Topoisomerasa
Las topoisomerasas son enzimas que regulan la topología del ADN durante procesos como la replicación, transcripción y segregación de cromosomas, introduciendo rupturas transitorias en las hebras de ADN para aliviar el estrés torsional. Los inhibidores de topoisomerasa interfieren con este proceso, lo que lleva a la acumulación de rupturas en el ADN y la inducción de la muerte celular, particularmente en células que se dividen rápidamente. Estos inhibidores se utilizan ampliamente como agentes quimioterapéuticos en el tratamiento del cáncer. En CymitQuimica, ofrecemos una amplia gama de inhibidores de topoisomerasa de alta calidad para apoyar su investigación en replicación del ADN, terapia contra el cáncer y regulación del ciclo celular.
Se han encontrado 139 productos de "Topoisomerasa"
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Topoisomerase II inhibitor 13
CAS:WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.Fórmula:C22H23N9Pureza:99.84%Forma y color:SoildPeso molecular:413.48Voreloxin
CAS:Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Fórmula:C18H19N5O4SPureza:98%Forma y color:SolidPeso molecular:401.44Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Fórmula:C21H21N3O2Forma y color:SolidPeso molecular:347.41CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Fórmula:C26H26N4O4Pureza:98%Forma y color:SolidPeso molecular:458.51Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Fórmula:C25H26ClN3O5Pureza:97.04%Forma y color:SoildPeso molecular:483.94TAK1 inhibitor
CAS:<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Fórmula:C22H19ClN6O2SPureza:98%Forma y color:SoildPeso molecular:466.94Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Fórmula:C53H83FN6O15Forma y color:SolidPeso molecular:1063.26AuL1
AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.Fórmula:C29H50AuCl2N5Forma y color:SolidPeso molecular:736.61CBX-12
CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.Fórmula:C169H240FN35O49S2Peso molecular:3629.05Dichlorogelignate
CAS:Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].Fórmula:C32H34O18Forma y color:SolidPeso molecular:706.6(4-NH2)-Exatecan
CAS:(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).Fórmula:C23H21N3O4Pureza:99.89%Forma y color:SolidPeso molecular:403.43Daun02
CAS:Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.Fórmula:C41H44N2O20Pureza:98%Forma y color:SolidPeso molecular:884.791,4-Naphthoquinone
CAS:1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Fórmula:C10H6O2Pureza:99.24% - 99.56%Forma y color:SolidPeso molecular:158.15Genz-644282
CAS:Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Fórmula:C22H21N3O5Pureza:97.49%Forma y color:SolidPeso molecular:407.42Ref: TM-T4S0797
5mgA consultar10mgA consultar25mgA consultar50mg93,00€100mg125,00€500mg266,00€1mL*10mM (DMSO)55,00€SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Fórmula:C22H20N2O5Pureza:98% - 99.97%Forma y color:Light-Yellow SolidPeso molecular:392.4Aurintricarboxylic acid
CAS:Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Fórmula:C22H14O9Pureza:97.1%Forma y color:Deep Red Coarse Crystalline PowderPeso molecular:422.34Voreloxin hydrochloride
CAS:Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Fórmula:C18H20ClN5O4SPureza:99.84%Forma y color:SolidPeso molecular:437.9Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Fórmula:C26H27NO9·HClPureza:98.91% - 99.96%Forma y color:SolidPeso molecular:533.95Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Fórmula:C15H12O3Pureza:98.07% - 99.18%Forma y color:SolidPeso molecular:240.25Ref: TM-T16522
1mg66,00€5mg144,00€10mg227,00€25mg373,00€50mg567,00€100mg810,00€1mL*10mM (DMSO)159,00€
