Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2440 productos de "Cromatina / Epigenética"
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AJI-100
CAS:AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Fórmula:C17H14FN5OForma y color:SolidPeso molecular:323.32SE-7552
CAS:<p>SE-7552, a derivative of 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO), serves as an orally active, highly selective non-hydroxamate HDAC6 inhibitor, boasting an IC50 of 33 nM. It exhibits over 850-fold selectivity against all other known HDAC isozymes. Demonstrating efficacy in vivo, SE-7552 effectively inhibits the growth of multiple myeloma. Additionally, it functions as an anti-obesity agent in diet-induced obese mice [1] [2].</p>Fórmula:C15H12F3N5OForma y color:SolidPeso molecular:335.28SMARCA2-IN-2
CAS:Compound I-25, also known as SMARCA2-IN-2, is a SMARCA2 inhibitor (IC 50: 101-500 μM) with applications in cancer research.Fórmula:C16H17N3Forma y color:SolidPeso molecular:251.33CP-352664
CAS:CP-352664 is a JAK inhibitor with potency against JAK3, exhibiting an EC50 value of 210 nM. It holds potential for use in research related to organ transplant rejection and autoimmune diseases, such as rheumatoid arthritis.Fórmula:C18H18N4Forma y color:SolidPeso molecular:290.36MAT2A-IN-20
CAS:<p>MAT2A-IN-20 (Compound A49) is an inhibitor of methionine adenosyltransferase 2A (MAT2A) with an IC50 of ≤50 nM. It also inhibits human UGT1A1 with an IC50 of 28.45 μM. Additionally, MAT2A-IN-20 exhibits antitumor activity in mouse models.</p>Fórmula:C26H24F2N6O4Forma y color:SolidPeso molecular:522.503CRV431
CAS:CRV431 is a novel Pan-Cyclophilin Inhibitor, potently inhibiting all cyclophilin isoforms tested - A, B, D, and G (IC50 values ranged from 1-7 nM).Fórmula:C67H122N12O13Forma y color:SolidPeso molecular:1303.76Bromodomain inhibitor-13
CAS:Bromodomain Inhibitor-13 (Compound 1), an analog of PFI-3, is a bromodomain-containing protein (BCP) inhibitor. It specifically targets the bromodomains of SMARCA2, SMARCA4, and the first and second bromodomains of PB1 [PB1(5) and PB1(2)], with dissociation constants (KD) of 37, 53, 30, and 190 nM, respectively.Fórmula:C21H22N4O2Forma y color:SolidPeso molecular:362.43AMI-408
CAS:AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.Fórmula:C20H13Cl2N6NaO5SForma y color:SolidPeso molecular:543.32RK-0080552
CAS:RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.Fórmula:C12H6N6O2Forma y color:SolidPeso molecular:266.215MAT2A-IN-21
CAS:<p>MAT2A-IN-21 (compound 28) is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A), with an IC50 of 49 nM. It selectively inhibits cancer cells with MTAP deficiency.</p>Fórmula:C26H20F2N4O2Forma y color:SolidPeso molecular:458.459GDC-0339
CAS:GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.Fórmula:C20H22F3N7OSForma y color:SolidPeso molecular:465.5YTH-IN-1
CAS:YTH-IN-1 is an inhibitor of the five YTH structural domains in the human.The YTH family of proteins is an N 6-methyladenosine (m6A) reader in gene expression.Fórmula:C18H24N6O3Pureza:98.46% - 99.94%Forma y color:SolidPeso molecular:372.42BAY-3827
CAS:BAY-3827 is an AMPK inhibitor with antiproliferative activity and antitumor activity. BAY-3827 inhibits the phosphorylation of acetyl CoA carboxylase 1.Fórmula:C27H25FN6OPureza:99.90%Forma y color:SolidPeso molecular:468.53Ref: TM-T73350
1mg56,00€5mg119,00€10mg187,00€25mg354,00€50mg590,00€100mg835,00€500mg1.663,00€1mL*10mM (DMSO)124,00€EZM0414
CAS:EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.Fórmula:C22H29FN4O2Pureza:99.58%Forma y color:SolidPeso molecular:400.49Aldometanib
CAS:Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.Fórmula:C27H43Cl2IN2Pureza:99.32% - 99.55%Forma y color:SolidPeso molecular:593.46Ref: TM-T60122
1mg44,00€5mg90,00€10mg130,00€25mg274,00€50mg405,00€100mg600,00€200mg837,00€1mL*10mM (DMSO)111,00€DN02
<p>DN02: a potent, selective BRD8(1) bromodomain probe; Ki=32 nM; 30x more affine than BRD8(2).</p>Fórmula:C22H24FN3O3Pureza:98.22% - 99.74%Forma y color:SolidPeso molecular:397.44AMG-193
CAS:AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.Fórmula:C22H19F3N4O3Pureza:99.52%Forma y color:SolidPeso molecular:444.41Ref: TM-T85645
1mg49,00€5mg104,00€10mg169,00€25mg329,00€50mg533,00€100mg848,00€1mL*10mM (DMSO)115,00€Pocenbrodib
CAS:<p>Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research.</p>Fórmula:C28H32FN3O6Pureza:98.48% - 99.54%Forma y color:SolidPeso molecular:525.57ORIC-944
CAS:ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.Fórmula:C26H25FN6OPureza:98.08%Forma y color:SolidPeso molecular:456.52INCB054329
CAS:INCB054329 is a BET inhibitor targeting BRD2/3/4 and BRDT with IC50s ranging from 1-119 nM.Fórmula:C19H16N4O3Pureza:99.52%Forma y color:SolidPeso molecular:348.36
