Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2553 productos de "Cromatina / Epigenética"
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MRK-740-NC
CAS:MRK-740-NC is an inhibitor of the PRDM7/9 histone methyltransferase. Acting as the negative control compound for MRK-740, MRK-740-NC lacks inhibitory activity on PRDM7 and PRDM9 because the methylpyridine portion of MRK-740 is replaced with a phenyl group.Fórmula:C25H31N5O3Forma y color:SolidPeso molecular:449.55CARM1-IN-3 dihydrochloride
CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).Fórmula:C24H34Cl2N4O2Forma y color:SolidPeso molecular:481.46HDAC-IN-87
CAS:HDAC-IN-87 (Compound XII6) is a non-selective HDAC inhibitor with pIC50 values of 6.9 for HDAC4 and 5.8 for HDAC6. It exhibits fungicidal activity against P. sorghi and P. pachyrhizi. The acute oral LD50 in both male and female rats is greater than 500 mg/kg.Fórmula:C13H7F5N4O2SForma y color:SolidPeso molecular:378.277HIF-2α-IN-5
CAS:HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].Fórmula:C15H12F4O3S2Forma y color:SolidPeso molecular:380.38YEATS4 binder-1
YEATS4 binder-1(4e) is an effective and selective compound that targets the KAc recognition site within the YEATS structural domain, exhibiting a bindingFórmula:C23H34N4O3Forma y color:SolidPeso molecular:414.54PRMT5-IN-19
PRMT5-IN-19 is a potent, selective PRMT5 inhibitor with IC50 of 23.9 nM and 47 nM, showing anti-cancer activity by inducing apoptosis.Fórmula:C25H24N4OForma y color:SolidPeso molecular:396.48CRV431
CAS:CRV431 is a novel Pan-Cyclophilin Inhibitor, potently inhibiting all cyclophilin isoforms tested - A, B, D, and G (IC50 values ranged from 1-7 nM).Fórmula:C67H122N12O13Forma y color:SolidPeso molecular:1303.76PRMT5-IN-18
CAS:PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Fórmula:C32H42N4O4Forma y color:SolidPeso molecular:546.70MAT2A-IN-18
CAS:MAT2A-IN-18 (Compound 15) is an inhibitor of methionine adenosyltransferase 2A (MAT2A) with an IC50 of 50 nM or less.Fórmula:C17H13ClN4OForma y color:SolidPeso molecular:324.764MAT2A-IN-16
CAS:MAT2A-IN-16 is a MAT2A inhibitor that effectively suppresses the proliferation of MTAP-/-HCT-116 cells, with an IC50 value of 20 nM.Fórmula:C23H17ClN6OForma y color:SolidPeso molecular:428.874EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Fórmula:C19H19FN8OForma y color:SolidPeso molecular:394.41MDH1/2-IN-1
CAS:MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.Fórmula:C25H33NO4Forma y color:SolidPeso molecular:411.534JTZ-951 HCl
CAS:JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).Fórmula:C17H17ClN4O4Pureza:98%Forma y color:SolidPeso molecular:376.79AR/BET protein degrader-1
CAS:AR/BET protein degrader-1 (Compound 149) is a dual-targeting protein degrader of Androgen Receptor and BET (bromodomain and extra-terminal domain), suitable for cancer research.Fórmula:C43H44N6O5Peso molecular:724.85MAT2A-IN-19
CAS:MAT2A-IN-19 (Compound I-3) is an inhibitor of methionine adenosyltransferase 2A (MAT2A), with an IC50 of 32.93 nM.
Fórmula:C23H15F5N6O3Forma y color:SolidPeso molecular:518.396LSD1/2-IN-3
LSD1/2-IN-3 selectively inhibits LSD1 (Ki 11 nM) over LSD2 (Ki 7 μM), and hinders tumor stem cell proliferation.Fórmula:C9H8BrF2NForma y color:SolidPeso molecular:248.07MC2652
MC2652, a potent LSD1 inhibitor, suppresses leukemia (MV4-11, NB4) and impedes prostate cancer (LNCaP) cell growth.Fórmula:C22H20N2OForma y color:SolidPeso molecular:328.41Basroparib
CAS:Basroparib is an inhibitor of ribose polymerase (PARP) and has shown antitumour effects.Fórmula:C18H21F2N7O3Forma y color:SolidPeso molecular:421.4SGC6870N
CAS:SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.Fórmula:C23H21BrN2O2SPeso molecular:469.39AZ13824374
AZ13824374: potent, selective ATAD2 inhibitor; anti-proliferative in breast cancer; pIC50: FRET 8.2, NanoBRET 6.2.Fórmula:C30H39FN8O2Forma y color:SolidPeso molecular:562.68
