HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Se han encontrado 197 productos para "HSP".
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GRP78-IN-3
CAS:GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Fórmula:C17H18N4O2SPureza:99.49%Forma y color:SolidPeso molecular:342.415IPI-493
CAS:IPI-493 is a bioactive chemical.Fórmula:C28H39N3O8Pureza:99.86%Forma y color:SolidPeso molecular:545.62CC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Fórmula:C22H20ClN5O3SPureza:99.59%Forma y color:SolidPeso molecular:469.944Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Fórmula:C14H11NO4Pureza:99.03% - 99.96%Forma y color:SolidPeso molecular:257.2414Novobiocin Sodium
CAS:Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Fórmula:C31H35N2NaO11Pureza:99% - 99.51%Forma y color:SolidPeso molecular:634.6062Ethoxyquin
CAS:Producto controladoEthoxyquin (Santoflex) is an antioxidant used in animal feeds.Fórmula:C14H19NOPureza:97.15% - 98.73%Forma y color:Yellow LiquidPeso molecular:217.3068Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.44% - 99.98%Forma y color:SolidPeso molecular:429.852Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Fórmula:C34H49F3N4O10Forma y color:SolidPeso molecular:730.34008Hsp90β-IN-2
Hsp90β-IN-2 (Compound 16B) is a selective inhibitor of Hsp90β, with dissociation constants (KD) of 225 nM for Hsp90β and 73.32 μM for Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231, A549, and SKOV-3 cells, and is applicable in research on triple-negative breast cancer.Cemdomespib
CAS:Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.Fórmula:C24H30FNO6Forma y color:SolidPeso molecular:447.5TBPH
TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.3-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Fórmula:C13H11N5O2Pureza:99.88%Forma y color:SolidPeso molecular:269.2587NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Fórmula:C22H22N4O7Pureza:99.84%Forma y color:Yellow SolidPeso molecular:454.4327[Au(TPP)]Cl
CAS:[Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and exhibits anticancer properties.'Fórmula:C44H28AuClN4Peso molecular:845.14JG-258
CAS:JG-258 is an inactive negative control for Hsp70 inhibitors [1] .Fórmula:C20H22ClN3OS3Forma y color:SolidPeso molecular:452.06trans-Dehydrocurvularin
CAS:trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Fórmula:C16H18O5Forma y color:SolidPeso molecular:290.315Grp94 Inhibitor-2
Grp94 Inhibitor-2 (compound 23) is a cyclopropane analog that exhibits high affinity for Glucose Regulated Protein 94 (Grp94), with dissociation constants (Kd) of 0.48 µM for Grp94 and 0.65 µM for Hsp90α.Fórmula:C26H25ClFNO4Peso molecular:469.946BrCaQ-C10-TPP
6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.Fórmula:C45H47Br2N2O3PForma y color:SolidPeso molecular:854.65HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Fórmula:C57H71N15O6Forma y color:SolidPeso molecular:1062.27Grp94-IN-3
Grp94-IN-3 (Compound 47) is a selective Grp94 ATP-competitive inhibitor with a dissociation constant (Kd) of 76 nM. It exhibits significantly lower affinity for Hsp90α, with a Kd of 9.17 μM. Grp94-IN-3 induces degradation of Integrin α2 (Integrinα2) in MDA-MB-231 cells and reduces intracellular accumulation of mutant myocilin in human trabecular meshwork cells. This compound is useful in research on metastatic cancers and open-angle glaucoma.
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