Inmunología e inflamación
Los inhibidores de inmunología e inflamación son compuestos que modulan la respuesta inmunitaria y los procesos inflamatorios. Estos inhibidores son cruciales para estudiar los mecanismos de regulación inmunitaria, la autoinmunidad y la inflamación crónica, así como para desarrollar tratamientos para enfermedades inflamatorias, alergias y trastornos relacionados con el sistema inmunológico. Al dirigirse a vías clave en el sistema inmunológico, estos inhibidores pueden ayudar a reducir las respuestas inmunitarias excesivas o inadecuadas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Subcategorías de "Inmunología e inflamación"
- CCR(136 productos)
- CXCR(149 productos)
- Pared celular(5 productos)
- Receptor de IL(112 productos)
- IκB / IKK(59 productos)
- LTR(3 productos)
- MALT(23 productos)
- MRP(6 productos)
- NADPH-oxidasa(1 productos)
- NF-κB(443 productos)
- NOD(18 productos)
- NOS(63 productos)
- Nrf2(78 productos)
- PGE sintasa(31 productos)
- ROS(69 productos)
- TGF-beta / Smad(58 productos)
- TLR(66 productos)
- Tiorredoxina(12 productos)
- gp120 / CD4(4 productos)
Mostrar 11 subcategorías más
Se han encontrado 3054 productos de "Inmunología e inflamación"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Anticonvulsant agent 10
<p>Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.</p>Forma y color:Odour SolidAntifungal agent 123
<p>Antifungalagent 123 (Compound 4b) demonstrates strong affinity for the oxidoreductase of Staphylococcus aureus or membrane proteins of Candida albicans, exhibiting both antibacterial and antifungal properties. Additionally, it is capable of scavenging free radicals, showcasing antioxidant effects. Antifungalagent 123 also inhibits the TLR signaling pathway and possesses anti-inflammatory activity.</p>Fórmula:C21H20N4O3Forma y color:SolidPeso molecular:376.409IACS-8803 disodium
CAS:<p>IACS-8803 Disodium, a potent cyclic dinucleotide STING agonist, exhibits strong systemic antitumor efficacy [1].</p>Fórmula:C20H21FN10Na2O9P2S2Forma y color:SolidPeso molecular:736.50PF-06426779
CAS:<p>PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4) , with an IC 50 of 0.3 nM.</p>Fórmula:C17H18FN3O4Forma y color:SolidPeso molecular:347.346Guignardone L
CAS:<p>Guignardone L, a metabolite extracted from the endophytic fungus Guignardia mangiferae, possesses toll-like receptor 3 (TLR3) regulating activity [1].</p>Fórmula:C17H24O4Forma y color:SolidPeso molecular:292.37Cbl-b-IN-28
<p>Cbl-b-IN-28 (Compound B2) is an orally active Cbl-b inhibitor. It enhances the function of immune cells by promoting the secretion of cytokines like IL-2 and modulating the phosphorylation levels of key proteins in the T cell receptor signaling pathway. Cbl-b-IN-28 is applicable in cancer immunology research.</p>Forma y color:Odour SolidCartap hydrochloride
CAS:<p>Cartap hydrochloride is an insecticidal derivative. It is used to control chewing and sucking insects on many crops.</p>Fórmula:C18H33Cl2CuN3O3Forma y color:Colorless Crystalline Slightly Hygroscopic Solid CoaPeso molecular:473.93Romilkimab
CAS:<p>Romilkimab (SAR156597) is a chimeric humanized immunoglobulin (Ig) antibody designed to specifically target interleukins 4 and 13 (IL-4 and IL-13) [1].</p>Forma y color:LiquidIL-17-IN-3
<p>IL-17-IN-3 (compound 11) is an IL-17A inhibitor with an IC50 value of 35 nM. In a rat tolerance study, it showed no adverse reactions when administered at doses up to 300 mg/kg/day for four consecutive days.</p>Fórmula:C22H25F6N5O3SForma y color:SolidPeso molecular:553.521STING agonist-25
CAS:<p>STING agonist-25 is a non-nucleotide that activates STING, enhances immune response, and is active against SARS-CoV strains.</p>Fórmula:C36H41N13O6Forma y color:SolidPeso molecular:751.79FLY26
<p>FLY26 is a selective partial antagonist of GluN2B, with an IC50 value of 0.64 μM. FLY26 inhibits the GluN2B subunit of NMDA receptors, reducing calcium ion influx and reactive oxygen species (ROS) production. It also activates the BDNF/TrkB/CREB neuroprotective signaling pathway, mitigating excitotoxicity and mitochondrial dysfunction. FLY26 holds potential for treating neurological deficits caused by cerebral ischemia-reperfusion injury.</p>Fórmula:C22H23N5O3Forma y color:SolidPeso molecular:405.18009FGT-4
<p>FGT-4 is a chimeric molecule targeting folate receptor β (FR-β) and functions as a TLR7 agonist. It enhances the secretion of iNOS and the pro-inflammatory cytokine IL-6 associated with M1 macrophages and promotes the proliferation of cytotoxic CD8+ T cells. FGT-4 demonstrates antitumor activity in the 4T1 breast cancer mouse model and is applicable for cancer immunotherapy research.</p>Fórmula:C50H57N11O9S2Forma y color:SolidPeso molecular:1019.37821PROTAC IRAK4 degrader-4
CAS:<p>PROTAC IRAK4 degrader-4 is a targeted Cereblon-based molecule for degrading IRAK4.</p>Fórmula:C41H38F3N11O10Forma y color:SolidPeso molecular:901.817CD19 CAR circRNA
<p>CD19 CAR circRNA expresses a CD19 car protein for CAR-T immunotherapy targeting B-cell antigens.</p>Forma y color:SolidSiplizumab
CAS:<p>Siplizumab (MEDI-507), an IgG1 antibody targeting CD2, depletes T cells, may treat psoriasis.</p>Pureza:100% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:147.24 kDaPSB-24000
<p>PSB-24000 (Compound 27) is a selective ecto-5'-nucleotidase (CD73) inhibitor with a Ki value of 563 nM for inhibiting human CD73, and a Ki of 481 nM in membrane-bound CD73 in triple-negative breast cancer cells. It disrupts CD73’s recognition and action on substrate AMP, preventing AMP-induced immunosuppressive and pro-cancer adenosine production. PSB-24000 is promising for cancer research.</p>Forma y color:Odour Solid1-Ethoxycarbonyl-β-carboline
CAS:<p>1-Ethoxycarbonyl-β-carboline is a natural product for research related to life sciences. The catalog number is TN7072 and the CAS number is 72755-19-2.</p>Fórmula:C28H23N4O4Forma y color:SolidPeso molecular:479.516EG01377 2HCl
CAS:<p>EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377</p>Fórmula:C26H32Cl2N6O6S2Pureza:98.91%Forma y color:SoildPeso molecular:659.6Lintuzumab
CAS:Lintuzumab (HuM-195) is an uncoupled humanized mouse monoclonal antibody against CD33 with anti-leukemic activity.Pureza:98% (SDS-PAGE); 98.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.2% (SEC-HPLC)Forma y color:Liquid2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside
CAS:<p>2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside that is commonly found in the bulbs of</p>Fórmula:C20H27Cl3O12Forma y color:SolidPeso molecular:565.78Ginger extract
CAS:<p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>Forma y color:SolidDovanvetmab
CAS:<p>Dovanvetmab (ZTS-00521505) is an IgG1-κ monoclonal antibody that targets feline interleukin 31 (Felcat IL31), primarily produced in Chinese Hamster Ovary (CHO)</p>Forma y color:LiquidCarboxy-PTIO
CAS:<p>Carboxy-PTIO rapidly scavenges NO, forming NO2, key in preventing hypotension and shock in rats.</p>Fórmula:C14H17N2O4Forma y color:SolidPeso molecular:277.3Inflexuside B
CAS:<p>Inflexuside B, an abietane diterpenoid derived from the aerial parts of Isodon inflexus, effectively inhibits lipopolysaccharide (LPS)-activated NO Synthase in</p>Fórmula:C35H48O11Forma y color:SolidPeso molecular:644.75CD73-IN-17
<p>CD73-IN-17 (compound 19) is an inhibitor of CD73 with an IC50 of 0.1 μM against hCD73. It is applicable in cancer research.</p>Forma y color:Odour Solid2-Aminoquinoline
CAS:<p>Compound Fr16621, with CAS No. 580-22-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr16621 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C9H8N2Forma y color:Light Yellow CrystalsPeso molecular:144.18PMX 205 Trifluoroacetate
<p>PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.</p>Fórmula:C47H63F3N10O8Forma y color:SolidPeso molecular:953.06E7766 disodium
CAS:<p>E7766 disodium, a macrocycle-bridged STING agonist, exhibits a binding affinity (Kd) of 40 nM, demonstrating potent pan-genotypic and antitumor effects.</p>Fórmula:C24H26F2N10Na2O8P2S2Forma y color:SolidPeso molecular:792.58STING-IN-12
<p>STING-IN-12 (compound Y2) acts as an inhibitor of STING. It suppresses IFNβ gene expression induced by SR717 with an IC50 of 0.75 μM. Additionally, STING-IN-12 inhibits STING pathway activation induced by the STING agonist SR717 in THP1 cells and by MSA-2 in mice.</p>Forma y color:Odour SolidSTING agonist-17
CAS:<p>STING agonist-17 (compound 4a) is a highly potent stimulator of the STING pathway, exhibiting an IC 50 of 0.062 nM.</p>Fórmula:C43H53N13O8Forma y color:SolidPeso molecular:879.96Tetrachlorohydroquinone
CAS:<p>TCHQ, a pentachlorophenol metabolite, toxic to trout liver cells, increases ROS, disrupts mitochondria, and causes necrosis in splenocytes. EC50: 1.55 μM.</p>Fórmula:C6H2Cl4O2Forma y color:SolidPeso molecular:247.89Olendalizumab
CAS:<p>Olendalizumab (ALXN1007) is a humanized antibody targeting C5a for research on COVID-19-related inflammation.</p>Forma y color:LiquidAnticancer agent 15
CAS:<p>Anticancer agent 15 raises ROS, causing necroptosis in melanoma cells.</p>Fórmula:C35H40Cl2N2O5Forma y color:SolidPeso molecular:639.61CDN-A
CAS:<p>CDN-A, a cyclic di-nucleotide, activates immune response & aids in ADC synthesis.</p>Fórmula:C22H29N11O12P2Forma y color:SolidPeso molecular:701.48Ladanetin-6-O-β-D-glucopyranoside
CAS:<p>Ladanetin-6-O-β-D-glucopyranoside, an active flavonoid, exhibits antioxidative effects and has potential for research into cardioprotective effects [1].</p>Fórmula:C22H22O11Forma y color:SolidPeso molecular:462.4Mifamurtide sodium
CAS:<p>Mifamurtide sodium is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults. It was approved in Europe in March 2009.</p>Fórmula:C59H108N6NaO19PPureza:98%Forma y color:SolidPeso molecular:1259.48Isoxaben
CAS:<p>Isoxaben (EL 107) is a specific inhibitor of cell wall biosynthesis, often used as a herbicide, that inhibits the incorporation of radiolabeled glucose into</p>Fórmula:C18H24N2O4Pureza:98.84%Forma y color:SolidPeso molecular:332.39MJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Forma y color:Odour SolidNLRP3-IN-49
<p>NLRP3-IN-49 (compound Z48) is a potent and specific inhibitor of NLRP3, displaying IC50 values of 0.26 μM in THP-1 cells and 0.21 μM in mouse bone marrow-derived macrophages. It directly binds to the NLRP3 protein with a dissociation constant (Kd) of 1.05 μM, effectively preventing the assembly and activation of the NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 is utilized in the research of inflammatory bowel disease.</p>Forma y color:Odour SolidNOD1/2-IN-1
<p>NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor, demonstrating an IC50 value of 1.4 nM in the ADP-Glo assay. It blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathway (IC50 values are 18 nM and 170 nM for NOD1 and NOD2, respectively), thereby reducing inflammatory responses. This compound is utilized in research related to colitis.</p>Forma y color:Odour SolidC6 L-threo Ceramide (d18:1/6:0)
CAS:<p>C6 L-threo Ceramide: bioactive sphingolipid, cytotoxic to U937 cells (IC50=18μM), non-metabolic, boosts IL-4 in T cells at 10μM.</p>Fórmula:C24H47NO3Forma y color:SolidPeso molecular:397.63Hispaglabridin A
CAS:<p>Hispaglabridin A, an effective antioxidant, inhibits lipid peroxidation [1].</p>Fórmula:C25H28O4Forma y color:SolidPeso molecular:392.49Dalutrafusp alfa
CAS:<p>Dalutrafusp alfa (AGEN-1423; GS-1423) is a bifunctional antibody targeting CD73 and TGF-β, components of the immunosuppressive pathway [1].</p>Forma y color:LiquiddiABZI-4
CAS:<p>DiABZI-4 is an orally active STING agonist that exhibits broad-spectrum antiviral activity. It functions by activating STING to induce the production of pro-inflammatory cytokines and activation of lymphocytes. This action inhibits the replication of Influenza A virus (IAV), SARS-CoV-2, and Human Rhinovirus (HRV), with an EC50 range of 11.8-199 nM.</p>Fórmula:C40H51Cl2N13O6Forma y color:SolidPeso molecular:880.82NLRP3-IN-12
<p>NLRP3-IN-12 inhibits NLRP3 inflammasome, curbing IL-1β release with 0.45 μM IC50, for inflammatory bowel disease research.</p>Fórmula:C27H32ClNO7Forma y color:SolidPeso molecular:518Bavunalimab
CAS:<p>Bavunalimab: bispecific anti-CTLA-4/LAG-3 antibody, T-cell activator in NSG mice, for cancer research.</p>Forma y color:LiquidMipeginterferon alfa-2b
CAS:<p>Mipeginterferon alfa-2b, an IFNA2b analogue, has 5 modified amino groups out of 11 and weighs 40 kDa.</p>Forma y color:LiquidNF-κB-IN-9
<p>NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dual</p>Fórmula:C62H50N4O4SForma y color:SolidPeso molecular:947.15Goflikicept
CAS:<p>Goflikicept (RPH 104) binds/inactivates IL-1ß/α; may research STEMI.</p>Forma y color:LiquidSirtuin modulator 2
CAS:<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Fórmula:C19H15N3O2SPureza:99.67%Forma y color:SolidPeso molecular:349.41NLRP3-IN-75
<p>NLRP3-IN-75 is an orally effective inhibitor of NLRP3, capable of suppressing IL-1β secretion with an IC50 of 23 nM. It selectively inhibits NLRP3 activation by disrupting inflammasome assembly without affecting the assembly of NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 demonstrates excellent anti-inflammatory effects in models of acute peritonitis, diabetic nephropathy, and inflammatory bowel disease (IBD).</p>Forma y color:Odour SolidIL-1β-IN-1
CAS:<p>IL-1β-IN-1, a cannabidiol derivative, acts as a potent inhibitor of IL-1β, exhibiting significant anti-inflammatory and pain relief properties [1].</p>Fórmula:C22H34O2Forma y color:SolidPeso molecular:330.5ADP-β-S trisodium
<p>ADP-β-S (trisodium) is an analog of ADP and acts as a partial agonist. It can induce human platelet aggregation and inhibit PGE1-stimulated adenylate cyclase.</p>Fórmula:C10H12N5Na3O9P2SForma y color:SolidPeso molecular:508.95241Butan-1-amine hydrochloride
CAS:<p>1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).</p>Fórmula:C4H12ClNForma y color:SolidPeso molecular:109.6Hydroxychloroquine Impurity E
CAS:<p>Hydroxychloroquine Impurity E, a byproduct, can block TLR7/9 and inhibit SARS-CoV-2 in vitro.</p>Fórmula:C14H17ClN2OForma y color:SolidPeso molecular:264.75ODN D-SL03
CAS:<p>ODN D-SL03, a C class CpG oligonucleotide, stimulates PBMCs, activating B cells, NK cells & monocytes, and can inhibit tumor growth.</p>Forma y color:SolidPeso molecular:9345Melredableukin alfa
CAS:<p>Melredableukin alfa, a human IgG1-κ fused with IL2 mutein, is studied for autoimmune hepatitis and ulcerative colitis.</p>Forma y color:LiquidObinutuzumab
CAS:<p>Obinutuzumab (Obinutuzumab/afutuzumab) GA101) is a glycoengineered Type II CD20 monoclonal antibody in development for non-Hodgkin lymphoma.</p>Pureza:98.00% - 98.9% (SDS-PAGE); 99.4% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.6 kDaBMS-986179
<p>BMS-986179 is a human monoclonal antibody targeting NT5E/CD73. It inhibits CD73 enzymatic activity both in tumor vasculature and tumor cells. BMS-986179 is applicable for research in advanced solid tumors.</p>Forma y color:Odour LiquidAMY-101
CAS:<p>AMY-101 TFA is a C3 complement inhibitor with high affinity (KD: 0.5 nM) and promising anti-inflammatory effects in severe COVID-19.</p>Fórmula:C83H117N23O18S2Pureza:98%Forma y color:SolidPeso molecular:1789.11PSMA-IN-3
<p>PSMA-IN-3 (compound 17) is a novel, high-affinity inhibitor of Prostate-Specific Membrane Antigen (PSMA) with an inhibitory concentration (IC50) of 13 nM,</p>Fórmula:C43H50FN7O15Forma y color:SolidPeso molecular:923.898-Nitroguanine
CAS:<p>8-Nitroguanine is a product of DNA nitration damage caused by reactive nitrogen species and may be a potential biomarker for the progression of malignant</p>Fórmula:C5H4N6O3Forma y color:SolidPeso molecular:196.12NLRP3-IN-48
<p>NLRP3-IN-48 is an inhibitor of NLRP3. It suppresses the activation of the NLRP3 inflammasome by targeting the NLRP3 protein, thereby interfering with the assembly of the NLRP3 inflammasome. Additionally, NLRP3-IN-48 exhibits anti-inflammatory activity in a DSS-induced acute colitis model in mice.</p>Forma y color:Odour SolidRIPK1-IN-25
<p>RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.</p>Forma y color:Odour SolidBI1543673
<p>BI1543673 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). It can diminish inflammatory responses in human lung tissue stimulated by TLR4 and TLR7/8. Additionally, BI1543673 reduces inflammatory signaling in a mouse lung inflammation model induced by LPS.</p>Forma y color:Odour SolidGSK2831781
<p>GSK2831781 is a human IgG1 monoclonal antibody (mAb) designed to target CD223/LAG3. This compound is applicable in research studies focused on ulcerative colitis. For experimental controls, the recommended isotype control is Human IgG1 kappa.</p>Forma y color:Odour LiquidKTX-612
CAS:<p>KTX-612 is a compound that serves as an orally active IRAK4 degrader, exhibiting a DC50 value of 7 nM. It is primarily utilized in oncology research [1].</p>Fórmula:C46H51F3N8O6Forma y color:SolidPeso molecular:868.94Eritoran Tetrasodium
CAS:<p>Eritoran Tetrasodium, a TLR4 receptor antagonist, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C66H122N2Na4O19P2Pureza:98%Forma y color:SolidPeso molecular:1401.58NLRP3-IN-51
<p>NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.</p>Forma y color:Odour SolidPNT2001
CAS:<p>PNT2001 (LY4181530) is an effective prostate-specific membrane antigen (PSMA) ligand with an IC50 of 3.1 nM. It enhances cellular internalization and, when labeled with 177Lu and 225Ac, is applicable for prostate cancer research.</p>Fórmula:C85H107N15O32Forma y color:SolidPeso molecular:1850.84PS 1145 dihydrochloride
CAS:<p>IκB kinase (IKK) inhibitor</p>Fórmula:C17H13Cl3N4OPureza:98%Forma y color:SolidPeso molecular:395.67Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH
<p>Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH, a linker with TLR4-IN-C34, reduces inflammation in mice.</p>Fórmula:C78H125N7O36Forma y color:SolidPeso molecular:1736.85Bectumomab
CAS:<p>Bectumomab (IMMU-LL2) is a humanized IgG2a mAb targeting CD22, used in imaging and staging non-Hodgkin's lymphoma.</p>Forma y color:LiquidSacituzumab MMAE
<p>Sacituzumab-MMAE (CHB295) Anti-TROP2 Reference Antibody is produced in CHO cells and consists of a huIgG1 heavy chain and a hukappa light chain. This compound has a predicted molecular weight (MW) of 146.06 kDa.</p>Forma y color:LiquidPeso molecular:150 kDaTBK1/IKKε-IN-6
CAS:<p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>Fórmula:C31H36F2N8O4Forma y color:SolidPeso molecular:622.678MTvkPABC-P5 TFA
<p>MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).</p>Forma y color:Odour SolidDamnacanthol
<p>Damnacanthol is a useful organic compound for research related to life sciences and the catalog number is T131609.</p>Fórmula:C16H12O5Forma y color:SolidPeso molecular:284.267PSMA-DA1
CAS:PSMA–DA1 may be a useful PSMA-targeting radiotheranostic agent.Fórmula:C50H76IN9O20Forma y color:SolidPeso molecular:1250.105Efmarodocokin alfa
CAS:<p>Efmarodocokin alfa, IL-22/IgG4 fusion protein, activates IL-22 pathways, researched for severe COVID-19 pneumonia.</p>Forma y color:LiquidEnglumafusp alfa
<p>Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion protein combining a CD19-specific antibody domain with trimerized extracellular domains of human 4-1BBL,</p>Forma y color:Odour LiquidUbletamig
CAS:<p>Ubletamig is a humanized IgG4κ monoclonal antibody that targets MUC16.</p>Forma y color:LiquidMifamurtide TFA
<p>Mifamurtide TFA: muramyl dipeptide analog, boosts immunity, activates macrophages/monocytes, potential osteosarcoma research.</p>Fórmula:C61H110F3N6O21PForma y color:SolidPeso molecular:1351.52Vemircopan
CAS:<p>Vemircopan is a complement factor D inhibitor.</p>Fórmula:C29H28BrN7O3Forma y color:SolidPeso molecular:602.493Dazostinag
CAS:<p>Dazostinag (TAK-676) is a STING agonist with anti-cancer properties, used in making ADCs.</p>Fórmula:C21H22F2N8O10P2S2Forma y color:SolidPeso molecular:710.52BTH1704
<p>BTH1704 is a human monoclonal antibody targeting MUC1. It facilitates the killing of iC3b-opsonized tumor cells by leukocytes triggered by PGG. BTH1704 is applicable in studies on pancreatic cancer and breast cancer.</p>Forma y color:Odour LiquidNLRP3-IN-46
<p>NLRP3-IN-46 (Compound 3k) activates the cholinergic anti-inflammatory pathway involved in neuro-immune modulation, thereby inhibiting the activation of the NLRP3 inflammasome. Furthermore, NLRP3-IN-46 suppresses the production of IL-1β in THP-1 cells induced by Uric acid sodium, making it relevant for research in gouty arthritis.</p>Forma y color:Odour SolidCD73-IN-16
<p>CD73-IN-16 (compound 18) acts as an inhibitor of hCD73, exhibiting an IC50 value of 0.28 μM.</p>Forma y color:Odour SolidNrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Fórmula:C27H26N2O6Forma y color:SolidPeso molecular:474.51IFN-α Receptor Recognition Peptide 1
CAS:<p>IFN-α Receptor Recognition Peptide 1, associated with receptor interactions, is a peptide of IFN-α.</p>Fórmula:C35H59N13O12SPureza:98%Forma y color:SolidPeso molecular:885.99Murrayafoline A
CAS:<p>Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.</p>Fórmula:C14H13NOForma y color:SolidPeso molecular:211.264SU1261
<p>SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.</p>Forma y color:Odour SolidNLRP3-IN-74
<p>NLRP3-IN-74 (Compound 11) is an orally active NLRP3 inhibitor with an IC50 of 2.7 μM. It significantly reduces IL-1β release by approximately 90% without affecting TNFα release. NLRP3-IN-74 is applicable in research on diseases such as atherosclerosis and Parkinson's disease.</p>Forma y color:Odour SolidTri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH
<p>Tri(TLR4-IN-C34-PEG2/PEG1)-amide-C3-COOH is a TLR4 inhibiting linker, reducing inflammation in endotoxemia and enterocolitis mouse models.</p>Fórmula:C78H125N7O42Forma y color:SolidPeso molecular:1832.85COX-2-IN-48
<p>COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.</p>Forma y color:Odour SolidPegaldesleukin
CAS:<p>Pegaldesleukin, a PEG-IL2 conjugate, exhibits antiviral properties, potentially slowing HIV progression, preserving immune function.</p>Forma y color:LiquidSTING agonist-28
CAS:<p>STING agonist-28 (CF510), a non-nucleotide, boosts STING, TBK1, IRF3 phosphorylation, and cytokines; active against SARS-CoV.</p>Fórmula:C39H46N14O6Forma y color:SolidPeso molecular:806.87Eramkafusp Alfa
<p>Eramkafusp alfa is a human IgG1 antibody that targets the murine B lymphocyte antigen CD20, also known as MS4A1 [1].</p>Forma y color:Odour LiquidNurulimab
CAS:<p>Nurulimab (BCD-145) is an anti-CTLA-4 antibody with anti-cancer activity for the study of skin and musculoskeletal diseases.</p>Pureza:95.5% (SDS-PAGE); 97.3% (SEC-HPLC) - 95.5% (SDS-PAGE); 97.3% (SEC-HPLC)Forma y color:LiquidHPPD-IN-1
<p>HPPD-IN-1 (compound II-3), a potent HPPD inhibitor, exhibits inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) with an IC50 of 0.248 μM, surpassing</p>Fórmula:C12H6F3NO4Forma y color:SolidPeso molecular:285.18IACS-8803 diammonium
<p>IACS-8803 diammonium, a potent cyclic dinucleotide STING agonist, demonstrates robust systemic antitumor efficacy [1].</p>Fórmula:C20H29FN12O9P2S2Forma y color:SolidPeso molecular:726.6
