Topoisomerasa
Las topoisomerasas son enzimas que regulan la topología del ADN durante procesos como la replicación, transcripción y segregación de cromosomas, introduciendo rupturas transitorias en las hebras de ADN para aliviar el estrés torsional. Los inhibidores de topoisomerasa interfieren con este proceso, lo que lleva a la acumulación de rupturas en el ADN y la inducción de la muerte celular, particularmente en células que se dividen rápidamente. Estos inhibidores se utilizan ampliamente como agentes quimioterapéuticos en el tratamiento del cáncer. En CymitQuimica, ofrecemos una amplia gama de inhibidores de topoisomerasa de alta calidad para apoyar su investigación en replicación del ADN, terapia contra el cáncer y regulación del ciclo celular.
Se han encontrado 141 productos de "Topoisomerasa"
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Nalidixic acid sodium salt
CAS:<p>Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.</p>Fórmula:C12H11N2NaO3Pureza:99.72% - 99.95%Forma y color:White To Off-White PowderPeso molecular:254.22Daunorubicin hydrochloride
CAS:Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and proteinFórmula:C27H29NO10·HClPureza:96.21% - 99.53%Forma y color:Cancer DrugPeso molecular:563.99Lurtotecan
CAS:<p>Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.</p>Fórmula:C28H30N4O6Pureza:99.18%Forma y color:SoildPeso molecular:518.56Irinotecan hydrochloride trihydrate
CAS:Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.Fórmula:C33H45ClN4O9Pureza:98.22% - >99.99%Forma y color:Pale Yellow To Yellow Crystalline PowderPeso molecular:677.18Irinotecan Hydrochloride
CAS:Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.Fórmula:C33H39ClN4O6Pureza:98% - 99.94%Forma y color:Yellow Crystalline PowderPeso molecular:623.14XR-11576 HCl
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.Fórmula:C23H25ClN4O2Pureza:98.52%Forma y color:SoildPeso molecular:424.92DRF-1042 HCl
DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, and is used in the study of refractory solid tumors.Fórmula:C22H21ClN2O6Pureza:97.93%Forma y color:SolidPeso molecular:444.87Topotecan hydrochloride
CAS:Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.Fórmula:C23H24ClN3O5Pureza:97.88% - 99.41%Forma y color:White Crystalline SolidPeso molecular:457.92Epirubicin hydrochloride
CAS:Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective and quality-assured.Fórmula:C27H30ClNO11Pureza:98.13% - 99.79%Forma y color:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Peso molecular:579.98Hycanthone
CAS:<p>Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.</p>Fórmula:C20H24N2O2SPureza:98.78%Forma y color:Yellow-Orange Powder (Ntp 1992)Peso molecular:356.48Levofloxacin hydrate
CAS:Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Fórmula:C18H20FN3O4H2OPureza:98.26%Forma y color:Pale Yellow SolidPeso molecular:370.38Etoposide
CAS:<p>Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).</p>Fórmula:C29H32O13Pureza:99.19% - 99.94%Forma y color:Crystals From Methanol SolidPeso molecular:588.56Gatifloxacin
CAS:Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.Fórmula:C19H22FN3O4Pureza:99.50% - 99.85%Forma y color:White PowderPeso molecular:375.39Mitoxantrone dihydrochloride
CAS:<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>Fórmula:C22H30Cl2N4O6Pureza:97.05% - >99.99%Forma y color:Blue-Black Solid From Water Ethanol SolidPeso molecular:517.4Moxifloxacin hydrochloride
CAS:Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria and atypical pathogens.Fórmula:C21H25ClFN3O4Pureza:99.91% - >99.99%Forma y color:SolidPeso molecular:437.89Pefloxacin Mesylate
CAS:Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-Fórmula:C18H24FN3O6SPureza:99.86%Forma y color:SolidPeso molecular:429.46Nalidixic acid
CAS:Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.Fórmula:C12H12N2O3Pureza:99.9% - 99.95%Forma y color:Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Peso molecular:232.24Ciprofloxacin
CAS:Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). antibiotic. High-Quality, Low-Cost!Fórmula:C17H18FN3O3Pureza:98.77% - 99.91%Forma y color:White PowderPeso molecular:331.34Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Fórmula:C27H29NO11·HClPureza:98% - 99.52%Forma y color:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Peso molecular:579.99Oxaquin TEA
<p>Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that can be used to study Clostridium difficile infections and</p>Fórmula:C37H48F2N5O11PPureza:99.79%Forma y color:SolidPeso molecular:807.77Enoxacin hydrate
CAS:<p>Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.</p>Fórmula:C15H17FN4O3H2OPureza:99.50%Forma y color:SolidPeso molecular:347.34Berberine chloride
CAS:Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.Fórmula:C20H18ClNO4Pureza:99.47% - 99.93%Forma y color:Yellow Crystalline PowderPeso molecular:371.80Lomefloxacin
CAS:Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.Fórmula:C17H19F2N3O3Pureza:98.59%Forma y color:Off-White To Yellow CrystalsPeso molecular:351.35Teniposide
CAS:Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II andFórmula:C32H32O13SPureza:97.7% - 99.45%Forma y color:White Or Off-White Crystalline PowderPeso molecular:656.65Flumequine
CAS:Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.Fórmula:C14H12FNO3Pureza:98.92% - 99.4%Forma y color:White Crystalline Powder SolidPeso molecular:261.25Enoxacin
CAS:Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Fórmula:C15H17FN4O3Pureza:98.68% - 99.89%Forma y color:Off-White To Yellow CrystalsPeso molecular:320.32Ciprofloxacin monohydrochloride
CAS:Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.Fórmula:C17H18FN3O3·HClPureza:99.5% - 99.73%Forma y color:White Or Light Yellow Crystalline PowderPeso molecular:367.80AuM1Phe
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization.Pureza:98%Forma y color:Odour SolidAuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the lowPureza:98%Forma y color:Odour SolidDNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Forma y color:Odour SolidDTS-108
CAS:DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.Fórmula:C145H233N43O33S2Forma y color:SolidPeso molecular:3170.8NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC)Fórmula:C26H24ClN3O6Pureza:98%Forma y color:SolidPeso molecular:509.94Voreloxin
CAS:Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Fórmula:C18H19N5O4SPureza:98%Forma y color:SolidPeso molecular:401.44Topoisomerase I inhibitor 10
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity.Pureza:98%Forma y color:Odour SolidCH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Fórmula:C26H26N4O4Pureza:98%Forma y color:SolidPeso molecular:458.51Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Fórmula:C23H20F2N2O4Pureza:98%Forma y color:SolidPeso molecular:426.41Dichlorogelignate
CAS:Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].Fórmula:C32H34O18Forma y color:SolidPeso molecular:706.6Banoxantrone-d12 dihydrochloride
CAS:Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.Fórmula:C22H30Cl2N4O6Pureza:98%Forma y color:SolidPeso molecular:529.48CBX-12
CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.Fórmula:C169H240FN35O49S2Peso molecular:3629.05Topoisomerase II inhibitor 13
CAS:WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.Fórmula:C22H23N9Pureza:99.84%Forma y color:SoildPeso molecular:413.48Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Fórmula:C25H26ClN3O5Pureza:97.04%Forma y color:SoildPeso molecular:483.94Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Fórmula:C21H21N3O2Forma y color:SolidPeso molecular:347.41Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Fórmula:C53H83FN6O15Forma y color:SolidPeso molecular:1063.26Banoxantrone (D12)
CAS:Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.Fórmula:C22H28N4O6Pureza:98%Forma y color:SolidPeso molecular:456.55TAK1 inhibitor
CAS:<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Fórmula:C22H19ClN6O2SPureza:98%Forma y color:SoildPeso molecular:466.94Topoisomerase IIα-IN-9
CAS:Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C14H14O4SForma y color:SolidPeso molecular:278.32Chimmitecan
CAS:<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Fórmula:C23H20N2O5Pureza:98.35%Forma y color:SoildPeso molecular:404.42Topo I/II-IN-1
<p>Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.</p>Fórmula:C15H13N3S2Forma y color:SolidPeso molecular:299.414AuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Fórmula:C29H50AuCl2N5Forma y color:SolidPeso molecular:736.61Antitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targetsFórmula:C70H82N8O18SPureza:98%Forma y color:SolidPeso molecular:1355.51
