Inmunología e inflamación
Los inhibidores de inmunología e inflamación son compuestos que modulan la respuesta inmunitaria y los procesos inflamatorios. Estos inhibidores son cruciales para estudiar los mecanismos de regulación inmunitaria, la autoinmunidad y la inflamación crónica, así como para desarrollar tratamientos para enfermedades inflamatorias, alergias y trastornos relacionados con el sistema inmunológico. Al dirigirse a vías clave en el sistema inmunológico, estos inhibidores pueden ayudar a reducir las respuestas inmunitarias excesivas o inadecuadas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Subcategorías de "Inmunología e inflamación"
- CCR(136 productos)
- CXCR(148 productos)
- Pared celular(5 productos)
- Receptor de IL(112 productos)
- IκB / IKK(60 productos)
- LTR(3 productos)
- MALT(23 productos)
- MRP(6 productos)
- NADPH-oxidasa(1 productos)
- NF-κB(444 productos)
- NOD(17 productos)
- NOS(63 productos)
- Nrf2(79 productos)
- PGE sintasa(31 productos)
- ROS(69 productos)
- TGF-beta / Smad(58 productos)
- TLR(66 productos)
- Tiorredoxina(12 productos)
- gp120 / CD4(4 productos)
Mostrar 11 subcategorías más
Se han encontrado 3045 productos de "Inmunología e inflamación"
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NLRP3-IN-58
CAS:<p>NLRP3-IN-58 (Compound DS15) acts as an inhibitor of NLRP3 inflammasome activation, with an IC50 value of 3.85 μM, and is capable of inhibiting 33% of IL-1β release at a concentration of 10 μM.</p>Fórmula:C22H18ClN3O3SForma y color:SolidPeso molecular:439.92STING agonist-42
CAS:<p>STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.</p>Fórmula:C17H8F2LiN5O3Forma y color:SolidPeso molecular:375.22NLRP3-IN-70
CAS:<p>NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.</p>Fórmula:C23H23NO5Forma y color:SolidPeso molecular:393.432MG-T-19
CAS:<p>MG-T-19, a TIM-3 inhibitor, inhibit the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs.</p>Fórmula:C18H8Br2ClF3N4O2SPureza:99.14%Forma y color:SolidPeso molecular:596.6STING-IN-15
CAS:<p>STING-IN-15 (compound 66) is a potent STING inhibitor, effectively suppressing human and mouse STING with IC50 values of 116 nM and 96.3 nM, respectively. In the REX1 D18N mouse model, STING-IN-15 significantly reduces tissue damage and inflammation.</p>Fórmula:C20H14F2N4O3Forma y color:SolidPeso molecular:396.35NLRP3-IN-80
CAS:<p>NLRP3-IN-80 (Compound 1) is an NLRP3 inhibitor useful for research into inflammatory aging.</p>Fórmula:C24H22F2N4O3Forma y color:SolidPeso molecular:452.45NP3-146 sodium
CAS:<p>NP3-146 sodium is an inhibitor of the NLRP3 inflammasome.</p>Fórmula:C20H26ClN2NaO5SForma y color:SolidPeso molecular:464.94AS2690168 hydrochloride
CAS:<p>AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Fórmula:C17H15Cl2F3N4OForma y color:SolidPeso molecular:419.228mPGES1-IN-9
CAS:<p>mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.</p>Fórmula:C25H18N4OSForma y color:SolidPeso molecular:422.502FK-565
CAS:<p>FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.</p>Fórmula:C22H38N4O9Forma y color:SolidPeso molecular:502.559AS2690168 (free base)
CAS:<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Fórmula:C17H13F3N4OForma y color:SolidPeso molecular:346.306(Rel)-Factor B-IN-5
CAS:<p>(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.</p>Fórmula:C27H32N2O4Pureza:>99.99%Forma y color:SolidPeso molecular:448.55CD73-IN-19
CAS:<p>CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.</p>Fórmula:C18H17N3O3SForma y color:SolidPeso molecular:355.411LHC-165
CAS:<p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>Fórmula:C29H32F2N3O7PPureza:98%Forma y color:SolidPeso molecular:603.55G108
CAS:<p>G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.</p>Fórmula:C16H14Cl2N4O2Pureza:99.13% - 99.75%Forma y color:SolidPeso molecular:365.21SP4206
CAS:<p>SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)</p>Fórmula:C30H37Cl2N7O6Pureza:98%Forma y color:SolidPeso molecular:662.56oxLig-1
CAS:<p>OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).</p>Fórmula:C36H58O5Forma y color:SolidPeso molecular:570.84Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Fórmula:C22H20O12Forma y color:SolidPeso molecular:476.39OP-5244 sodium
<p>OP-5244 sodium: potent oral CD73 inhibitor (IC50: 0.25 nM), potential in cancer research by hindering adenosine, reversing immunosuppression.</p>Fórmula:C19H28ClN5NaO9PForma y color:SolidPeso molecular:559.87RGT-068A
CAS:<p>RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .</p>Fórmula:C17H16ClN9O2Forma y color:SolidPeso molecular:413.82COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Fórmula:C25H23N5O4S2Forma y color:SolidPeso molecular:521.61C5aR-IN-3
CAS:<p>C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.</p>Fórmula:C36H40FN5O3Forma y color:SolidPeso molecular:609.73Nrf2 activator-6
CAS:<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Fórmula:C31H37ClFN5O5Forma y color:SolidPeso molecular:614.11AIM4
CAS:<p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>Fórmula:C25H23Br2N5O4Forma y color:SolidPeso molecular:617.289TLR7/8 antagonist 1
<p>Compound 16c, an imidazoquinoline, is a TLR7/8 agonist; IC50: 3.91 μM (TLR7), 2.19 μM (TLR8); targets TLR-2050 for disease treatment.</p>Fórmula:C24H27N5O2Forma y color:SolidPeso molecular:417.5SARM1-IN-4
CAS:<p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>Fórmula:C13H17F2N3O2Forma y color:SolidPeso molecular:285.29COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Fórmula:C19H14ClN5S2Forma y color:SolidPeso molecular:411.93STING agonist-20
CAS:<p>STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.</p>Fórmula:C36H39N11O8Forma y color:SolidPeso molecular:753.76Antioxidant agent-3
<p>Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.</p>Fórmula:C18H14O8Forma y color:SolidPeso molecular:358.3NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Fórmula:C18H15ClN2O4S3Forma y color:SolidPeso molecular:454.97SMW139
CAS:<p>SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.</p>Fórmula:C19H21ClF3NO2Forma y color:SolidPeso molecular:387.824COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Fórmula:C15H10ClIN2OForma y color:SolidPeso molecular:396.61CPDT
CAS:<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Fórmula:C6H6S3Forma y color:SolidPeso molecular:174.307Gardiquimod hydrochloride
CAS:<p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>Fórmula:C17H24ClN5OForma y color:SolidPeso molecular:349.858IACS-8779 disodium
CAS:<p>IACS-8779 disodium: potent STING agonist, strong systemic anti-tumor effects, effective in melanoma model.</p>Fórmula:C21H23N9Na2O10P2S2Forma y color:SolidPeso molecular:733.52COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Fórmula:C22H23FN2O6S2Forma y color:SolidPeso molecular:494.56IL-17 modulator 1 disodium
CAS:<p>Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.</p>Fórmula:C28H37N6NaO6PForma y color:SolidPeso molecular:607.604TIM-3-IN-1
<p>TIM-3-IN-1 is a useful tool to enable further studies on the biology of TIM-3 immunoregulation in cancer.</p>Fórmula:C20H16ClN7O3SForma y color:SolidPeso molecular:469.9MSA-2 dimer
CAS:<p>MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.</p>Fórmula:C29H28O8S2Forma y color:SolidPeso molecular:568.66Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Fórmula:C18H15N5O2SForma y color:SolidPeso molecular:365.41IKZF2-degrader 1
CAS:<p>IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.</p>Fórmula:C27H30FN7O3Forma y color:SolidPeso molecular:519.57Balsalazide disodium
CAS:<p>Balsalazide disodium is an aminosalicylate prodrug that releases mesalamine in the colon, providing diverse anti-inflammatory effects in regions affected by colitis. Additionally, it exhibits anticancer properties by modulating the IL-6/STAT3 pathway.</p>Fórmula:C17H13N3Na2O6Forma y color:SolidPeso molecular:401.281C-di-IMP
CAS:<p>Cyclic-di-IMP (C-di-IMP), a STING agonist, serves as a research tool in tumor studies.</p>Fórmula:C20H22N8O14P2Forma y color:SolidPeso molecular:660.386-Alkyne-F-araNAD
CAS:<p>6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).</p>Fórmula:C24H28FN7O13P2Forma y color:SolidPeso molecular:703.464MMG-11 quarterhydrate
<p>MMG-11 quarterhydrate, a potent hTLR2 antagonist, inhibits TLR2/1 and TLR2/6 with IC50s of 1.7μM and 5.7μM; low toxicity.</p>Fórmula:C15H16O8Forma y color:SolidPeso molecular:310.78Polvitolimod
CAS:<p>Polvitolimod is a TLR7 agonist used to treat infectious disease and cancer.</p>Fórmula:C13H14FN5O4Forma y color:SolidPeso molecular:323.28NF-κB-IN-6
<p>NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signaling</p>Fórmula:C14H20N2O3Forma y color:SolidPeso molecular:264.32IRAK4 ligand-13
CAS:<p>IRAK4ligand-13 is an IRAK4 ligand and serves as a PROTAC target protein ligand. It is utilized in the synthesis of PROTAC compounds, such as LZ-07.</p>Fórmula:C23H26N10Forma y color:SolidPeso molecular:442.52BAA473
<p>BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.</p>Fórmula:C36H62O5Pureza:98%Forma y color:SolidPeso molecular:574.87Fexlamose
CAS:<p>Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).</p>Fórmula:C12H22O9S2Forma y color:SolidPeso molecular:374.428TLR7/8 antagonist 2
<p>TLR7/8 antagonist 2: potent, orally active, IC50: 4.9 nM (TLR7), 0.6 nM (TLR8); potential for lupus therapy research.</p>Fórmula:C22H26FN5Forma y color:SolidPeso molecular:379.47IRAK4-IN-11
<p>IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1].</p>Fórmula:C16H19N7OForma y color:SolidPeso molecular:325.37IACS-8779
CAS:<p>IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.</p>Fórmula:C21H25N9O10P2S2Pureza:98%Forma y color:SolidPeso molecular:689.55NLRP3-IN-4
<p>NLRP3-IN-4 is an effective, oral NLRP3 inflammasome inhibitor with potent anti-inflammatory effects on colitis.</p>Fórmula:C22H22N2O5Forma y color:SolidPeso molecular:394.42IL-17 modulator 5
CAS:<p>IL-17 modulator 5 is a IL-17 inhibitor, with an IC 50 of 1 nM .</p>Fórmula:C28H23F6N9O2Forma y color:SolidPeso molecular:631.53(S,R,S)-AHPC-Boc derivative 1
CAS:<p>(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).</p>Fórmula:C28H40N4O6SForma y color:SolidPeso molecular:560.705K-14585
CAS:<p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>Fórmula:C51H56Cl2N8O4Forma y color:SolidPeso molecular:915.95Nrf2 activator-2
<p>Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.</p>Fórmula:C20H17BrO3Forma y color:SolidPeso molecular:385.25Nitric oxide production-IN-2
CAS:<p>TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.</p>Fórmula:C23H20O3Forma y color:SolidPeso molecular:344.403TLR7/8 agonist 7
CAS:<p>TLR7/8 agonist 7 activates immune cells, useful in ISAC synthesis and immunity research.</p>Fórmula:C26H37N7O2Forma y color:SolidPeso molecular:479.62GNE-2256
CAS:<p>GNE-2256, also known as molecule 19, is an orally active compound that inhibits Interleukin 1 receptor-associated kinase 4 (IRAK4) with a K i of 1.4 nM and has</p>Fórmula:C24H27FN6O4Forma y color:SolidPeso molecular:482.51MAO-B-IN-7
<p>MAO-B-IN-7 inhibits MAO-B/AChE, crossing the blood-brain barrier; IC50: 41/87 nM (h/eel AChE), 0.3 μM (MAO-B). Reduces oxidative stress and neuroinflammation.</p>Fórmula:C25H31NO4Forma y color:SolidPeso molecular:409.52ODN 21158
CAS:<p>ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.</p>Forma y color:SolidIRAK4-IN-14
CAS:<p>IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.</p>Fórmula:C25H28FN9OForma y color:SolidPeso molecular:489.55ROS inducer 9
CAS:<p>ROS inducer 9 (compound 4e) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Escherichia coli. It eradicates bacteria by inhibiting GSH activity and increasing ROS levels. Additionally, ROS inducer 9 exhibits low toxicity toward red blood cells and RAW 264.7 cells.</p>Fórmula:C26H26BrF4N3O3Forma y color:SolidPeso molecular:584.401CVN293
CAS:<p>CVN293 is a inhibitor of the potassium channel KCNK13,BBB,It inhibits the production of the pro-inflammatory cytokine IL-1β induced by NLRP3 in microglia</p>Fórmula:C14H10FN7OPureza:99.50%Forma y color:SolidPeso molecular:311.27Heme Oxygenase-1-IN-2
<p>Heme Oxygenase-1-IN-2 is a novel inhibitor of heme oxygenase-1 (HO-1), displaying potent antiproliferative activity in vitro, with an IC50 value of 0.95 μM.</p>Fórmula:C19H18ClN3OForma y color:SolidPeso molecular:339.82CD73-IN-13
<p>CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.</p>Fórmula:C13H11F3N4O2Forma y color:SolidPeso molecular:312.25Anti-inflammatory agent 102
CAS:<p>Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).</p>Fórmula:C16H16ClN3O3Forma y color:SolidPeso molecular:333.77MALT1-IN-5
CAS:<p>MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.</p>Fórmula:C17H17ClF2N6O3Forma y color:SolidPeso molecular:426.80Itaconic acid prodrug-1
CAS:<p>Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.</p>Fórmula:C15H22O10Forma y color:SolidPeso molecular:362.329COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Fórmula:C17H19NO3Forma y color:SolidPeso molecular:285.34ODN 2088
CAS:<p>ODN 2088 is a potent inhibitor of TLR3, TLR7 and TLR9 that is non-cytotoxic and shows inhibition of the release of IFN-α and IL-6.</p>Forma y color:SolidCorannulene
CAS:<p>Corannulene is an agonist of the aromatic hydrocarbon receptor (AhR). It induces a lower cytotoxic response in liver cancer cells compared to Benzo[a]pyrene and shows potential for use in cancer research.</p>Fórmula:C20H10Forma y color:SolidPeso molecular:250.293MAY0132
CAS:<p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>Fórmula:C16H15ClF3NForma y color:SolidPeso molecular:313.7452-Guanidinobezimidazole
CAS:<p>2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB).</p>Fórmula:C8H9N5Forma y color:SolidPeso molecular:175.191TLR7 agonist 28
CAS:<p>TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.</p>Fórmula:C26H25N9O7Forma y color:SolidPeso molecular:575.533iNOs-IN-1
<p>iNOs-IN-1 (YPW) is a strong iNOS inhibitor with dose-dependent anti-inflammatory properties, reducing IL-6, iNOS, and NO levels.</p>Fórmula:C25H30N4O5Forma y color:SolidPeso molecular:466.53NDT-30805
<p>NDT-30805, a triazolopyridine, blocks IL-1β in PBMC (IC50: 0.013μM) & NLRP3 inflammasome, for inflammation research.</p>Fórmula:C23H22N6SForma y color:SolidPeso molecular:414.53BMS-986458
CAS:<p>BMS-986458 is a highly selective, orally active BCL6 PROTAC degrader. It specifically targets cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity-induced BCL6 degradation. BMS-986458 is applicable for research in B-cell non-Hodgkin lymphoma.</p>Fórmula:C32H34ClN9O3Forma y color:SolidPeso molecular:628.124NLRP3-IN-8
CAS:<p>NLRP3-IN-8, orally active inflammasome blocker, IC50 of 1.23μM, stable (t1/2 = 138.63min), non-toxic (IC50 >100μM).</p>Fórmula:C23H20N2O6Forma y color:SolidPeso molecular:420.41AMS-17
<p>AMS-17, a strong NLRP3 inhibitor, quells microglia activation and cytokines like caspase-1, TNF-α, IL-1β, iNOS in studies.</p>Fórmula:C15H13F3N4O3SForma y color:SolidPeso molecular:386.35HPK1-IN-56
CAS:<p>HPK1-IN-56 (Compound A29) is an HPK1 inhibitor with an IC50 of 2.70 nM. It inhibits downstream p-SLP76 in Jurkat T cells with an IC50 of 8.1 nM. Additionally, HPK1-IN-56 induces IL-2 production in human PBMCs. This compound exhibits anticancer properties, enhancing T cell cytotoxicity and the antitumor efficacy of anti-PD-1 antibodies.</p>Fórmula:C24H26N8OForma y color:SolidPeso molecular:442.516mPGES-1-IN-1
<p>MPGES-1, potential anti-inflammatory drug target, has IC50 of 0.03 μM with mPGES-1-IN-1.</p>Fórmula:C21H14N4O2SForma y color:SolidPeso molecular:386.43COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Fórmula:C19H18N2O5SForma y color:SolidPeso molecular:386.42COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Fórmula:C19H19N3O4S2Forma y color:SolidPeso molecular:417.5SP11
CAS:<p>SP11 is a mitochondrial reactive oxygen species (ROS) inhibitor. It activates Fis1 with an IC50 of 9.4 µM by binding to Cys41 and enhances the translocation of Drp1 to mitochondria. SP11 is utilized for research into oxidative stress damage.</p>Fórmula:C18H19ClN2OSForma y color:SolidPeso molecular:346.87Ambuic acid
CAS:<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Fórmula:C19H26O6Forma y color:SolidPeso molecular:350.41COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Fórmula:C31H32FN5O2SForma y color:SolidPeso molecular:557.68Galectin-3-IN-2
<p>Galectin-3-IN-2 inhibits galactose lectin-3 (Gal-3) with an 8.3 μM IC50, impacting cancer-related metabolism.</p>Fórmula:C24H30FN3O10SForma y color:SolidPeso molecular:571.57ZM514
<p>ZM514 inhibits CD73 (hCD73 IC50: 1.39 μM, mCD73 IC50: 14.65 μM) with low cytotoxicity, suitable for cancer research.</p>Fórmula:C36H57NO4Forma y color:SolidPeso molecular:567.84IRAK4-IN-18
<p>IRAK4-IN-18: Potent IRAK4 inhibitor (IC50: 15 nM), reduces IL23 in cells, prevents rat arthritis.</p>Fórmula:C24H25FN6O3Forma y color:SolidPeso molecular:464.49DBMB
CAS:<p>DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.</p>Fórmula:C24H22N4OForma y color:SolidPeso molecular:382.458AhR agonist 2
<p>AhR agonist 2 is aryl hydrocarbon receptor (AhR) agonist,oral, inducing rapid nuclear enrichment of the AhR and facilitating skin barrier repair,psoriasis.</p>Fórmula:C12H7Br2N3Forma y color:SolidPeso molecular:353.01ND-2158
CAS:<p>ND-2158 is a potent and selective inhibitor of IRAK4.</p>Fórmula:C22H30N4O4SPureza:98%Forma y color:SolidPeso molecular:446.56TLR4/NF-κB/MAPK-IN-1
CAS:<p>TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.</p>Fórmula:C19H25BrO6Forma y color:SolidPeso molecular:429.3CD73-IN-2
<p>CD73-IN-2 is a potent inhibitor of CD73 (IC50: 0.09 nM).</p>Fórmula:C17H25ClN5O7PForma y color:SolidPeso molecular:477.84nNOS-IN-5
CAS:<p>nNOS-IN-5 (Compound 9) is a potent inhibitor of human neuronal nitric oxide synthase (nNOS) with a Ki of 22 nM. It exhibits remarkable selectivity, being 900 times more selective for human nNOS over endothelial nitric oxide synthase (eNOS). nNOS-IN-5 is applicable in research related to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>Fórmula:C23H22N4OForma y color:SolidPeso molecular:370.447NOD1/2 antagonist-1
CAS:<p>NOD1/2 antagonist-1 inhibits NOD1 (IC50 1.13 μM) and NOD2 (IC50 0.77 μM), enhances paclitaxel antitumor efficacy and is used to study innate immune signaling.</p>Fórmula:C32H28ClF5N4O4Pureza:99.69%Forma y color:SolidPeso molecular:663.03Rafutrombopag
CAS:<p>Rafutrombopag is a thrombopoietin (TPO) agonist.</p>Fórmula:C25H22N4O5Forma y color:SolidPeso molecular:458.47
