Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2242 productos de "Cromatina / Epigenética"
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CRV431
CAS:<p>CRV431 is a novel Pan-Cyclophilin Inhibitor, potently inhibiting all cyclophilin isoforms tested - A, B, D, and G (IC50 values ranged from 1-7 nM).</p>Fórmula:C67H122N12O13Forma y color:SolidPeso molecular:1303.76Sapintoxin D
CAS:<p>Sapintoxin D is a fluorescent phorbol ester and selective activator of protein kinase C.</p>Fórmula:C30H37NO8Forma y color:SolidPeso molecular:539.62Hesperadin hydrochloride
<p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>Fórmula:C29H33ClN4O3SForma y color:SolidPeso molecular:553.12EZH2-IN-12
<p>EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.</p>Fórmula:C23H23Cl2N3O3Forma y color:SolidPeso molecular:460.355-Ph-IAA-AM
<p>5-Ph-IAA-AM, eggshell-permeable analog of 5-Ph-IAA, boosts protein degradation in embryos, useful for studying proteins in C. elegans.</p>Fórmula:C19H17NO4Forma y color:SolidPeso molecular:323.34(2S,3R)-LP99
CAS:<p>(2S,3R)-LP99 is a less active enantiomer of LP99.</p>Fórmula:C26H30ClN3O4SPureza:98%Forma y color:SolidPeso molecular:516.05PARP1-IN-5
<p>PARP1-IN-5 is a potent, selective, orally active, low-toxicity PARP-1 inhibitor with an IC50 value of 14.7 nM. PARP1-IN-5 can be used in cancer research.</p>Fórmula:C25H24N2O5SForma y color:SolidPeso molecular:464.53PARP7-IN-12
CAS:<p>PARP7-IN-12, a potent inhibitor targeting PARP7, exhibits an IC50 of 7.836 nM. This compound is applicable in cancer research.</p>Fórmula:C23H27ClF3N5O5Forma y color:SolidPeso molecular:545.94BET-IN-1
<p>BET-IN-1 is a potent inhibitor of BET, exhibiting good brain permeability and a reasonable metabolic stability.</p>Fórmula:C23H24ClFN4O3SForma y color:SolidPeso molecular:490.98HDAC6-IN-12
<p>HDAC6-IN-12 is a potent inhibitor of HDAC6 that binds in the DNA chain, causing DNA damage and exhibiting anticancer effects that can be used in cancer research</p>Fórmula:C24H39F2N3O5Forma y color:SolidPeso molecular:487.58KDOAM-25 trihydrochloride
<p>KDOAM-25 trihydrochloride selectively inhibits KDM5 enzymes, boosts H3K4 methylation, and suppresses MM1S cell growth.</p>Fórmula:C15H28Cl3N5O2Forma y color:SolidPeso molecular:416.77LSD1-IN-19
<p>LSD1-IN-19 is a potent, selective LSD1 inhibitor with Ki of 0.108 μM and 72h IC50 values of 0.17-0.40 μM.</p>Fórmula:C33H42N6O2Forma y color:SolidPeso molecular:554.73B026
CAS:<p>B026: Oral p300/CBP HAT inhibitor, IC50: p300 1.8 nM, CBP 9.5 nM; targets AR+ prostate cancer cells.</p>Fórmula:C27H23F4N5O4Forma y color:SolidPeso molecular:557.5BET-IN-8
<p>BET-IN-8 (Compound 27) is a potent inhibitor of BET (Ki: 0.83 μM, Kd: 0.571 μM), which ameliorates LPS-induced sepsis in vivo.BET-IN-8 has shown potential in</p>Fórmula:C22H21N3O4SForma y color:SolidPeso molecular:423.48EED ligand 1
<p>EED ligand 1: potent PRC2 inhibitor targeting EED subunit.</p>Fórmula:C19H19FN8OForma y color:SolidPeso molecular:394.41MDH1/2-IN-1
CAS:<p>MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.</p>Fórmula:C25H33NO4Forma y color:SolidPeso molecular:411.534DS17701585
<p>DS17701585: Oral EP300/CBP inhibitor; potent on CBP, EP300, H3K27, & SOX2; useful for cancer research.</p>Fórmula:C24H26N4O5SForma y color:SolidPeso molecular:482.55BRD4-BD1/2-IN-2
CAS:<p>BRD4-BD1/2-IN-2 inhibits BRD4 BD1/BD2 with IC50 <300 nM/<0.5 nM (WO2021233371A1).</p>Fórmula:C30H33N5O4Forma y color:SolidPeso molecular:527.61HDAC2-IN-1
<p>HDAC2-IN-1 is an oral HDAC2 inhibitor (IC50: 0.5 μM), crosses the blood-brain barrier, and inhibits HDAC1 and HDAC8.</p>Fórmula:C22H23ClN4OSForma y color:SolidPeso molecular:426.96HDAC-IN-33
<p>HDAC-IN-33 inhibits HDAC1/2/6 (IC50: 24/46/47 nM), exhibits potent antitumor activity in vitro and in vivo, and activates antitumor immunity.</p>Fórmula:C21H25N3O3Forma y color:SolidPeso molecular:367.44
