Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2245 productos de "Cromatina / Epigenética"
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(2S,3R)-LP99
CAS:(2S,3R)-LP99 is a less active enantiomer of LP99.Fórmula:C26H30ClN3O4SPureza:98%Forma y color:SolidPeso molecular:516.05PARP1-IN-5
<p>PARP1-IN-5 is a potent, selective, orally active, low-toxicity PARP-1 inhibitor with an IC50 value of 14.7 nM. PARP1-IN-5 can be used in cancer research.</p>Fórmula:C25H24N2O5SForma y color:SolidPeso molecular:464.535-Ph-IAA-AM
<p>5-Ph-IAA-AM, eggshell-permeable analog of 5-Ph-IAA, boosts protein degradation in embryos, useful for studying proteins in C. elegans.</p>Fórmula:C19H17NO4Forma y color:SolidPeso molecular:323.34O-Desmethyl Midostaurin
CAS:O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism.Fórmula:C34H28N4O4Pureza:98%Forma y color:SolidPeso molecular:556.61AZ-3
CAS:<p>AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).</p>Fórmula:C20H28FN7Pureza:98%Forma y color:SolidPeso molecular:385.48SIRT1-IN-5
CAS:<p>SIRT1-IN-5 (215) is a modulator of the NAD-dependent protein deacetylase SIRT1.</p>Fórmula:C21H17N3O3SForma y color:SolidPeso molecular:391.443EBET-590
CAS:<p>EBET-590 is a BET inhibitor utilized in cancer research.</p>Fórmula:C26H26N4O3Peso molecular:442.51EN884
CAS:EN884 is a BRD4 degrader that functions through an SKP1 and proteasome-dependent degradation pathway. It is utilized in the synthesis of proteolysis-targeting chimeras (PROTAC).Fórmula:C14H18N2OPeso molecular:230.31SMARCA2-IN-6
CAS:<p>SMARCA2-IN-6 is a potent inhibitor of SMARCA2 (also known as BRM), exhibiting an IC50 of less than 5 nM against both SMARCA2 and SMARCA4. Additionally, this compound suppresses the expression of the KRT80 gene in H1299 cells with an IC50 of 26 nM and inhibits the proliferation of SKMEL5 cells carrying a BRG1 mutation with an IC50 value of 13 nM.</p>Fórmula:C10H8ClF2N5OSForma y color:SolidPeso molecular:319.72PARP7-IN-12
CAS:<p>PARP7-IN-12, a potent inhibitor targeting PARP7, exhibits an IC50 of 7.836 nM. This compound is applicable in cancer research.</p>Fórmula:C23H27ClF3N5O5Forma y color:SolidPeso molecular:545.94RU-0415529
CAS:<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Fórmula:C21H29N3O4SForma y color:SolidPeso molecular:419.538BRD4 D1-IN-2
<p>BRD4 D1-IN-2 (compound 26), a BRD4 D1 inhibitor, IC50 <0.092 μM, 15 nM affinity, >500x selectivity over BRD2 D1/BRD4 D2.</p>Fórmula:C33H39F3N6OForma y color:SolidPeso molecular:592.7BET-IN-1
<p>BET-IN-1 is a potent inhibitor of BET, exhibiting good brain permeability and a reasonable metabolic stability.</p>Fórmula:C23H24ClFN4O3SForma y color:SolidPeso molecular:490.98GSK852
<p>GSK852 is a potent, second bromodomain (BD2)-selective, bromo and extra-terminal domain (BET) inhibitor with pIC50 of 7.9.</p>Fórmula:C24H26N2O4Forma y color:SolidPeso molecular:406.47HDAC6-IN-12
<p>HDAC6-IN-12 is a potent inhibitor of HDAC6 that binds in the DNA chain, causing DNA damage and exhibiting anticancer effects that can be used in cancer research</p>Fórmula:C24H39F2N3O5Forma y color:SolidPeso molecular:487.58KDOAM-25 trihydrochloride
<p>KDOAM-25 trihydrochloride selectively inhibits KDM5 enzymes, boosts H3K4 methylation, and suppresses MM1S cell growth.</p>Fórmula:C15H28Cl3N5O2Forma y color:SolidPeso molecular:416.77LSD1-IN-19
<p>LSD1-IN-19 is a potent, selective LSD1 inhibitor with Ki of 0.108 μM and 72h IC50 values of 0.17-0.40 μM.</p>Fórmula:C33H42N6O2Forma y color:SolidPeso molecular:554.73MAO A/HDAC-IN-1
<p>MAO A/HDAC-IN-1 is an effective monoamine oxidase A (MAO A) and HDAC dual inhibitor, which can be used for glioma research.</p>Fórmula:C21H24ClN3O3Forma y color:SolidPeso molecular:401.89QCA570
CAS:<p>QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).</p>Fórmula:C39H33N7O4SPureza:98%Forma y color:SolidPeso molecular:695.79PARP-1-IN-1
<p>PARP-1-IN-1: Selective, oral PARP-1 inhibitor with 0.96 nM IC50; well-tolerated and effective in single-dose MDA-MB-436 model.</p>Fórmula:C23H25FN4OForma y color:SolidPeso molecular:392.47
