ROCK
Los inhibidores de la quinasa asociada a Rho (ROCK) se dirigen a las quinasas ROCK, que están involucradas en la regulación del citoesqueleto, la forma celular y la motilidad. ROCK desempeña un papel significativo en el control de la división celular, particularmente en procesos como la citocinesis. Inhibir ROCK puede provocar cambios en la dinámica del ciclo celular, la motilidad celular y la apoptosis, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer, la neurobiología y los estudios cardiovasculares. En CymitQuimica, ofrecemos una selección de inhibidores de ROCK de alta calidad para apoyar su investigación en biología celular, dinámica del citoesqueleto y mecanismos de enfermedades.
Se han encontrado 66 productos para "ROCK".
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Y-33075 dihydrochloride
CAS:Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Fórmula:C16H18Cl2N4OPureza:98.88% - 99.89%Forma y color:SolidPeso molecular:353.246ROCK inhibitor-2
CAS:ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Fórmula:C21H20N2O2Pureza:99.85%Forma y color:SolidPeso molecular:332.3957Netarsudil Dihydrochloride
CAS:Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Fórmula:C28H29Cl2N3O3Pureza:99.92% - 99.98%Forma y color:White SolidPeso molecular:526.454CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:99.01% - 99.52%Forma y color:SolidPeso molecular:466.46ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Fórmula:C28H30N8O2Forma y color:SolidPeso molecular:510.59WAY-656935
CAS:WAY-656935 inhibits ROCK.Fórmula:C20H28ClN3O3SPureza:97%Forma y color:SolidPeso molecular:425.973Y-39983 hydrochloride
CAS:Y-39983 hydrochloride (SNJ-1656) is a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor.Fórmula:C16H17ClN4OPeso molecular:316.79Ripasudil free base
CAS:Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.Fórmula:C15H18FN3O2SPureza:98%Forma y color:SolidPeso molecular:323.386Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.84% - 99.97%Forma y color:White SolidPeso molecular:291.369ROCK2-IN-11
ROCK2-IN-11 (Compound A20) is a selective ROCK2 inhibitor with an IC50 of 0.18 μM against ROCK2, demonstrating greater potency over ROCK1. It is applicable in the research of idiopathic pulmonary fibrosis and chronic graft-versus-host disease (cGVHD).S6(229-239), Amide, biotinalyted
S6(229-239), Amide, biotinylated, is a bioactive peptide known as a substrate for Rho-kinase II.Fórmula:C64H119N27O15SPeso molecular:1537.90997GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.Fórmula:C15H13Cl2N3Pureza:98.1%Forma y color:SolidPeso molecular:306.19Verosudil
CAS:Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Fórmula:C17H17N3O2SPureza:99.68%Forma y color:SolidPeso molecular:327.401GSK269962A hydrochloride
CAS:GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Fórmula:C29H31ClN8O5Forma y color:SolidPeso molecular:607.06Cotosudil
CAS:Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Fórmula:C16H21N3O2SPureza:98.41%Forma y color:SolidPeso molecular:319.422Belumosudil mesylate
CAS:Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.Fórmula:C27H28N6O5SPureza:99.36%Forma y color:SolidPeso molecular:548.61SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Fórmula:C14H16N2O2Pureza:99.42%Forma y color:White SolidPeso molecular:244.289RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFórmula:C17H16N4O2SPureza:99.70% - ≥95%Forma y color:White SolidPeso molecular:340.4ROCK-IN-2
CAS:ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.Fórmula:C18H13ClF2N6OPureza:97.29%Forma y color:SolidPeso molecular:402.79SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFórmula:C14H17ClN2O2Pureza:99.15%Forma y color:SolidPeso molecular:280.75
