Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2235 productos de "Cromatina / Epigenética"
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(Z)-SMI-4a
CAS:<p>(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.</p>Fórmula:C11H6F3NO2SPureza:97.66% - 99.93%Forma y color:SolidPeso molecular:273.23Oclacitinib
CAS:<p>Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000</p>Fórmula:C15H23N5O2SPureza:98% - 98.45%Forma y color:White To Off-White SolidPeso molecular:337.44lutidinic acid
CAS:<p>lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.</p>Fórmula:C7H5NO4Pureza:98.06%Forma y color:White To Off-White Crystalline PowderPeso molecular:167.12RG108
CAS:<p>RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).</p>Fórmula:C19H14N2O4Pureza:98% - 99.43%Forma y color:SolidPeso molecular:334.33SGC-CBP30
CAS:<p>SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).</p>Fórmula:C28H33ClN4O3Pureza:99.05% - >99.99%Forma y color:SolidPeso molecular:509.04AZD-1480
CAS:<p>AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.</p>Fórmula:C14H14ClFN8Pureza:98.25% - 99.47%Forma y color:SolidPeso molecular:348.77JAK-IN-5 hydrochloride
CAS:<p>JAK-IN-5 hydrochloride is a JAK inhibitor [1].</p>Fórmula:C27H32ClFN6OForma y color:SolidPeso molecular:511.03Barasertib-HQPA
CAS:<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Fórmula:C26H30FN7O3Pureza:98.43% - 99.29%Forma y color:SolidPeso molecular:507.56ARV-825
CAS:<p>ARV-825: PROTAC recruits BRD4 to cereblon for rapid BRD4 degradation in all tested BL cells.</p>Fórmula:C46H47ClN8O9SPureza:97.15% - 98%Forma y color:SolidPeso molecular:923.43UNC6934
CAS:<p>UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.</p>Fórmula:C24H21N5O4Pureza:98.67%Forma y color:SolidPeso molecular:443.45Annaosanchun
CAS:<p>Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).</p>Fórmula:C19H32O3Pureza:99.58%Forma y color:SolidPeso molecular:308.46GS-829845
CAS:<p>GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life</p>Fórmula:C17H19N5O2SPureza:99.93%Forma y color:SolidPeso molecular:357.43CX-6258 hydrochloride
CAS:<p>CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).</p>Fórmula:C26H24ClN3O3·HClPureza:96.03% - 98.60%Forma y color:SolidPeso molecular:498.4CBHcy
CAS:<p>CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.</p>Fórmula:C9H17NO4SPureza:>99.99% - >99.99%Forma y color:SolidPeso molecular:235.3TNG-462
CAS:<p>TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).</p>Fórmula:C28H36N6O2SPureza:98.7%Forma y color:SolidPeso molecular:520.69MIV-6R
CAS:<p>MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.</p>Fórmula:C27H35N3OPureza:99.81% - 99.88%Forma y color:SolidPeso molecular:417.59Talazoparib tosylate
CAS:<p>PF-3882845 is an MR antagonist that binds to the progesterone receptor (PR) and is used in the study of endocrine disorders and urogenital disorders.</p>Fórmula:C26H22F2N6O4SPureza:99.79%Forma y color:SolidPeso molecular:552.55Zavondemstat
CAS:<p>Zavondemstat (QC8222 free base) is a KDM4 inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.</p>Fórmula:C26H29N3O3Pureza:99.43% - 99.53%Forma y color:SolidPeso molecular:431.53MS023 dihydrochloride
CAS:<p>MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.</p>Fórmula:C17H27Cl2N3OPureza:99.52%Forma y color:SolidPeso molecular:360.32Cerdulatinib hydrochloride
CAS:<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Fórmula:C20H28ClN7O3SPureza:99.85%Forma y color:SolidPeso molecular:482Chromium(III) acetate
CAS:<p>Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.</p>Fórmula:C2H3O2CrPureza:99.9%Forma y color:Blue-Green Powder Environment Immediate Steps Should Be Taken To Limit Its Spread To The Environment It Is Used InPeso molecular:76.37(S)-HH2853
CAS:<p>(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.</p>Fórmula:C31H36F3N7O3Pureza:97.18% - 99.74%Forma y color:SolidPeso molecular:611.66MRK-740
CAS:<p>MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.</p>Fórmula:C25H32N6O3Pureza:99.66%Forma y color:SolidPeso molecular:464.56BI-9321 trihydrochloride
CAS:<p>BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.</p>Fórmula:C22H24Cl3FN4Pureza:99.12% - 99.34%Forma y color:SolidPeso molecular:469.81R 59-022
CAS:<p>R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.</p>Fórmula:C27H26FN3OSPureza:98.55%Forma y color:SolidPeso molecular:459.58PFI-2
CAS:<p>PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other</p>Fórmula:C23H25F4N3O3SPureza:99.38%Forma y color:SolidPeso molecular:499.52NVP-BSK805
CAS:<p>NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.</p>Fórmula:C27H28F2N6OPureza:98%Forma y color:SolidPeso molecular:490.55MK-5108
CAS:<p>MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.</p>Fórmula:C22H21ClFN3O3SPureza:99.22%Forma y color:SolidPeso molecular:461.94Dehydrocorydaline nitrate
CAS:<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Fórmula:C22H24N2O7Pureza:99.79% - 99.92%Forma y color:SolidPeso molecular:428.44SCH-1473759 hydrochloride
CAS:<p>SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).</p>Fórmula:C20H27ClN8OSPureza:98.29%Forma y color:SolidPeso molecular:463GSK2807 Trifluoroacetate
CAS:<p>GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).</p>Fórmula:C21H33F3N8O7Pureza:99.95%Forma y color:SolidPeso molecular:566.53(R)-Dihydrolipoic acid
CAS:<p>(R)-Dihydrolipoic acid, the biochemically significant R-enantiomer, partakes in biochemical transformations.</p>Fórmula:C8H16O2S2Pureza:98%Forma y color:SolidPeso molecular:208.33Solrikitug
CAS:<p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>Pureza:95%Forma y color:LiquidTazemetostat trihydrochloride
CAS:<p>Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.</p>Fórmula:C34H47Cl3N4O4Pureza:98%Forma y color:SolidPeso molecular:682.12Acedapsone
CAS:<p>Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.</p>Fórmula:C16H16N2O4SPureza:98%Forma y color:SolidPeso molecular:332.37Diethyl bipy55'DC
CAS:<p>"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."</p>Fórmula:C16H16N2O4Pureza:98%Forma y color:SolidPeso molecular:300.312-PADQZ
CAS:<p>DPQ is an antiviral compound.</p>Fórmula:C14H19N5O2Pureza:98%Forma y color:White PowderPeso molecular:289.33Nicotinamide-d4
CAS:<p>Nicotinamide-d4 is a deuterium-labelled compound of nicotinamide for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.</p>Fórmula:C6H2D4N2OPureza:99.746%Forma y color:SolidPeso molecular:126.15193 D7
CAS:<p>193 D7 is an inhibitor of histone demethylase JMJD1C (IC50= 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumors by targeting intratumoral Treg cells in mouse tumor models.</p>Fórmula:C16H15NO4SForma y color:SolidPeso molecular:317.36GSK 4027
CAS:<p>GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.</p>Fórmula:C17H21BrN4OForma y color:SolidPeso molecular:377.28I-BET787
CAS:<p>I-BET787, an orally active pan-BET bromodomain inhibitor, has demonstrated efficacy in murine inflammation models.</p>Fórmula:C16H20ClN3O2Forma y color:SolidPeso molecular:321.80CrBKA
CAS:<p>CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity [1] .</p>Fórmula:C28H31N3O6Forma y color:SolidPeso molecular:505.56AdipoR agonist 1
CAS:<p>AdipoR agonist 1 (Compound 112254), acting as an agonist for the adiponectin receptor (AdipoR), stimulates transcriptional regulators including peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). It is employed in the field of preventive doping research.</p>Fórmula:C26H35N3O3Forma y color:SolidPeso molecular:437.57HDAC6-IN-27
CAS:<p>HDAC6-IN-27 (compound 8C), an HDAC inhibitor, exhibits IC 50 values of 15.9 nM, 136.5 nM, and 6180.2 nM against HDAC6, HDAC8, and HDAC1, respectively. It also demonstrates potent antiparasitic effects [1].</p>Fórmula:C15H15N3O4Forma y color:SolidPeso molecular:301.3BG47
CAS:<p>BG47: a COMET probe for precise optical epigenetic control, inhibits histone deacetylases with light.</p>Fórmula:C25H22N4O2SForma y color:SolidPeso molecular:442.54Guanosine-5'-triphosphate disodium salt
CAS:<p>5'-GTP disodium salt boosts myogenic differentiation and fuels cellular processes.</p>Fórmula:C10H14N5Na2O14P3Pureza:95.69% - 99.96%Forma y color:Odorless White SolidPeso molecular:567.14GSK-J1 lithium salt
CAS:<p>GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.</p>Fórmula:C22H22LiN5O2Pureza:98%Forma y color:SolidPeso molecular:395.38BG14
CAS:<p>BG14: High-res optical epigenetic control; photo-inhibits human histone deacetylases with visible light.</p>Fórmula:C21H21N5OForma y color:SolidPeso molecular:359.433KAT6-IN-1
CAS:<p>KAT6-IN-1 is a potent KAT6 inhibitor. KAT6-IN-1 can be used in research of cancer [1] .</p>Fórmula:C19H18N4O5SForma y color:SolidPeso molecular:414.43ZM39923
CAS:<p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>Fórmula:C23H25NOPureza:98%Forma y color:SolidPeso molecular:331.45
