Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2440 productos de "Cromatina / Epigenética"
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BRD4-IN-7
CAS:BRD4-IN-7, also known as compound 120, acts as a BRD4 inhibitor.Fórmula:C29H24F2N4O3Forma y color:SolidPeso molecular:514.52Zavondemstat L-lysine
CAS:Zavondemstat (L-lysine) (QC8222; TACH 101) is an inhibitor of the histone lysine demethylase 4D (KDM4D) with antitumor properties.Fórmula:C32H43N5O5Peso molecular:577.71M-525
CAS:M-525, a potent first-in-class menin-MLL inhibitor, binds at 3 nM IC50 and curbs MLL leukemia cell growth & gene expression.Fórmula:C39H51FN6O5SPureza:98%Forma y color:SolidPeso molecular:734.92FT001
CAS:FT001: Oral BET Bromodomain inhibitor, IC50=0.46μM, suppresses MYC, anti-cancer, effective in vitro/vivo.Fórmula:C25H29N3O4SPureza:99.9%Forma y color:SolidPeso molecular:467.58Ref: TM-T27392
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.147,00€1mL*10mM (DMSO)299,00€DS44470011
CAS:DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.Fórmula:C21H19N3O4Forma y color:SolidPeso molecular:377.39Glycyl H-1152 hydrochloride
CAS:Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Fórmula:C18H26Cl2N4O3SForma y color:SolidPeso molecular:449.39YLIU-4-105-1
CAS:YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Fórmula:C32H34F3N7O2Forma y color:SolidPeso molecular:605.65TAF1 ligand 1
CAS:TAF1 ligand 1 is a TAF1 ligand. It can serve as a ligand for target proteins (Ligands for Target Protein for PROTAC) in the synthesis of PROTACs targeting TAF1, such as ZS3-046.Fórmula:C23H23N5O3Forma y color:SolidPeso molecular:417.46PFI-6-COOH
CAS:PFI-6-COOH (Compound 18) is a ligand for the eleven-nineteen leukemia (ENL) protein, and is utilized in the synthesis of the ENL PROTAC degrader MS41.Fórmula:C23H21N3O6Forma y color:SolidPeso molecular:435.43BRD4 D1-IN-2
BRD4 D1-IN-2 (compound 26), a BRD4 D1 inhibitor, IC50 <0.092 μM, 15 nM affinity, >500x selectivity over BRD2 D1/BRD4 D2.Fórmula:C33H39F3N6OForma y color:SolidPeso molecular:592.7Basroparib
CAS:Basroparib is an inhibitor of ribose polymerase (PARP) and has shown antitumour effects.Fórmula:C18H21F2N7O3Forma y color:SolidPeso molecular:421.4GSK852
GSK852 is a potent, second bromodomain (BD2)-selective, bromo and extra-terminal domain (BET) inhibitor with pIC50 of 7.9.Fórmula:C24H26N2O4Forma y color:SolidPeso molecular:406.47HLCL-61
CAS:HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).Fórmula:C23H24N2OForma y color:SolidPeso molecular:344.45Trichostatin A S-isomer
CAS:Trichostatin A S-isomer, a HDAC 1, 3, 4, 6, 10 inhibitor with IC50 ~20 nM, has wide-ranging epigenetic effects.Fórmula:C17H22N2O3Pureza:98%Forma y color:SolidPeso molecular:302.37MAT2A-IN-17
CAS:<p>MAT2A-IN-17 is a potent inhibitor of MAT2A, with an IC50 of less than 100 nM. MAT2A-IN-17 is applicable in cancer research.</p>Fórmula:C23H18F3N7OForma y color:SolidPeso molecular:465.431cis-4-Br-2,5-F2-PCPA
cis-4-Br-2,5-F2-PCPA (S1024) blocks LSD1/LSD2 (Ki: 94 nM/8.4 μM), hinders cancer stem cell growth, raises H3K4me2 in CCRF-CEM cells.Fórmula:C9H8BrF2NForma y color:SolidPeso molecular:248.075-AIQ hydrochloride
CAS:5-AIQ hydrochloride is a water-soluble PARP-1 inhibitor and serves as a vital functional group in various medications. It mitigates tissue damage associated with hepatic ischemia-reperfusion, making it valuable for research into conditions related to liver ischemia-reperfusion.Fórmula:C9H9ClN2OForma y color:SolidPeso molecular:196.634PARP14 inhibitor 1
CAS:<p>PARP14 inhibitor1 (compound Q22) is a selective inhibitor of PARP14 with an IC50 of 5.52 nM. It also exhibits anti-inflammatory properties and has a half-life of 182 minutes in mouse liver microsomes. This compound is applicable for atopic dermatitis research.</p>Fórmula:C23H27FN4O3Forma y color:SolidPeso molecular:426.484IBL-302
CAS:IBL-302 (AMU302), an orally available dual-signaling inhibitor targeting PIM and PI3K/AKT/mTOR, is effective against breast cancer and neuroblastoma. It has shown in vivo efficacy in a nude mouse xenograft model by combating trastuzumab resistance. Additionally, IBL-302 augments the effectiveness of widely used cytotoxic chemotherapy drugs such as cisplatin, doxorubicin, and etoposide [1] [2] [3].Fórmula:C25H18FN5O4S3Forma y color:SolidPeso molecular:567.64PRMT5-IN-1 hydrochloride
PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.Fórmula:C19H20Cl2N4O5Forma y color:SolidPeso molecular:455.29
