Asociado a microtúbulos
Los inhibidores de proteínas asociadas a microtúbulos se dirigen a proteínas que interactúan con los microtúbulos, los componentes estructurales del citoesqueleto de la célula, esenciales para la división celular. Estas proteínas regulan la estabilidad y la dinámica de los microtúbulos durante la mitosis. Inhibir las proteínas asociadas a microtúbulos puede interrumpir la función de los microtúbulos, lo que lleva al arresto del ciclo celular y la apoptosis, particularmente en células cancerosas de rápida división. Estos inhibidores se utilizan ampliamente en la investigación del cáncer y el desarrollo de fármacos. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteínas asociadas a microtúbulos de alta calidad para apoyar su investigación en división celular, dinámica del citoesqueleto y terapia contra el cáncer.
Se han encontrado 283 productos de "Asociado a microtúbulos"
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TCS 2210
CAS:TCS 2210 promotes neuronal differentiation in stem cells, boosting β-III tubulin and enolase markers.Fórmula:C18H17N3O3Pureza:98.62%Forma y color:SolidPeso molecular:323.35Ref: TM-T23446
1mg90,00€2mg123,00€5mg182,00€10mg274,00€25mg469,00€50mg643,00€100mg914,00€500mg1.833,00€1mL*10mM (DMSO)187,00€DM1-SMe
CAS:DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.
Fórmula:C36H50ClN3O10S2Pureza:99.61%Forma y color:SolidPeso molecular:784.38JH-VIII-157-02
CAS:JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.Fórmula:C28H27N5O2Pureza:99.58%Forma y color:SolidPeso molecular:465.55Ref: TM-T15612
1mg116,00€5mg240,00€10mg358,00€25mg558,00€50mg753,00€100mg1.035,00€1mL*10mM (DMSO)246,00€JG-23
CAS:JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) ofFórmula:C19H16ClN3OS2Forma y color:SolidPeso molecular:401.93Oxaline
CAS:Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].Fórmula:C24H25N5O4Forma y color:SolidPeso molecular:447.49N-Deacetylcolchicine
CAS:Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.Fórmula:C20H23NO5Forma y color:SolidPeso molecular:357.4Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
CAS:Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau inFórmula:C38H65N11O9Forma y color:SolidPeso molecular:819.99Anticancer agent 40
CAS:Anticancer agent 3e targets SKBR-3, SKOV-3, PC-3, U-87 (IC50 ~0.95 nM) and HDF cells (IC50: 2.13 nM).Fórmula:C25H29NO6Forma y color:SolidPeso molecular:439.5THK-5105
CAS:THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.Fórmula:C20H21FN2O2Forma y color:SolidPeso molecular:340.39Tubulin polymerization-IN-52
CAS:Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization, exhibiting an IC50 value of 2.9 μM [1].Fórmula:C21H18F3N5O3Forma y color:SolidPeso molecular:445.39Valecobulin hydrochloride
CAS:Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516.Cost-effective and quality-assured.Fórmula:C26H29ClN6O5SPureza:99.52%Forma y color:SolidPeso molecular:573.06Ref: TM-T13278
1mg88,00€5mg170,00€10mg259,00€25mg429,00€50mg605,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)207,00€ASN90
CAS:ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM.Fórmula:C17H21N5O3SForma y color:SolidPeso molecular:375.45MK-6240
CAS:MK-6240: A tau PET tracer with high specificity for NFTs binding.Fórmula:C16H11FN4Pureza:98%Forma y color:SolidPeso molecular:278.28Antitumor agent-67
CAS:Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells.Fórmula:C45H47NO13Forma y color:SolidPeso molecular:809.85CNS-11
CAS:CNS-11, a compound that disaggregates tau fibrils, is utilized in Alzheimer's disease (AD) research [1].Fórmula:C25H21N3O2Forma y color:SolidPeso molecular:395.453,4',5-Trismethoxybenzophenone
CAS:3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1].Fórmula:C16H16O4Forma y color:SolidPeso molecular:272.3Dolastatinol
CAS:Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.Fórmula:C43H70N6O7SForma y color:SolidPeso molecular:815.12PBB3
CAS:PBB3 is a tau-specific PET tracer.Fórmula:C17H15N3OSForma y color:SolidPeso molecular:309.39Tubulin inhibitor 25
CAS:Potent Tubulin inhibitor 25: IC50 0.98 μM, blocks HT29 cell growth, hinders cell migration & microtubule formation, anti-angiogenic.Fórmula:C26H22O8Forma y color:SolidPeso molecular:462.45Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Fórmula:C32H59ClN6O5Pureza:98%Forma y color:SolidPeso molecular:643.30
