Topoisomerasa
Las topoisomerasas son enzimas que regulan la topología del ADN durante procesos como la replicación, transcripción y segregación de cromosomas, introduciendo rupturas transitorias en las hebras de ADN para aliviar el estrés torsional. Los inhibidores de topoisomerasa interfieren con este proceso, lo que lleva a la acumulación de rupturas en el ADN y la inducción de la muerte celular, particularmente en células que se dividen rápidamente. Estos inhibidores se utilizan ampliamente como agentes quimioterapéuticos en el tratamiento del cáncer. En CymitQuimica, ofrecemos una amplia gama de inhibidores de topoisomerasa de alta calidad para apoyar su investigación en replicación del ADN, terapia contra el cáncer y regulación del ciclo celular.
Se han encontrado 136 productos de "Topoisomerasa"
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Isosteviol
CAS:Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.Fórmula:C20H30O3Pureza:99.72% - 99.97%Forma y color:SolidPeso molecular:318.45SW044248
CAS:SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.Fórmula:C22H23N5O2SPureza:99.56% - 99.87%Forma y color:SolidPeso molecular:421.52Niranthin
CAS:Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L.Fórmula:C24H32O7Pureza:99.8%Forma y color:SolidPeso molecular:432.51Ref: TM-TN4660
1mg345,00€5mg762,00€10mg1.144,00€25mg2.008,00€50mg3.213,00€100mg5.139,00€1mL*10mM (DMSO)808,00€Topovale
CAS:Topovale (ARC111) is a potent inhibitor of topoisomerase I.Fórmula:C23H23N3O5Pureza:99.94%Forma y color:SolidPeso molecular:421.45Pirarubicin
CAS:Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.Fórmula:C32H37NO12Pureza:97.80% - 99.15%Forma y color:Red Crystalline PowderPeso molecular:627.64Garenoxacin mesylate hydrate
CAS:Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strainsFórmula:C23H20F2N2O4·CH4O3S·H2OPureza:99.56%Forma y color:SolidPeso molecular:540.53Exatecan Mesylate
CAS:Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).Fórmula:C25H26FN3O7SPureza:97.32% - 99.9%Forma y color:SolidPeso molecular:531.55Indotecan
CAS:Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).Fórmula:C26H26N2O7Pureza:97% - 98%Forma y color:SolidPeso molecular:478.49Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 99.55%Forma y color:SolidPeso molecular:383.82Prulifloxacin
CAS:Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.Fórmula:C21H20FN3O6SPureza:99.47%Forma y color:Yellow Or Slightly Yellow PowerPeso molecular:461.46Rabdosiin
CAS:Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.Fórmula:C36H30O16Pureza:98.64% - 99.49%Forma y color:SolidPeso molecular:718.619-Methoxycamptothecin
CAS:9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Fórmula:C21H18N2O5Pureza:98.49% - 99.56%Forma y color:SolidPeso molecular:378.38Mitoxantrone
CAS:<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Fórmula:C22H28N4O6Pureza:96.29% - 98.74%Forma y color:Blue PowderPeso molecular:444.48β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Fórmula:C15H14O3Pureza:99.76% - 99.88%Forma y color:SolidPeso molecular:242.27Ellipticine hydrochloride
CAS:Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.Fórmula:C17H15ClN2Pureza:97.18%Forma y color:SolidPeso molecular:282.76Amonafide
CAS:Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.Fórmula:C16H17N3O2Pureza:99.39%Forma y color:SolidPeso molecular:283.33Ref: TM-T6336
1mg39,00€2mg51,00€5mg80,00€10mg87,00€25mg163,00€50mg281,00€100mg467,00€1mL*10mM (DMSO)92,00€Groenlandicine
CAS:Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.Fórmula:C19H16NO4Pureza:98.59% - 99.77%Forma y color:SolidPeso molecular:322.34Irinotecan
CAS:Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Fórmula:C33H38N4O6Pureza:98% - 99.92%Forma y color:SolidPeso molecular:586.68Dxd
CAS:Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs. High-Quality, Low-Cost!Fórmula:C26H24FN3O6Pureza:98.21% - ≥98%Forma y color:SolidPeso molecular:493.481,4-Naphthoquinone
CAS:1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Fórmula:C10H6O2Pureza:99.24% - 99.56%Forma y color:SolidPeso molecular:158.15
