HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Se han encontrado 177 productos para "HSP".
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CC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Fórmula:C22H20ClN5O3SPureza:99.59%Forma y color:SolidPeso molecular:469.94Ethoxyquin
CAS:Producto controladoEthoxyquin (Santoflex) is an antioxidant used in animal feeds.Fórmula:C14H19NOPureza:97.15% - 98.73%Forma y color:Yellow LiquidPeso molecular:217.31IPI-493
CAS:IPI-493 is a bioactive chemical.Fórmula:C28H39N3O8Pureza:99.86%Forma y color:SolidPeso molecular:545.62Novobiocin Sodium
CAS:Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Fórmula:C31H35N2NaO11Pureza:99% - 99.51%Forma y color:SolidPeso molecular:634.61Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Fórmula:C14H11NO4Pureza:99.03% - 99.96%Forma y color:SolidPeso molecular:257.24Ref: TM-T10860
2mg44,00€5mg66,00€1mL*10mM (DMSO)66,00€10mg102,00€25mg205,00€50mg333,00€100mg513,00€200mg737,00€500mg1.108,00€Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.44% - 99.98%Forma y color:SolidPeso molecular:429.85GRP78-IN-3
CAS:GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Fórmula:C17H18N4O2SPureza:99.49%Forma y color:SolidPeso molecular:342.42MAL3-101
CAS:MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).Fórmula:C54H66N4O10Forma y color:SolidPeso molecular:931.12p5 Ligand for Dnak and DnaJ
CAS:P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.Fórmula:C44H81N15O11SPureza:98%Forma y color:SolidPeso molecular:1028.27HA15-Biotin
CAS:HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.Fórmula:C37H45N7O5S3Forma y color:SolidPeso molecular:763.99TBPH
TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.Myrtucommulone
CAS:Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Fórmula:C38H52O10Pureza:98%Forma y color:SolidPeso molecular:668.81NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Fórmula:C22H22N4O7Pureza:99.84%Forma y color:SolidPeso molecular:454.43Ref: TM-T6609
2mg39,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg92,00€25mg187,00€50mg294,00€100mg419,00€200mg590,00€PROTAC HSP90 degrader BP3
CAS:PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.Fórmula:C32H29ClN8O5Forma y color:SolidPeso molecular:641.08HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Fórmula:C57H71N15O6Forma y color:SolidPeso molecular:1062.27HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Pureza:98%Forma y color:Odour SolidAlvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Fórmula:C34H49F3N4O10Forma y color:SolidPeso molecular:730.340086BrCaQ-C10-TPP
6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.Fórmula:C45H47Br2N2O3PForma y color:SolidPeso molecular:854.65trans-Dehydrocurvularin
CAS:trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Fórmula:C16H18O5Forma y color:SolidPeso molecular:290.3153-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Fórmula:C13H11N5O2Pureza:99.88%Forma y color:SolidPeso molecular:269.26
