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Inmunología e inflamación

Inmunología e inflamación

Los inhibidores de inmunología e inflamación son compuestos que modulan la respuesta inmunitaria y los procesos inflamatorios. Estos inhibidores son cruciales para estudiar los mecanismos de regulación inmunitaria, la autoinmunidad y la inflamación crónica, así como para desarrollar tratamientos para enfermedades inflamatorias, alergias y trastornos relacionados con el sistema inmunológico. Al dirigirse a vías clave en el sistema inmunológico, estos inhibidores pueden ayudar a reducir las respuestas inmunitarias excesivas o inadecuadas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.

Subcategorías de "Inmunología e inflamación"

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Se han encontrado 3045 productos de "Inmunología e inflamación"

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  • 6,2′,4′-Trimethoxyflavone
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    6,2′,4′-Trimethoxyflavone

    CAS:
    <p>6,2′,4′-Trimethoxyflavone is an AhR antagonist that does not demonstrate effective protection against ischemia-reperfusion injury in the brain of Sprague-Dawley rats.</p>
    Fórmula:C18H18O5
    Forma y color:Solid
    Peso molecular:314.332

    Ref: TM-T206907

  • IRAK1/4/pan-FLT3 Kinase-IN-2
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    IRAK1/4/pan-FLT3 Kinase-IN-2

    CAS:
    <p>IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and &lt; 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.</p>
    Fórmula:C20H22F3N5O
    Forma y color:Solid
    Peso molecular:405.42

    Ref: TM-T207286

  • A-9758
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    A-9758

    CAS:
    <p>A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.</p>
    Fórmula:C25H23Cl2F3N2O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:527.36

    Ref: TM-T10210

  • PB01
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    PB01

    CAS:
    <p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>
    Fórmula:C18H21N5O3
    Forma y color:Solid
    Peso molecular:355.391

    Ref: TM-T204296

  • Hypoxystat
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    Hypoxystat

    CAS:
    <p>Hypoxystat increases the affinity of hemoglobin for oxygen, thereby reducing the release of oxygen to tissues and inducing tissue hypoxia. [Hypoxystat] can alleviate mitochondrial disorder Leigh syndrome in Ndufs4 gene knockout mouse models. Hypoxystat is orally active.</p>
    Fórmula:C21H21NO5
    Forma y color:Solid
    Peso molecular:367.395

    Ref: TM-T205665

  • Keap1-Nrf2-IN-5
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    Keap1-Nrf2-IN-5

    CAS:
    <p>Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).</p>
    Fórmula:C23H30N4O6S
    Forma y color:Solid
    Peso molecular:490.57

    Ref: TM-T63294

  • Logo de CymitQuimica
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    COX-2/NO-IN-1

    <p>COX-2/NO-IN-1: oral iNOS &amp; NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>
    Fórmula:C15H15NO3
    Forma y color:Solid
    Peso molecular:257.28

    Ref: TM-T60403

  • Methoxyurea
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    Methoxyurea

    CAS:
    <p>Methoxyurea (Compound 3) is a potential modulator of nitric oxide (NO) donors, interacting with hemoglobin forms such as oxyhemoglobin (OxyHb) and methemoglobin (MetHb). It holds promise for use in research on sickle cell disease (SCD).</p>
    Fórmula:C2H6N2O2
    Forma y color:Solid
    Peso molecular:90.081

    Ref: TM-T206073

  • Logo de CymitQuimica
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    CD73-IN-12

    <p>CD73-IN-12, a compound from CN114437038A, shows strong anti-tumor activity by effectively inhibiting CD73 enzyme.</p>
    Fórmula:C17H14F2N4O2
    Forma y color:Solid
    Peso molecular:344.32

    Ref: TM-T61118

  • AMC-04
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    AMC-04

    CAS:
    <p>AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].</p>
    Fórmula:C26H28N2O3
    Forma y color:Solid
    Peso molecular:416.51

    Ref: TM-T85643

  • HG-12-6
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    HG-12-6

    CAS:
    <p>HG-12-6 is a type II IRAK4 inhibitor, targeting its inactive form with an IC50 of 165 nM, and is used in autoimmunity and inflammation.</p>
    Fórmula:C29H27F3N6O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:580.62

    Ref: TM-T11559

  • STING-IN-11
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    STING-IN-11

    CAS:
    <p>STING-IN-11 (Compound 42) is an orally active STING inhibitor with an IC50 of 37.8 nM. It impedes palmitoylation of the STING protein and the downstream signaling of STING, thereby inhibiting STING-mediated inflammation. STING-IN-11 demonstrates good in vivo safety and can be utilized for research on STING-related inflammatory and autoimmune diseases.</p>
    Fórmula:C21H20ClF2N3O
    Forma y color:Solid
    Peso molecular:403.853

    Ref: TM-T205702

  • (S)-MALT1-IN-5
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    (S)-MALT1-IN-5

    CAS:
    <p>(S)-MALT1-IN-5: Potent MALT1 protease inhibitor, may help in abnormal T/B-cell signalling and MALT1-linked diseases.</p>
    Fórmula:C17H17ClF2N6O3
    Forma y color:Solid
    Peso molecular:426.80

    Ref: TM-T62322

  • Logo de CymitQuimica
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    ABZI

    CAS:
    <p>(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.</p>
    Fórmula:C23H24N6O3
    Peso molecular:432.48

    Ref: TM-T207188

  • IRAK4-IN-30
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    IRAK4-IN-30

    CAS:
    <p>IRAK4-IN-30 (Compound I) is an inhibitor of IRAK4, with an IC50 of 0.6 nM.</p>
    Fórmula:C27H33N5O5
    Forma y color:Solid
    Peso molecular:507.581

    Ref: TM-T205748

  • Logo de CymitQuimica
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    Galectin-8-IN-1

    <p>Galectin-8-IN-1 selectively binds galectin-8N with 48 μM affinity, 15x more than galectin-3.</p>
    Fórmula:C16H18N2O6
    Forma y color:Solid
    Peso molecular:334.32

    Ref: TM-T61014

  • NOTA-FAPI
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    NOTA-FAPI

    CAS:
    <p>NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.</p>
    Fórmula:C36H47F2N9O8
    Pureza:99.748%
    Forma y color:Solid
    Peso molecular:771.81

    Ref: TM-T69660

  • COX-2/15-LOX-IN-5
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    COX-2/15-LOX-IN-5

    CAS:
    <p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>
    Fórmula:C25H21N3O3S
    Forma y color:Solid
    Peso molecular:443.52

    Ref: TM-T86081

  • AM679
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    AM679

    CAS:
    <p>AM679: potent, selective FLAP inhibitor; IC50s—2.2 nM (FLAP), 0.6 nM (hLA), 154 nM (hWB); blocks leukotrienes in vivo; no significant CYP3A4 interaction.</p>
    Fórmula:C40H44N4O5S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:692.87

    Ref: TM-T14205

  • RIPK1-IN-19
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    RIPK1-IN-19

    CAS:
    <p>RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.</p>
    Fórmula:C28H25FN6O2
    Pureza:98.81%
    Forma y color:Solid
    Peso molecular:496.54

    Ref: TM-T87334