Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2553 productos de "Cromatina / Epigenética"
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WIZ degrader 8
CAS:WIZ degrader 8 (compound 10) is a potent and selective molecular glue degrader of the transcription factor WIZ, effectively inducing HbF expression. It promotes WIZ degradation and HbF induction, suggesting its potential use as an inhibitor for sickle cell disease.Fórmula:C21H27N3O4Forma y color:SolidPeso molecular:385.457PARP-1/HDAC-IN-1
CAS:PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.Fórmula:C22H18N4O4Pureza:95.94%Forma y color:SolidPeso molecular:402.4WW437
WW437 is a histone deacetylase (HDAC) inhibitor that exhibits potent anti-breast cancer activity both in vitro and in vivo.Fórmula:C23H27N5O4Forma y color:SolidPeso molecular:437.49(rac)-Talazoparib
CAS:(rac)-Talazoparib ((rac)-BMN-673) (Compound 47) is an orally active inhibitor of PARP1/2, with Ki values of 1.2 nM and 0.87 nM, respectively. It inhibits cellular PARylation at an EC50 of 2.51 nM. This compound leads to the accumulation of DNA damage and suppresses the proliferation of BRCA1/2-mutated MX-1 and Capan-1 cells, with IC50 values of 0.3 nM and 5 nM, respectively. Additionally, (rac)-Talazoparib exhibits antitumor activity in mouse models.Fórmula:C19H14F2N6OForma y color:SolidPeso molecular:380.351BRD-7880
CAS:BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.Fórmula:C32H38N4O7Forma y color:SolidPeso molecular:590.67lirucitinib
CAS:Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.Fórmula:C16H25N5OSForma y color:SolidPeso molecular:335.468RK-0080552
CAS:RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.Fórmula:C12H6N6O2Forma y color:SolidPeso molecular:266.215OM-153
CAS:OM-153 blocks tankyrase 1 (IC50: 13 nM) and 2 (IC50: 2 nM), stifling WNT signaling and COLO 320DM cell growth.Fórmula:C28H24FN7O2Forma y color:SolidPeso molecular:509.53AZ-3
CAS:AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).Fórmula:C20H28FN7Pureza:98%Forma y color:SolidPeso molecular:385.48GDC-9918
CAS:GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Fórmula:C20H18F2N6O5SForma y color:SolidPeso molecular:492.46SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Fórmula:C20H26N8OSPureza:98%Forma y color:SolidPeso molecular:426.54MMSET-IN-1
CAS:MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .Fórmula:C18H29N7O5Pureza:98%Forma y color:SolidPeso molecular:423.47Glycyl H-1152 hydrochloride
CAS:Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Fórmula:C18H26Cl2N4O3SForma y color:SolidPeso molecular:449.39MI-1481
CAS:MI-1481: potent MML1 inhibitor, IC50 3.6 nM; disrupts menin-MLL1, active in MLL leukemia.Fórmula:C29H30F3N7O2SPureza:98%Forma y color:SolidPeso molecular:597.65GNE-886
CAS:GNE-886 has a wide range of applications in life science related research.Fórmula:C28H30N6O3Pureza:98%Forma y color:SolidPeso molecular:498.59PF-06726304 acetate
CAS:PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.Fórmula:C24H25Cl2N3O5Pureza:98%Forma y color:SolidPeso molecular:506.38FT001
CAS:FT001: Oral BET Bromodomain inhibitor, IC50=0.46μM, suppresses MYC, anti-cancer, effective in vitro/vivo.Fórmula:C25H29N3O4SPureza:99.9%Forma y color:SolidPeso molecular:467.58Ref: TM-T27392
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.147,00€1mL*10mM (DMSO)299,00€(Rac)-Nanatinostat
CAS:(Rac)-Nanatinostat ((Rac)-CHR-3996, example 44) is a potent HDAC inhibitor with an IC50 of less than 330 nM. It exhibits anticancer properties, effectively inhibiting the growth of HeLa, U937, and HUT cells.Fórmula:C20H19FN6O2Forma y color:SolidPeso molecular:394.402BRD4 Inhibitor-32
CAS:BRD4 Inhibitor-32 (example 15), a BRD4 inhibitor, is applicable in research pertaining to both acute and chronic kidney disease [1].Fórmula:C26H25N3O3Forma y color:SolidPeso molecular:427.5PAD-IN-2
CAS:PAD-IN-2, potent PAD4 inhibitor, IC50 <1 μM; targets autoimmune/cancer disorders.Fórmula:C27H28ClN5O2Forma y color:SolidPeso molecular:490
