Caspasa

Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, …

Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due …

Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, …

Oxidopamine hydrobromide is a neurotransmitter dopamine antagonist.

Oxidopamine hydrochloride is an neurotransmitter dopamine antagonist.

Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both …

Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is …

ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 …

Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties.

Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α …

Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).

Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor …

20-Hydroxyecdysone is a steroid hormone that regulates the processes of molting or ecdysis in insects.

Dehydrocorydaline chloride is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of …

Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such …

Cedrusin shows a cytotoxic effect on A375 and HeLa cells.

Isoverticine exhibits significant antitussive, expectorant and anti-inflammatory activities, it also displays significant cytotoxicity.

Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer …

2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), …

3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and …

Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis. Neocurdione shows a …

Ac-YVAD-CMK is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. …

Thevetiaflavone is a natural flavonoid from Wikstroemia indica that inhibits the leakage of lactate dehydrogenase …

Santamarine has significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking …

Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; …

Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.

δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead …

Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also …

Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of …

Regiolone demonstrates phytotoxicity. Regiolone also has anti-proliferative and apoptotic activities, it can induce apoptosis in …

Lucidenic acid B shows antioxidative, and anti-invasive effects, it inhibits PMA-induced invasion of human hepatoma …

Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma …

Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.

Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat …

Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis …

Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in …

Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO …

Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation …

Effusol is a natural product, exhibits potent scavenging activity for DPPH and ABTS radicals(IC50 values …

Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine.

Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration …

Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.

Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal …

Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis …

3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment …

Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.

Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent …

Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and …

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can …

Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory …

Furowanin A shows significant cytotoxicity against HL-60 cells, it induces that Caspase-9 and caspase-3 inhibitors …

Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of …

Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis …

Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors …

VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it …

Nivalenol is a fungal metabolite produced by Fusarium graminearum. Nivalenol induces cell death through caspase …

Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value …

Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia …

Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing …

Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle …

Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and …

15-acetoxyscirpenol is one of acetoxyscirpenol moiety mycotoxins (ASMs), showed strongly induces apoptosis and inhibits Jurkat …

Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly …

(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values …

Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and …

PQ401 suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).

3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adjuvant …

2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers …

3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.

Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane …

Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes …

Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active …

AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = …

(-)-Centrolobol has antifibrotic activity, it can significantly inhibit the proliferation of HSC-T6 cells in a …

28-Deoxonimbolide exhibits potent cytotoxic activity against HL60 leukemia cells.

Curzerenone holds great promise for use in chemopreventive and chemotherapeutic strategies, it has slightly effective …