Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2238 productos de "Cromatina / Epigenética"
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mTOR/HDAC-IN-1
CAS:<p>mTOR/HDAC-IN-1, a dual inhibitor for mTOR & HDAC1 with IC50s 0.49 & 0.91 nM, potential anti-cancer agent.</p>Fórmula:C23H23N11O3Forma y color:SolidPeso molecular:501.5KAT6-IN-2
<p>KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.</p>Forma y color:Odour SoliddAURK-4
CAS:<p>dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].</p>Fórmula:C52H52ClFN8O12Forma y color:SolidPeso molecular:1035.47HD-TAC7
<p>HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB p65; researched for asthma, COPD.</p>Fórmula:C33H32FN7O7Forma y color:SolidPeso molecular:657.65MT1
CAS:<p>MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).</p>Fórmula:C54H66Cl2N10O9S2Forma y color:SolidPeso molecular:1134.2XF056-132
CAS:<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Fórmula:C51H57F4N9O7SForma y color:SolidPeso molecular:1016.11PROTAC SMARCA2/4-degrader-26
<p>PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.</p>Fórmula:C38H47N9O5SForma y color:SolidPeso molecular:741.9PROTAC BRD9-binding moiety 1
CAS:<p>PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.</p>Fórmula:C23H25N3O7S2Pureza:98%Forma y color:SolidPeso molecular:519.59(S,R,S)-AHPC-C5-COOH
CAS:<p>E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.</p>Fórmula:C29H42N4O5SPureza:98%Forma y color:SolidPeso molecular:558.73PROTAC SMARCA2/4-degrader-27
CAS:<p>PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.</p>Fórmula:C49H58FN9O6SForma y color:SolidPeso molecular:920.11Retreversine
CAS:<p>Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.</p>Fórmula:C21H27N7OForma y color:SolidPeso molecular:393.49CBP/p300-IN-14
CAS:<p>CBP/p300-IN-14, patent WO2021213521A1's compound 27, inhibits CBP/EP300 with 3.3 nM IC50.</p>Fórmula:C30H31F2N7O2Forma y color:SolidPeso molecular:559.622Ep300/CREBBP-IN-2
CAS:<p>Ep300/CREBBP-IN-2: Potent, oral Ep300 & CREBBP inhibitor; IC50s: 0.052μM & 0.148μM; cancer research.</p>Fórmula:C26H27F3N4O4Forma y color:SolidPeso molecular:516.51SIRT1/2/3-IN-1
CAS:<p>Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.</p>Fórmula:C46H63N9O8S2Forma y color:SolidPeso molecular:934.18NF-κB/HIF-1α-IN-1
<p>NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.</p>Fórmula:C24H27N7O4Forma y color:SolidPeso molecular:477.21245MZP-55
CAS:<p>MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)</p>Fórmula:C57H70ClN7O10SPureza:98%Forma y color:SolidPeso molecular:1080.73RJW100
CAS:<p>RJW100 is a potent LRH-1 & SF-1 agonist with pEC50 of 6.6 & 7.5, also activates miR-200c promoter.</p>Fórmula:C28H34OPureza:99.15%Forma y color:SolidPeso molecular:386.57CD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Forma y color:SolidZIP
CAS:<p>Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.</p>Fórmula:C90H154N30O17Pureza:98%Forma y color:SolidPeso molecular:1928.4
