Daño al ADN / Reparación del ADN
Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.
Subcategorías de "Daño al ADN / Reparación del ADN"
- ATM / ATR(71 productos)
- Alquilación de ADN(11 productos)
- ADN metiltransferasa(422 productos)
- ADN girasa(11 productos)
- ADN-PK(50 productos)
- MTH1(1 productos)
- Antimetabolito / análogo nucleósido(1.388 productos)
- Transcriptasa inversa(43 productos)
- Sirtuin(88 productos)
- Telomerasa(33 productos)
- Topoisomerasa(136 productos)
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Se han encontrado 962 productos de "Daño al ADN / Reparación del ADN"
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HDAC8-IN-4
CAS:<p>HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].</p>Fórmula:C17H14N2O2S2Pureza:98%Forma y color:SolidPeso molecular:342.44CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Fórmula:C29H43Cl3N4O3Pureza:98%Forma y color:SolidPeso molecular:602.04U-46619
CAS:U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (Fórmula:C21H34O4Pureza:98%Forma y color:SolidPeso molecular:350.49Bocodepsin hydrochloride
CAS:<p>Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration.</p>Fórmula:C26H40ClN5O6S2Pureza:98%Forma y color:SolidPeso molecular:618.21CM-675
CAS:<p>CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to</p>Fórmula:C31H32N6O3Pureza:99.82%Forma y color:SolidPeso molecular:536.62DNMT-IN-3
CAS:<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Fórmula:C37H39N7OForma y color:SolidPeso molecular:597.75ATR-IN-5
CAS:<p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>Fórmula:C27H32F3N9OForma y color:SolidPeso molecular:555.6ATR-IN-22
CAS:<p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>Fórmula:C25H31N7OPureza:98%Forma y color:SolidPeso molecular:445.56HDAC/BET-IN-1
CAS:<p>HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.</p>Fórmula:C29H40N4O8SPureza:98%Forma y color:SolidPeso molecular:604.71SRT3657
CAS:<p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>Fórmula:C40H54N8O6SPureza:98%Forma y color:SolidPeso molecular:774.97HDAC6-IN-8
CAS:<p>Compound 12C, with altered cap groups, shows wide-range enzyme inhibition; 9m and 9q target HDAC6 specifically.</p>Fórmula:C23H17BrFN5O3Pureza:98%Forma y color:SolidPeso molecular:510.32Topoisomerase inhibitor 2
CAS:<p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>Fórmula:C23H23N5O4Pureza:98%Forma y color:SolidPeso molecular:433.46BMS-250749
CAS:<p>BMS-250749 is a fluoroglycosylated fluoroindolocarbazole, it has antitumor activity.</p>Fórmula:C26H18F3N3O6Pureza:98%Forma y color:SolidPeso molecular:525.43Trovafloxacin mesylate
CAS:<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Fórmula:C21H19F3N4O6SPureza:99.18%Forma y color:SolidPeso molecular:512.46Topoisomerase I inhibitor 9
CAS:<p>Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value</p>Fórmula:C23H15Br2FN2Pureza:98%Forma y color:SolidPeso molecular:498.19KD-3010
CAS:<p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>Fórmula:C30H33F3N2O8S2Pureza:99.61%Forma y color:SolidPeso molecular:670.72Pradofloxacin
CAS:<p>Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.</p>Fórmula:C21H21FN4O3Pureza:98.76%Forma y color:SolidPeso molecular:396.41MPI_5a
CAS:<p>MPI_5a selectively inhibits HDAC6 (IC50=36 nM), slightly affects other HDACs, and blocks acyl-tubulin build-up (IC50=210 nM).</p>Fórmula:C16H17N3O3Pureza:99.62%Forma y color:SolidPeso molecular:299.32DY-46-2
CAS:<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Fórmula:C19H22N6O5SPureza:99.12% - 99.12%Forma y color:SolidPeso molecular:446.48SDOX
CAS:<p>SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.</p>Fórmula:C69H97NO20S2Pureza:98%Forma y color:SolidPeso molecular:1324.63Antipsychotic agent 54
CAS:Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM).Fórmula:C21H23FN2O4Pureza:98.10%Forma y color:SolidPeso molecular:386.42NT160
CAS:<p>NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.</p>Fórmula:C21H21F3N4O2Pureza:99.3%Forma y color:SolidPeso molecular:418.41Topoisomerase IIα-IN-8
CAS:<p>Topoisomerase IIα-IN-8 (compound 15) serves as a modest inhibitor of human DNA topoisomerase IIα (htIIα), exhibiting an inhibitory concentration (IC50) of 462 ± 38.0 μM [1].</p>Fórmula:C15H15FN6OForma y color:SolidPeso molecular:314.324Bocodepsin
CAS:<p>Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy.</p>Fórmula:C26H39N5O6S2Pureza:98%Forma y color:SolidPeso molecular:581.75NH2-methylpropanamide-Exatecan TFA
CAS:<p>Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.</p>Fórmula:C30H30F4N4O7Pureza:98%Forma y color:SolidPeso molecular:634.58Furegrelate sodium
CAS:<p>Furegrelate sodium (U-63557A) is an orally active thromboxane synthase inhibitor with an IC50 of 15 nM in platelets.</p>Fórmula:C15H10NNaO3Pureza:99.92%Forma y color:SolidPeso molecular:275.23Zabofloxacin
CAS:Zabofloxacin inhibits bacterial topoisomerases II/IV, effectively targeting gram-positive pathogens like S. aureus and S. pneumoniae.Fórmula:C19H20FN5O4Pureza:98%Forma y color:SolidPeso molecular:401.39HDAC6-IN-21
CAS:<p>HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].</p>Fórmula:C14H13F2N5O2Pureza:98%Forma y color:SolidPeso molecular:321.2810-Nitrolinoleic acid
CAS:<p>10-Nitrolinoleate, a nitration product of linoleate, modulates PPARγ, enhancing glucose uptake, and aids in muscle relaxation via NO/cGMP pathway.</p>Fórmula:C18H31NO4Forma y color:SolidPeso molecular:325.447-Deaza-2′-deoxyguanosine 5′-triphosphate
CAS:<p>7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].</p>Fórmula:C11H17N4O13P3Pureza:98%Forma y color:SolidPeso molecular:506.19ATR-IN-29
CAS:<p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>Fórmula:C19H22N8OPureza:98%Forma y color:SolidPeso molecular:378.43ATR-IN-6
CAS:<p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>Fórmula:C28H28FN7O2Forma y color:SolidPeso molecular:513.57ATR-IN-8
CAS:<p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>Fórmula:C20H22N6O2SForma y color:SolidPeso molecular:410.49PARP7-IN-15
CAS:<p>PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].</p>Fórmula:C23H24F6N6O4Pureza:98%Forma y color:SolidPeso molecular:562.46SIRT6-IN-3
CAS:<p>SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts</p>Fórmula:C21H30Br3ClN6SPureza:98%Forma y color:SolidPeso molecular:673.73Oxamflatin
CAS:Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).Fórmula:C17H14N2O4SPureza:98.25%Forma y color:SolidPeso molecular:342.37Tankyrase-IN-5
CAS:<p>Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitory</p>Fórmula:C17H18N2O2Pureza:98%Forma y color:SolidPeso molecular:282.34PARP7-IN-16
CAS:<p>PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.</p>Fórmula:C25H26FN4NaO4Pureza:98%Forma y color:SolidPeso molecular:488.49Lexitropsin 1
CAS:<p>Lexitropsin 1 is a new anticancer drug.</p>Fórmula:C15H19N7O3SPureza:98%Forma y color:SolidPeso molecular:377.42Ambamustine
CAS:<p>Ambamustine (PTT 119): a tripeptide nitrogen mustard, DNA inhibitor/alkylator with antitumor properties, researched for various disorders.</p>Fórmula:C29H39Cl2FN4O4SPureza:98%Forma y color:SolidPeso molecular:629.61(S)-Ceralasertib
CAS:<p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>Fórmula:C20H24N6O2SForma y color:SolidPeso molecular:412.51Nesuparib
CAS:<p>Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.</p>Fórmula:C23H24N6OPureza:99.71%Forma y color:SolidPeso molecular:400.48BM152054
CAS:<p>BM152054 is a potent PPARγ ligand that induces glucose utilization in peripheral tissues by enhancing insulin action.</p>Fórmula:C22H18N2O4S3Pureza:99.56%Forma y color:SolidPeso molecular:470.58KPZ560
CAS:<p>KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.</p>Fórmula:C26H21N5O3S2Pureza:98%Forma y color:SolidPeso molecular:515.61WAY-354574
CAS:<p>WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].</p>Fórmula:C20H23ClN2O3SPureza:98%Forma y color:SolidPeso molecular:406.93ATR-IN-18
CAS:<p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>Fórmula:C19H22F3N7O5SForma y color:SolidPeso molecular:517.48ATM-IN-1
CAS:<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Fórmula:C30H36N6O3Forma y color:SolidPeso molecular:528.65E7016
CAS:<p>E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.</p>Fórmula:C20H19N3O3Pureza:99.02%Forma y color:SolidPeso molecular:349.38Ragaglitazar
CAS:<p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>Fórmula:C25H25NO5Pureza:97.46% - 98.56%Forma y color:SolidPeso molecular:419.47PARP-1-IN-4
CAS:<p>PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.</p>Fórmula:C22H15Cl2N3O2Pureza:99.82%Forma y color:SolidPeso molecular:424.28Lartesertib
CAS:<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Fórmula:C23H21FN6O3Pureza:99.9%Forma y color:SolidPeso molecular:448.45AZ31
CAS:<p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,</p>Fórmula:C24H28N4O3Pureza:98.01%Forma y color:SolidPeso molecular:420.5Camonsertib
CAS:<p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>Fórmula:C21H26N6O3Pureza:99.6% - 99.93%Forma y color:SolidPeso molecular:410.47IACS-52825
CAS:<p>IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.</p>Fórmula:C16H13F7N4O2Pureza:99.77%Forma y color:SolidPeso molecular:426.29CGS 15435
CAS:<p>CGS 15435: potent TxA2 synthase inhibitor, IC50=1 nM; less selective for PGI2 synthase, COX, and liposynthase.</p>Fórmula:C20H21ClN2O2Pureza:99.86%Forma y color:SolidPeso molecular:356.85Retelliptine
CAS:Retelliptine, a DNA topoisomerase II inhibitor, is used potentially for the treatment of cancer.Fórmula:C25H32N4OPureza:98%Forma y color:SolidPeso molecular:404.55PPARγ agonist 1
<p>PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.</p>Fórmula:C34H39NO3Forma y color:SolidPeso molecular:509.68LP-284
CAS:<p>LP-284 is a DNA alkylating agent effective against solid tumors and hematologic cancers like MCL.</p>Fórmula:C16H20N2O4Forma y color:SolidPeso molecular:304.34PPARα agonist 1
<p>PPARα agonist 1 is a complete and potent PPARα agonist.</p>Fórmula:C27H34O4Forma y color:SolidPeso molecular:422.56G-631
CAS:<p>G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.</p>Fórmula:C19H22F2N6O3Forma y color:SolidPeso molecular:420.41(Rac)-RG108
CAS:<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Fórmula:C19H14N2O4Forma y color:SolidPeso molecular:334.326TMU 35435
CAS:<p>TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).</p>Fórmula:C22H25N3O3Forma y color:SolidPeso molecular:379.45Topoisomerase inhibitor 5
CAS:<p>Topoisomerase inhibitor 5 (compound 158) is an inhibitor of bacterial topoisomerase, with a minimum inhibitory concentration of 0.125 μg/mL, and exhibits anti-tuberculosis activity.</p>Fórmula:C24H25FN4O6Forma y color:SolidPeso molecular:484.477ATR kinase-IN-3
CAS:<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Fórmula:C24H27F2N9O2Forma y color:SolidPeso molecular:511.53SIRT6 activator 2
CAS:<p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>Fórmula:C23H23N3O6Forma y color:SolidPeso molecular:437.45PARP1/2-IN-4
CAS:<p>PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.</p>Fórmula:C23H30FN5O6Forma y color:SolidPeso molecular:491.51ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54Topoisomerase I inhibitor 8
CAS:<p>Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.</p>Fórmula:C24H21FN2O4Forma y color:SolidPeso molecular:420.43PPARα/δ agonist 3
CAS:<p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>Fórmula:C23H25F3N2O4Forma y color:SolidPeso molecular:450.451PPARγ-IN-5
CAS:<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Fórmula:C22H23ClO7Forma y color:SolidPeso molecular:434.867O6BTG-C8-αGlu
CAS:<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Fórmula:C24H34BrN5O7SForma y color:SolidPeso molecular:616.525RU-0415529
CAS:<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Fórmula:C21H29N3O4SForma y color:SolidPeso molecular:419.538Sirtuin-IN-2
<p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>Fórmula:C28H46N8O6SForma y color:SolidPeso molecular:622.78ATR-IN-12
<p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>Fórmula:C22H27N5O3SForma y color:SolidPeso molecular:441.55ATR-IN-19
CAS:<p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>Fórmula:C18H19N7OSForma y color:SolidPeso molecular:381.45Amezalpat
CAS:<p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>Fórmula:C34H41N3O4Forma y color:SolidPeso molecular:555.707Bizelesin
CAS:<p>Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.</p>Fórmula:C43H36Cl2N8O5Forma y color:SolidPeso molecular:815.7(1R,2S,7R)-Sitafloxacin
CAS:<p>(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.</p>Fórmula:C19H18ClF2N3O3Forma y color:SolidPeso molecular:409.814(S)-WSD0628
CAS:<p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.458ATR kinase-IN-2
CAS:<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Fórmula:C24H29F2N9O2Forma y color:SolidPeso molecular:513.54(1S,2R,7S)-Sitafloxacin
CAS:<p>(1S,2R,7S)-Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin and functions as a topoisomerase inhibitor. As an antibiotic, it demonstrates inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S)-Sitafloxacin exhibits antibacterial properties and is utilized in the study of various bacterial infections.</p>Fórmula:C19H18ClF2N3O3Forma y color:SolidPeso molecular:409.81ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Fórmula:C26H31N7O3Forma y color:SolidPeso molecular:489.57PPARγ modulator-2
CAS:<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Fórmula:C26H21NO7S3SeForma y color:SolidPeso molecular:634.6TH1338
CAS:<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Fórmula:C22H21N3O4Pureza:98.77%Forma y color:SolidPeso molecular:391.42Camptothecin-20(S)-O-propionate
CAS:<p>CZ-48 is a DNA topoisomerase inhibitor.</p>Fórmula:C23H20N2O5Forma y color:SolidPeso molecular:404.42TERT activator-2
CAS:<p>TERT activator-2 (Compound 1030) is an activator of telomerase reverse transcriptase (TERT), which enhances the expression levels of TERT within cells. TERT activator-2 is applicable to research related to cellular lifespan and telomere functions.</p>Fórmula:C21H22N2O2Forma y color:SolidPeso molecular:334.412DNA crosslinker 1 dihydrochloride
CAS:<p>DNA Crosslinker 1 binds DNA minor groove with 1.1°C affinity increase; used in cancer research.</p>Fórmula:C15H22Cl2N8OForma y color:SolidPeso molecular:401.29Antibacterial agent 236
CAS:<p>Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.</p>Fórmula:C26H27N5O2SForma y color:SolidPeso molecular:473.59Atiratecan
CAS:<p>Atiratecan (TP300), a CH0793076-based camptothecin prodrug, combats BCRP+/- tumors; doesn't affect AChE.</p>Fórmula:C31H34N6O6Pureza:98%Forma y color:SolidPeso molecular:586.64DNA crosslinker 3 dihydrochloride
CAS:<p>Compound 1: a DNA minor groove binder with 1.4°C ΔTm; useful in cancer research.</p>Fórmula:C15H22Cl2N8OForma y color:SolidPeso molecular:401.29Pparδ agonist 5
<p>Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.</p>Fórmula:C23H21F3N2O2SForma y color:SolidPeso molecular:446.49DNA-PK-IN-2
CAS:<p>DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.</p>Fórmula:C20H23N5O3Forma y color:SolidPeso molecular:381.43DNA-PK-IN-15
CAS:DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.Fórmula:C23H23N9OForma y color:SolidPeso molecular:441.49HDAC6-IN-51
CAS:HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.Fórmula:C24H24ClN5O3Forma y color:SolidPeso molecular:465.93Cas9-IN-1
<p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>Fórmula:C17H11Cl2F3N2O3SForma y color:SolidPeso molecular:451.25DNA crosslinker 2 dihydrochloride
CAS:<p>Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.</p>Fórmula:C15H22Cl2N8OForma y color:SolidPeso molecular:401.29TDI-015051
CAS:<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Fórmula:C22H22FN5O4SForma y color:SolidPeso molecular:471.505ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Fórmula:C25H29FN6O3Forma y color:SolidPeso molecular:480.53DLK-IN-1
CAS:DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Fórmula:C20H24F3N5O2Forma y color:SolidPeso molecular:423.43PARP1-IN-30
CAS:<p>PARP1-IN-30 is a specific and effective PARP1 inhibitor with cytotoxic properties. It precisely inhibits PARP1 in tumor cells lacking breast cancer 1 protein (BRCA1) or BRCA2. PARP1-IN-30 holds potential for use in cancer research.</p>Fórmula:C14H12ClNO4SForma y color:SolidPeso molecular:325.77L2H2-6OTD
CAS:<p>L2H2-6OTD is a telomerase inhibitor with G-quadruplex loops; IC50: 15 nM.</p>Fórmula:C30H30N10O8Forma y color:SolidPeso molecular:658.62DNA crosslinker 4 dihydrochloride
CAS:<p>DNA Crosslinker 4 binds DNA's minor groove, inhibits NCI-H460, A2780, MCF-7 cancer cells, and is used in cancer research.</p>Fórmula:C16H24Cl2N8OForma y color:SolidPeso molecular:415.3215-keto-Prostaglandin E2
CAS:<p>15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression.</p>Fórmula:C20H30O5Pureza:98%Forma y color:SolidPeso molecular:350.45ATM Inhibitor-11
CAS:<p>ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.</p>Fórmula:C27H33FN6O2Forma y color:SolidPeso molecular:492.592-Ethylhexyl diphenyl phosphate
CAS:<p>2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.</p>Fórmula:C20H27O4PForma y color:SolidPeso molecular:362.40SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Fórmula:C20H20N6O5SForma y color:SolidPeso molecular:456.48PPARγ phosphorylation inhibitor 1
PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binding agent (IC50: 24 nM) with antidiabetic effects.Fórmula:C22H14Cl2N2O4Forma y color:SolidPeso molecular:441.26Topoisomerase II inhibitor 6
<p>Topoisomerase II inhibitor 6, a potent tryptanthrin derivative, blocks G2 phase in CCRF-CEM cells, induces DNA breaks, and may be used for cancer research.</p>Fórmula:C19H18N4O2Forma y color:SolidPeso molecular:334.37Topoisomerase I/II inhibitor 7
CAS:<p>Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.</p>Fórmula:C18H13ClN2O3Forma y color:SolidPeso molecular:340.76Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Fórmula:C21H24N4OPureza:98%Forma y color:SolidPeso molecular:348.44KSQ-4279 (gentisate)
CAS:<p>KSQ-4279 (gentisate) (Compound Formula I) serves as an effective inhibitor of USP1 and a selective inhibitor of PARP1. This compound shows promise for use in cancer research.</p>Fórmula:C34H31F3N8O5Forma y color:SolidPeso molecular:688.66Topoisomerase I/II inhibitor 2
<p>Compound 1a inhibits Topoisomerase I/II, shrinks mouse liver tumors, IC50: 6.83/9.82 μM for LM9/Huh7 cells.</p>Fórmula:C19H16N2O4Forma y color:SolidPeso molecular:336.34GSK1820795A
CAS:<p>GSK1820795A: Telmisartan analog, selective hGPR132a antagonist, blocks yeast activation by N-acylamides, angiotensin II antagonist, partial PPARγ agonist.</p>Fórmula:C35H34N8Forma y color:SolidPeso molecular:566.7Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Fórmula:C25H25N3O5Pureza:98.47%Forma y color:SolidPeso molecular:447.48DNA-PK-IN-8
CAS:<p>DNA-PK-IN-8: Potent, selective oral DNA-PK inhibitor, IC50 = 0.8 nM, boosts anti-cancer effects with Doxorubicin.</p>Fórmula:C19H22N8O2Forma y color:SolidPeso molecular:394.43Topotecan acetate
CAS:<p>Topotecan acetate is an inhibitor of topoisomerase.</p>Fórmula:C25H27N3O7Forma y color:SolidPeso molecular:481.498Topoisomerase II inhibitor 5
<p>Topoisomerase II inhibitor 5 (Compound E24) is a DNAtopoisomerase II inhibitor with anticancer effects.</p>Fórmula:C26H27N5O4Forma y color:SolidPeso molecular:473.52Namitecan
CAS:Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.Fórmula:C23H22N4O5Pureza:98%Forma y color:SolidPeso molecular:434.44Levofloxacin mesylate
CAS:<p>Levofloxacin mesylate is an orally active antibiotic effective against both Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase and topoisomerase IV enzymes. Levofloxacin mesylate is employed in research related to chronic periodontitis, airway inflammation, and BK viremia. Additionally, it possesses anti-Orthopoxvirus activity.</p>Fórmula:C19H24FN3O7SForma y color:SolidPeso molecular:457.473Lys(CO-C3-p-I-Ph)-O-tBu
CAS:<p>Lys(CO-C3-p-I-Ph)-O-tBu, a pharmacokinetic modifier (PK modifier), enhances the pharmacokinetic properties of PSMA ligand molecules by increasing their residence time in plasma through improved binding to albumin and reducing absorption by the salivary glands, potentially extending the active compound's half-life. Moreover, Ac-PSMA-trillium is an effective PSMA-targeting compound for various biological applications when modified with different radioactive isotopes. When labeled with 111 In, it serves as a DOTA chelating agent and imaging agent. Alternatively, when labeled with 225 Ac, it acts as a Macropa chelator for targeted radionuclide therapy (TRT) in researching metastatic castration-resistant prostate cancer (mCRPC) [1] [2].</p>Fórmula:C20H31IN2O3Forma y color:SolidPeso molecular:474.38Edotecarin
CAS:<p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>Fórmula:C29H28N4O11Pureza:98%Forma y color:SolidPeso molecular:608.55PPARα/γ agonist 1
<p>PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes.</p>Fórmula:C18H19NO2Forma y color:SolidPeso molecular:281.35HDAC8-IN-12
CAS:<p>HDAC8-IN-12 (compound 5k), a non-hydroxamic acid derivative, serves as a selective HDAC8 inhibitor with an IC 50 of 0.12 nM and demonstrates potent efficacy against breast cancer. This compound enhances anti-tumor immunity by activating T cells, elevating M1 macrophage levels, and reducing M2 macrophage proportions. In an orthotopic mouse model of breast cancer, HDAC8-IN-12, administered at 50 mg/kg, effectively suppresses tumor growth.</p>Fórmula:C16H17N3O5Forma y color:SolidPeso molecular:331.32ATM Inhibitor-4
<p>ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.</p>Fórmula:C26H29FN6O3Forma y color:SolidPeso molecular:492.55NU5455
CAS:<p>NU5455 is a potent DNA-PKcs inhibitor, oral, boosts doxorubicin in liver tumors, amplifies topoisomerase inhibitors, no adverse effects.</p>Fórmula:C34H33N3O5SForma y color:SolidPeso molecular:595.71OSUAB-0284
CAS:OSUAB-0284 is an inhibitor of bacterial topoisomerase. It exhibits significant activity against staphylococci, particularly methicillin-resistant Staphylococcus aureus (MRSA). The compound exerts its antibacterial effect by inhibiting bacterial topoisomerase and may be used in research on infections caused by drug-resistant bacteria, including MRSA.Fórmula:C22H23FN6O6Forma y color:SolidPeso molecular:486.45KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Fórmula:C29H32N4O4S2Pureza:99.10%Forma y color:SolidPeso molecular:564.72TP3011
CAS:<p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>Fórmula:C26H26N4O5Pureza:98%Forma y color:SolidPeso molecular:474.51ATR-IN-17
CAS:<p>ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).</p>Fórmula:C22H28N6O2SForma y color:SolidPeso molecular:440.56MC3138
CAS:<p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>Fórmula:C25H25NO6Pureza:99.57%Forma y color:SolidPeso molecular:435.47Karenitecin
CAS:<p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>Fórmula:C25H28N2O4SiPureza:98%Forma y color:SolidPeso molecular:448.59PARP-1/HDAC-IN-1
CAS:<p>PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.</p>Fórmula:C22H18N4O4Pureza:95.94%Forma y color:SolidPeso molecular:402.4WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.46PPARγ agonist 2
<p>PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ.</p>Fórmula:C24H20O5Forma y color:SolidPeso molecular:388.41Topoisomerase II inhibitor 18
CAS:<p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>Fórmula:C20H21N3OSForma y color:SolidPeso molecular:351.47PPARγ agonist 17
CAS:<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Fórmula:C48H63NO7Forma y color:SolidPeso molecular:766.016Anti-NASH agent 2
CAS:<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Fórmula:C32H51N3O2Forma y color:SolidPeso molecular:509.766SPR719
CAS:<p>SPR719 is an inhibitor of gyrase B, has bactericidal activity.</p>Fórmula:C21H25FN6O3Pureza:98%Forma y color:SolidPeso molecular:428.46Carbacyclin
CAS:<p>Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.</p>Fórmula:C21H34O4Pureza:98%Forma y color:SolidPeso molecular:350.49DNA-PK-IN-9
<p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>Fórmula:C21H21N5O2Forma y color:SolidPeso molecular:375.42SP-C01
CAS:<p>SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.</p>Fórmula:C22H22F4N2O5Forma y color:SolidPeso molecular:470.41ATR-IN-14
CAS:<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Fórmula:C20H20FN7OForma y color:SolidPeso molecular:393.42ATM Inhibitor-1
CAS:<p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>Fórmula:C27H36N6O3Pureza:98%Forma y color:SolidPeso molecular:492.61E-3030 free acid
CAS:<p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>Fórmula:C22H23ClFNO5Pureza:98%Forma y color:SolidPeso molecular:435.87DNA-PK-IN-6
CAS:<p>DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).</p>Fórmula:C19H21N7OForma y color:SolidPeso molecular:363.42KU-60019
CAS:<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Fórmula:C30H33N3O5SPureza:98.05% - 98.50%Forma y color:SolidPeso molecular:547.67Simmitecan hydrochloride
CAS:<p>Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.</p>Fórmula:C34H39ClN4O6Pureza:98.20% - 98.93%Forma y color:SolidPeso molecular:635.15BAY-8400
<p>BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in</p>Fórmula:C21H17F2N5OPureza:99.53%Forma y color:SolidPeso molecular:393.39OBI-3424
CAS:OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.Fórmula:C21H25N4O6PPureza:98%Forma y color:SolidPeso molecular:460.427YF438
CAS:<p>YF438 is an HDAC inhibitor that demonstrates potent anti-cancer activity both in vitro and in vivo. It inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2 from MDMX, and promoting the degradation of MDM2.</p>Fórmula:C23H26N4O5Forma y color:SolidPeso molecular:438.48Phenanthriplatin
CAS:<p>Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso</p>Fórmula:C13H11ClN4O3PtForma y color:SolidPeso molecular:501.79Zabofloxacin hydrochloride
CAS:<p>Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.</p>Fórmula:C19H21ClFN5O4Pureza:98%Forma y color:SolidPeso molecular:437.86NSC61610
CAS:<p>NSC61610 is anti-inflammatory that activates PPARγ in vitro via LANCL2 and adenylate cyclase/cAMP-dependent pathways, thereby improving experimental colitis.</p>Fórmula:C34H24N6O2Pureza:98%Forma y color:SolidPeso molecular:548.59Merbarone
CAS:<p>Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the n</p>Fórmula:C11H9N3O3SForma y color:SolidPeso molecular:263.27SR-4370
CAS:<p>SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp.</p>Fórmula:C17H18F2N2OPureza:99.50%Forma y color:SolidPeso molecular:304.33Fotemustine
CAS:<p>Fotemustine: antineoplastic, chloroethylates DNA, blocks synthesis, causes cell arrest/apoptosis, lipophilic, crosses blood-brain barrier.</p>Fórmula:C9H19ClN3O5PForma y color:SolidPeso molecular:315.69Mavodelpar free base
CAS:<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Fórmula:C31H30FNO5Pureza:98%Forma y color:SolidPeso molecular:515.57MDL-811
CAS:<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Fórmula:C25H25BrCl2FN3O5S2Pureza:98%Forma y color:SolidPeso molecular:681.42ATR-IN-24
CAS:<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Fórmula:C23H26N6O2Pureza:98%Forma y color:SolidPeso molecular:418.49Ref: TM-T79058
Producto descatalogadoAntitumor agent-104
CAS:<p>Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme</p>Fórmula:C31H33FN6O3Pureza:98%Forma y color:SolidPeso molecular:556.63Lerzeparib
CAS:<p>Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].</p>Fórmula:C21H20FN3O2Pureza:98%Forma y color:SolidPeso molecular:365.4PARP7-IN-16 free base
CAS:<p>PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.</p>Fórmula:C25H27FN4O4Forma y color:SolidPeso molecular:466.50Ref: TM-T200703
Producto descatalogado
