>Fórmula:C22H24N4O4SPureza:99.88%Forma y color:SolidPeso molecular:440.52AKN-028
CAS:<p>AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.</p>Fórmula:C17H14N6Pureza:99.88%Forma y color:SolidPeso molecular:302.33TD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Fórmula:C55H70N8O9Forma y color:SolidPeso molecular:987.19MX1013
CAS:<p>MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.</p>Fórmula:C18H23FN2O6Forma y color:SolidPeso molecular:382.39Almorexant hydrochloride
CAS:<p>Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.</p>Fórmula:C29H32ClF3N2O3Pureza:99.85%Forma y color:SolidPeso molecular:549.02J22352
CAS:<p>J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in</p>Fórmula:C24H21N3O4Forma y color:SolidPeso molecular:415.44EF24
CAS:<p>EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.</p>Fórmula:C19H15F2NOPureza:99.71%Forma y color:SolidPeso molecular:311.33PAC-1
CAS:<p>PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer and Thoracic Cancers.</p>Fórmula:C23H28N4O2Pureza:96.78% - 99.77%Forma y color:SolidPeso molecular:392.49Ivachtin
CAS:<p>Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining</p>Fórmula:C20H21N3O7SPureza:99.74%Forma y color:SolidPeso molecular:447.46Penicillic acid
CAS:<p>Penicillic acid, a mycotoxin from Aspergillus/Penicillium, blocks Fas ligand apoptosis and is cytotoxic to rat lung macrophages.</p>Fórmula:C8H10O4Pureza:98%Forma y color:Needles From Petroleum Ether Slight Yellow PowderPeso molecular:170.16Guggulsterone
CAS:<p>Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.</p>Fórmula:C21H28O2Pureza:99.4% - 99.8%Forma y color:Light Yellow PowderPeso molecular:312.455,7,4'-Trimethoxyflavone
CAS:<p>5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.</p>Fórmula:C18H16O5Pureza:97.53%Forma y color:SolidPeso molecular:312.32Chelidonic acid
CAS:<p>Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.</p>Fórmula:C7H4O6Pureza:99.03%Forma y color:SolidPeso molecular:184.1Almorexant
CAS:<p>Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.</p>Fórmula:C29H31F3N2O3Pureza:97.75% - 98.02%Forma y color:SolidPeso molecular:512.56Asperosaponin VI
CAS:<p>Asperosaponin VI, from Dipsacus asper rhizome, treats back pain, hematoma, and fractures.</p>Fórmula:C47H76O18Pureza:97.15% - 99.79%Forma y color:SolidPeso molecular:929.1Z-IETD-FMK
CAS:<p>Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective caspase 8 inhibitor, which has cell permeable.</p>Fórmula:C30H43FN4O11Pureza:95% - 99.81%Forma y color:SolidPeso molecular:654.68Ginsenoside Rh2
CAS:<p>Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.</p>Fórmula:C36H62O8Pureza:99.20% - 99.76%Forma y color:White PowderPeso molecular:622.872-HBA
CAS:<p>2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.</p>Fórmula:C17H14O3Pureza:99.76%Forma y color:SolidPeso molecular:266.29Ac-DEVD-AMC
CAS:<p>Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .</p>Fórmula:C30H37N5O13Pureza:98.20%Forma y color:White PowderPeso molecular:675.64KEA1-97
CAS:<p>Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M).</p>Fórmula:C15H9Cl2FN4Pureza:97.07%Forma y color:SolidPeso molecular:335.16Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Fórmula:C51H82O21Pureza:99.51% - 99.63%Forma y color:SolidPeso molecular:1031.18Z-VAD(OMe)-FMK
CAS:<p>View and buy Z-VAD(OMe)-FMK from TargetMol.Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.Cited in 10 publications.</p>Fórmula:C22H30FN3O7Pureza:95.92% - 99.71%Forma y color:SolidPeso molecular:467.49Ac-DEVD-CHO acetate
<p>Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.</p>Fórmula:C22H34N4O13Pureza:98.54%Forma y color:SolidPeso molecular:562.52PHYTOSPHINGOSINE
CAS:<p>Phytosphingosine: anticancer phospholipid; triggers apoptosis in cancer cells via caspase 8 activation and Bax translocation.</p>Fórmula:C18H39NO3Pureza:99.81%Forma y color:SolidPeso molecular:317.51TC11
CAS:<p>TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis</p>Fórmula:C20H22N2O2Pureza:97.86%Forma y color:SolidPeso molecular:322.4Belnacasan
CAS:<p>Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.</p>Fórmula:C24H33ClN4O6Pureza:96.53% - 99.5%Forma y color:SolidPeso molecular:508.99Sesamolin
CAS:<p>Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.</p>Fórmula:C20H18O7Pureza:98.77% - 99.04%Forma y color:SolidPeso molecular:370.35Wedelolactone
CAS:<p>Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.</p>Fórmula:C16H10O7Pureza:98.07% - 99.87%Forma y color:SolidPeso molecular:314.25PI-1840
CAS:<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Fórmula:C22H26N4O3Pureza:98.82%Forma y color:SolidPeso molecular:394.47Dehydrocorydaline
CAS:<p>1.</p>Fórmula:C22H24NO4Pureza:99.84%Forma y color:SolidPeso molecular:366.43Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14Ac-DEVD-pNA
CAS:<p>Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.</p>Fórmula:C26H34N6O13Pureza:>99.99%Forma y color:WhitePeso molecular:638.58Z-YVAD-FMK
CAS:<p>AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.</p>Fórmula:C31H39FN4O9Pureza:98.00%Forma y color:SolidPeso molecular:630.66Emricasan
CAS:<p>Emricasan (IDN-6556) is a pan-caspase inhibitor with irreversible properties.</p>Fórmula:C26H27F4N3O7Pureza:98.13% - 99%Forma y color:SolidPeso molecular:569.5Z-FA-FMK
CAS:<p>Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.</p>Fórmula:C21H23FN2O4Pureza:98.84% - 99.68%Forma y color:SolidPeso molecular:386.42Dihydrocapsaicin
CAS:<p>Dihydrocapsaicin, similar to capsaicin, is an irritant found in Capsicum, used in "pure" capsaicin products at about 10%, activates VR1, and is an antioxidant.</p>Fórmula:C18H29NO3Pureza:99.61% - ≥95%Forma y color:White CrystalPeso molecular:307.43Aristolactam I
CAS:<p>Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway.</p>Fórmula:C17H11NO4Pureza:98.98% - 99.63%Forma y color:SolidPeso molecular:293.27Ossirene
CAS:<p>Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.</p>Fórmula:C2H4Cl3O2Te·H4NPureza:≥98%Forma y color:SolidPeso molecular:312.05Tauroursodeoxycholate
CAS:<p>Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.</p>Fórmula:C26H45NO6SPureza:98.77% - 99.93%Forma y color:White SolidPeso molecular:499.7Senkyunolide I
CAS:<p>1. Senkyunolide I has neuroprotective effect, associated with its anti-oxidation and anti-apoptosis properties.</p>Fórmula:C12H16O4Pureza:99.73% - 99.88%Forma y color:SolidPeso molecular:224.25Diclofenac Potassium
CAS:<p>Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.</p>Fórmula:C14H10Cl2KNO2Pureza:99.51%Forma y color:White To Yellowish Crystalline PowderPeso molecular:334.24CASP3 Activator 1541
CAS:<p>CASP3 Activator 1541 is an activator of the proenzyme forms of caspase-3, and induces cell death.</p>Fórmula:C24H17N3O4Pureza:98.84%Forma y color:SolidPeso molecular:411.41L67
CAS:<p>L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).</p>Fórmula:C16H14Br2N4O4Pureza:98.34% - 99.56%Forma y color:SolidPeso molecular:486.11Phenoxodiol
CAS:<p>Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)</p>Fórmula:C15H12O3Pureza:98.07%Forma y color:SolidPeso molecular:240.25AVN-944
CAS:<p>AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.</p>Fórmula:C25H27N5O5Pureza:99.07% - ≥95%Forma y color:SolidPeso molecular:477.51Taurodeoxycholic acid sodium hydrate
CAS:<p>Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.</p>Fórmula:C26H46NNaO7SPureza:99.95%Forma y color:SolidPeso molecular:539.705,7-Dihydroxychromone
CAS:<p>1.</p>Fórmula:C9H6O4Pureza:99.76% - ≥95%Forma y color:SolidPeso molecular:178.14Boc-Asp(OMe)-fluoromethyl ketone
CAS:<p>Boc-Asp(OMe)-FMK is a broad-spectrum caspase inhibitor that blocks Fas-mediated processes without affecting IL-8 chemotaxis.</p>Fórmula:C11H18FNO5Pureza:≥98%Forma y color:SolidPeso molecular:263.26Tauroursodeoxycholate sodium
CAS:<p>Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.</p>Fórmula:C26H44NNaO6SPureza:97.90%Forma y color:SolidPeso molecular:521.69Z-VAD-FMK
CAS:<p>Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not</p>Fórmula:C21H28FN3O7Pureza:98.24% - 99.79%Forma y color:SolidPeso molecular:453.46(E/Z)-Necrosulfonamide
CAS:<p>(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.</p>Fórmula:C18H15N5O6S2Pureza:97.62% - 98%Forma y color:SolidPeso molecular:461.47Lobaplatin
CAS:<p>Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe.</p>Fórmula:C9H18N2O3PtPureza:98.00%Forma y color:SolidPeso molecular:397.33Z-DEVD-FMK
CAS:<p>Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7,</p>Fórmula:C30H41FN4O12Pureza:96.19% - 99.69%Forma y color:SolidPeso molecular:668.66Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Fórmula:C19H24O5Pureza:96.66%Forma y color:SolidPeso molecular:332.39Dehydrocorydaline nitrate
CAS:<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Fórmula:C22H24N2O7Pureza:99.79% - 99.92%Forma y color:SolidPeso molecular:428.44Dehydrotrametenolic acid
CAS:<p>Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in</p>Fórmula:C31H48O3Pureza:98%Forma y color:SolidPeso molecular:468.71Limonin glucoside
CAS:<p>Limonin glucoside: a citrus compound, blocks HIV/HTLV-1, triggers cancer cell death, kills Aedes larvae.</p>Fórmula:C32H42O14Forma y color:SolidPeso molecular:650.674Caspase-3-IN-1
CAS:<p>Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).</p>Fórmula:C26H25N3O6SForma y color:SolidPeso molecular:507.56Tigilanol tiglate
CAS:<p>Tigilanol tiglate (EBC-46) is a PKC/C1 domain activator. Tigilanol tiglate induces immunogenic cell death and tumour regression.</p>Fórmula:C30H42O10Pureza:98%Forma y color:SolidPeso molecular:562.65Anisperimus
CAS:<p>Anisperimus (LF 15-0195) is an immunosuppressant that prevents CNS autoimmunity by promoting the development of regulatory CD4 T cells expressing Foxp3.</p>Fórmula:C18H39N7O3Pureza:98.10%Forma y color:SolidPeso molecular:401.55AD-2646
CAS:<p>AD-2646 has antidepressant activity and inhibits 2-deoxy-D-glucose (2-DG)-induced gastric acid secretion.</p>Fórmula:C23H40N2O4Forma y color:SolidPeso molecular:408.57ZYZ-488
CAS:<p>ZYZ-488 is an Apoptosis protease activating factor-1 (Apaf-1) inhibitor, which suppresses the activation of procaspase-9 and procaspase-3.</p>Fórmula:C20H29N3O11Pureza:99.04%Forma y color:SolidPeso molecular:487.46Caspase-9 Inhibitor III
CAS:<p>Caspase-9 Inhibitor III (Ac-LEHD-cmk) blocks caspase-9, protects against ischemic heart damage.</p>Fórmula:C24H35ClN6O9Forma y color:SolidPeso molecular:587.02p-nitro-Pifithrin-α
CAS:<p>p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.</p>Fórmula:C15H16BrN3O3SForma y color:SolidPeso molecular:398.27SDZ 224-015
CAS:<p>SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.</p>Fórmula:C30H35Cl2N3O9Pureza:95.49% - 95.49%Forma y color:SolidPeso molecular:652.52VRT-043198
CAS:<p>VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.</p>Fórmula:C22H29ClN4O6Forma y color:SolidPeso molecular:480.94QM31
CAS:<p>QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).</p>Fórmula:C39H38Cl4N4O4Pureza:98%Forma y color:SolidPeso molecular:768.56N1,N11-Diethylnorspermine
CAS:<p>DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT & H2O2.</p>Fórmula:C13H32N4Forma y color:SolidPeso molecular:244.42GRI977143
CAS:<p>GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.</p>Fórmula:C22H17NO4SPureza:98.07%Forma y color:SolidPeso molecular:391.44OT-82
CAS:<p>OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.</p>Fórmula:C26H21FN4OPureza:98.91% - 99.315%Forma y color:SolidPeso molecular:424.47ML132
CAS:<p>ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).</p>Fórmula:C22H28ClN5O5Forma y color:SolidPeso molecular:477.94CZL55
CAS:<p>CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).</p>Fórmula:C20H22N2O6Pureza:98.19%Forma y color:SolidPeso molecular:386.4NLRP3 agonist 1
CAS:<p>Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.</p>Fórmula:C15H16N6Pureza:99.01%Forma y color:SolidPeso molecular:280.33M190S
CAS:<p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>Fórmula:C21H21N5O2Pureza:98%Forma y color:SolidPeso molecular:375.42Ac-YVAD-pNA
CAS:<p>Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].</p>Fórmula:C29H36N6O10Forma y color:SolidPeso molecular:628.639GDC-2394
CAS:<p>GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.</p>Fórmula:C20H25N5O4SForma y color:SolidPeso molecular:431.51CIL62
CAS:<p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>Fórmula:C23H26O5Pureza:97.07%Forma y color:SolidPeso molecular:382.45EP1013
CAS:<p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>Fórmula:C18H23FN2O6Pureza:98%Forma y color:SolidPeso molecular:382.38M867
CAS:<p>M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].</p>Fórmula:C27H43N7O6Pureza:98%Forma y color:SolidPeso molecular:561.67Ac-VAD-CHO
CAS:<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Fórmula:C14H23N3O6Pureza:98%Forma y color:SolidPeso molecular:329.35Z-YVAD-CMK
CAS:<p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>Fórmula:C30H37ClN4O9Pureza:98%Forma y color:SolidPeso molecular:633.09ZIF-8
CAS:<p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>Fórmula:C4H6N2ZnForma y color:SolidPeso molecular:147.513Caspase-3-IN-2
CAS:<p>Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.</p>Fórmula:C10H6ClNO5Forma y color:SolidPeso molecular:255.611N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
CAS:<p>N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.</p>Fórmula:C14H22Cl2N2O3SPeso molecular:369.31M826
<p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>Fórmula:C28H45N7O6Pureza:98%Forma y color:SolidPeso molecular:575.7Ac-DMLD-CMK
CAS:<p>Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.</p>Fórmula:C22H35ClN4O9SForma y color:SolidPeso molecular:567.053(2R,3S)-Emricasan
CAS:<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Fórmula:C26H27F4N3O7Forma y color:SolidPeso molecular:569.5Z-VA-DL-D-FMK
CAS:Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.Fórmula:C21H28FN3O7Forma y color:SolidPeso molecular:453.46
