Inmunología e inflamación
Los inhibidores de inmunología e inflamación son compuestos que modulan la respuesta inmunitaria y los procesos inflamatorios. Estos inhibidores son cruciales para estudiar los mecanismos de regulación inmunitaria, la autoinmunidad y la inflamación crónica, así como para desarrollar tratamientos para enfermedades inflamatorias, alergias y trastornos relacionados con el sistema inmunológico. Al dirigirse a vías clave en el sistema inmunológico, estos inhibidores pueden ayudar a reducir las respuestas inmunitarias excesivas o inadecuadas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Subcategorías de "Inmunología e inflamación"
- CCR(136 productos)
- CXCR(148 productos)
- Pared celular(5 productos)
- Receptor de IL(112 productos)
- IκB / IKK(60 productos)
- LTR(3 productos)
- MALT(23 productos)
- MRP(6 productos)
- NADPH-oxidasa(1 productos)
- NF-κB(444 productos)
- NOD(17 productos)
- NOS(63 productos)
- Nrf2(79 productos)
- PGE sintasa(31 productos)
- ROS(69 productos)
- TGF-beta / Smad(58 productos)
- TLR(66 productos)
- Tiorredoxina(12 productos)
- gp120 / CD4(4 productos)
Mostrar 11 subcategorías más
Se han encontrado 3045 productos de "Inmunología e inflamación"
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NLRP3-IN-58
CAS:<p>NLRP3-IN-58 (Compound DS15) acts as an inhibitor of NLRP3 inflammasome activation, with an IC50 value of 3.85 μM, and is capable of inhibiting 33% of IL-1β release at a concentration of 10 μM.</p>Fórmula:C22H18ClN3O3SForma y color:SolidPeso molecular:439.92STING agonist-42
CAS:<p>STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.</p>Fórmula:C17H8F2LiN5O3Forma y color:SolidPeso molecular:375.22NLRP3-IN-70
CAS:<p>NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.</p>Fórmula:C23H23NO5Forma y color:SolidPeso molecular:393.432MG-T-19
CAS:<p>MG-T-19, a TIM-3 inhibitor, inhibit the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs.</p>Fórmula:C18H8Br2ClF3N4O2SPureza:99.14%Forma y color:SolidPeso molecular:596.6STING-IN-15
CAS:<p>STING-IN-15 (compound 66) is a potent STING inhibitor, effectively suppressing human and mouse STING with IC50 values of 116 nM and 96.3 nM, respectively. In the REX1 D18N mouse model, STING-IN-15 significantly reduces tissue damage and inflammation.</p>Fórmula:C20H14F2N4O3Forma y color:SolidPeso molecular:396.35NLRP3-IN-80
CAS:<p>NLRP3-IN-80 (Compound 1) is an NLRP3 inhibitor useful for research into inflammatory aging.</p>Fórmula:C24H22F2N4O3Forma y color:SolidPeso molecular:452.45NP3-146 sodium
CAS:<p>NP3-146 sodium is an inhibitor of the NLRP3 inflammasome.</p>Fórmula:C20H26ClN2NaO5SForma y color:SolidPeso molecular:464.94AS2690168 hydrochloride
CAS:<p>AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Fórmula:C17H15Cl2F3N4OForma y color:SolidPeso molecular:419.228mPGES1-IN-9
CAS:<p>mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.</p>Fórmula:C25H18N4OSForma y color:SolidPeso molecular:422.502FK-565
CAS:<p>FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.</p>Fórmula:C22H38N4O9Forma y color:SolidPeso molecular:502.559AS2690168 (free base)
CAS:<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Fórmula:C17H13F3N4OForma y color:SolidPeso molecular:346.306(Rel)-Factor B-IN-5
CAS:<p>(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.</p>Fórmula:C27H32N2O4Pureza:>99.99%Forma y color:SolidPeso molecular:448.55CD73-IN-19
CAS:<p>CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.</p>Fórmula:C18H17N3O3SForma y color:SolidPeso molecular:355.411LHC-165
CAS:<p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>Fórmula:C29H32F2N3O7PPureza:98%Forma y color:SolidPeso molecular:603.55G108
CAS:<p>G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.</p>Fórmula:C16H14Cl2N4O2Pureza:99.13% - 99.75%Forma y color:SolidPeso molecular:365.21SP4206
CAS:<p>SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)</p>Fórmula:C30H37Cl2N7O6Pureza:98%Forma y color:SolidPeso molecular:662.56oxLig-1
CAS:<p>OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).</p>Fórmula:C36H58O5Forma y color:SolidPeso molecular:570.84Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Fórmula:C22H20O12Forma y color:SolidPeso molecular:476.39OP-5244 sodium
<p>OP-5244 sodium: potent oral CD73 inhibitor (IC50: 0.25 nM), potential in cancer research by hindering adenosine, reversing immunosuppression.</p>Fórmula:C19H28ClN5NaO9PForma y color:SolidPeso molecular:559.87RGT-068A
CAS:<p>RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .</p>Fórmula:C17H16ClN9O2Forma y color:SolidPeso molecular:413.82COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Fórmula:C25H23N5O4S2Forma y color:SolidPeso molecular:521.61C5aR-IN-3
CAS:<p>C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.</p>Fórmula:C36H40FN5O3Forma y color:SolidPeso molecular:609.73Nrf2 activator-6
CAS:<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Fórmula:C31H37ClFN5O5Forma y color:SolidPeso molecular:614.11AIM4
CAS:<p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>Fórmula:C25H23Br2N5O4Forma y color:SolidPeso molecular:617.289TLR7/8 antagonist 1
<p>Compound 16c, an imidazoquinoline, is a TLR7/8 agonist; IC50: 3.91 μM (TLR7), 2.19 μM (TLR8); targets TLR-2050 for disease treatment.</p>Fórmula:C24H27N5O2Forma y color:SolidPeso molecular:417.5SARM1-IN-4
CAS:<p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>Fórmula:C13H17F2N3O2Forma y color:SolidPeso molecular:285.29COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Fórmula:C19H14ClN5S2Forma y color:SolidPeso molecular:411.93STING agonist-20
CAS:<p>STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.</p>Fórmula:C36H39N11O8Forma y color:SolidPeso molecular:753.76Antioxidant agent-3
<p>Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.</p>Fórmula:C18H14O8Forma y color:SolidPeso molecular:358.3NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Fórmula:C18H15ClN2O4S3Forma y color:SolidPeso molecular:454.97SMW139
CAS:<p>SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.</p>Fórmula:C19H21ClF3NO2Forma y color:SolidPeso molecular:387.824COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Fórmula:C15H10ClIN2OForma y color:SolidPeso molecular:396.61CPDT
CAS:<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Fórmula:C6H6S3Forma y color:SolidPeso molecular:174.307Gardiquimod hydrochloride
CAS:<p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>Fórmula:C17H24ClN5OForma y color:SolidPeso molecular:349.858IACS-8779 disodium
CAS:<p>IACS-8779 disodium: potent STING agonist, strong systemic anti-tumor effects, effective in melanoma model.</p>Fórmula:C21H23N9Na2O10P2S2Forma y color:SolidPeso molecular:733.52COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Fórmula:C22H23FN2O6S2Forma y color:SolidPeso molecular:494.56IL-17 modulator 1 disodium
CAS:<p>Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.</p>Fórmula:C28H37N6NaO6PForma y color:SolidPeso molecular:607.604TIM-3-IN-1
<p>TIM-3-IN-1 is a useful tool to enable further studies on the biology of TIM-3 immunoregulation in cancer.</p>Fórmula:C20H16ClN7O3SForma y color:SolidPeso molecular:469.9MSA-2 dimer
CAS:<p>MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.</p>Fórmula:C29H28O8S2Forma y color:SolidPeso molecular:568.66Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Fórmula:C18H15N5O2SForma y color:SolidPeso molecular:365.41IKZF2-degrader 1
CAS:<p>IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.</p>Fórmula:C27H30FN7O3Forma y color:SolidPeso molecular:519.57Balsalazide disodium
CAS:<p>Balsalazide disodium is an aminosalicylate prodrug that releases mesalamine in the colon, providing diverse anti-inflammatory effects in regions affected by colitis. Additionally, it exhibits anticancer properties by modulating the IL-6/STAT3 pathway.</p>Fórmula:C17H13N3Na2O6Forma y color:SolidPeso molecular:401.281C-di-IMP
CAS:<p>Cyclic-di-IMP (C-di-IMP), a STING agonist, serves as a research tool in tumor studies.</p>Fórmula:C20H22N8O14P2Forma y color:SolidPeso molecular:660.386-Alkyne-F-araNAD
CAS:<p>6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).</p>Fórmula:C24H28FN7O13P2Forma y color:SolidPeso molecular:703.464MMG-11 quarterhydrate
<p>MMG-11 quarterhydrate, a potent hTLR2 antagonist, inhibits TLR2/1 and TLR2/6 with IC50s of 1.7μM and 5.7μM; low toxicity.</p>Fórmula:C15H16O8Forma y color:SolidPeso molecular:310.78Polvitolimod
CAS:<p>Polvitolimod is a TLR7 agonist used to treat infectious disease and cancer.</p>Fórmula:C13H14FN5O4Forma y color:SolidPeso molecular:323.28NF-κB-IN-6
<p>NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signaling</p>Fórmula:C14H20N2O3Forma y color:SolidPeso molecular:264.32IRAK4 ligand-13
CAS:<p>IRAK4ligand-13 is an IRAK4 ligand and serves as a PROTAC target protein ligand. It is utilized in the synthesis of PROTAC compounds, such as LZ-07.</p>Fórmula:C23H26N10Forma y color:SolidPeso molecular:442.52BAA473
<p>BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.</p>Fórmula:C36H62O5Pureza:98%Forma y color:SolidPeso molecular:574.87Fexlamose
CAS:<p>Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).</p>Fórmula:C12H22O9S2Forma y color:SolidPeso molecular:374.428TLR7/8 antagonist 2
<p>TLR7/8 antagonist 2: potent, orally active, IC50: 4.9 nM (TLR7), 0.6 nM (TLR8); potential for lupus therapy research.</p>Fórmula:C22H26FN5Forma y color:SolidPeso molecular:379.47IRAK4-IN-11
<p>IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1].</p>Fórmula:C16H19N7OForma y color:SolidPeso molecular:325.37IACS-8779
CAS:<p>IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.</p>Fórmula:C21H25N9O10P2S2Pureza:98%Forma y color:SolidPeso molecular:689.55NLRP3-IN-4
<p>NLRP3-IN-4 is an effective, oral NLRP3 inflammasome inhibitor with potent anti-inflammatory effects on colitis.</p>Fórmula:C22H22N2O5Forma y color:SolidPeso molecular:394.42IL-17 modulator 5
CAS:<p>IL-17 modulator 5 is a IL-17 inhibitor, with an IC 50 of 1 nM .</p>Fórmula:C28H23F6N9O2Forma y color:SolidPeso molecular:631.53(S,R,S)-AHPC-Boc derivative 1
CAS:<p>(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).</p>Fórmula:C28H40N4O6SForma y color:SolidPeso molecular:560.705K-14585
CAS:<p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>Fórmula:C51H56Cl2N8O4Forma y color:SolidPeso molecular:915.95Nrf2 activator-2
<p>Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.</p>Fórmula:C20H17BrO3Forma y color:SolidPeso molecular:385.25Nitric oxide production-IN-2
CAS:<p>TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.</p>Fórmula:C23H20O3Forma y color:SolidPeso molecular:344.403TLR7/8 agonist 7
CAS:<p>TLR7/8 agonist 7 activates immune cells, useful in ISAC synthesis and immunity research.</p>Fórmula:C26H37N7O2Forma y color:SolidPeso molecular:479.62GNE-2256
CAS:<p>GNE-2256, also known as molecule 19, is an orally active compound that inhibits Interleukin 1 receptor-associated kinase 4 (IRAK4) with a K i of 1.4 nM and has</p>Fórmula:C24H27FN6O4Forma y color:SolidPeso molecular:482.51MAO-B-IN-7
<p>MAO-B-IN-7 inhibits MAO-B/AChE, crossing the blood-brain barrier; IC50: 41/87 nM (h/eel AChE), 0.3 μM (MAO-B). Reduces oxidative stress and neuroinflammation.</p>Fórmula:C25H31NO4Forma y color:SolidPeso molecular:409.52ODN 21158
CAS:<p>ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.</p>Forma y color:SolidIRAK4-IN-14
CAS:<p>IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.</p>Fórmula:C25H28FN9OForma y color:SolidPeso molecular:489.55ROS inducer 9
CAS:<p>ROS inducer 9 (compound 4e) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Escherichia coli. It eradicates bacteria by inhibiting GSH activity and increasing ROS levels. Additionally, ROS inducer 9 exhibits low toxicity toward red blood cells and RAW 264.7 cells.</p>Fórmula:C26H26BrF4N3O3Forma y color:SolidPeso molecular:584.401CVN293
CAS:<p>CVN293 is a inhibitor of the potassium channel KCNK13,BBB,It inhibits the production of the pro-inflammatory cytokine IL-1β induced by NLRP3 in microglia</p>Fórmula:C14H10FN7OPureza:99.50%Forma y color:SolidPeso molecular:311.27Heme Oxygenase-1-IN-2
<p>Heme Oxygenase-1-IN-2 is a novel inhibitor of heme oxygenase-1 (HO-1), displaying potent antiproliferative activity in vitro, with an IC50 value of 0.95 μM.</p>Fórmula:C19H18ClN3OForma y color:SolidPeso molecular:339.82CD73-IN-13
<p>CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.</p>Fórmula:C13H11F3N4O2Forma y color:SolidPeso molecular:312.25Anti-inflammatory agent 102
CAS:<p>Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).</p>Fórmula:C16H16ClN3O3Forma y color:SolidPeso molecular:333.77MALT1-IN-5
CAS:<p>MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.</p>Fórmula:C17H17ClF2N6O3Forma y color:SolidPeso molecular:426.80Itaconic acid prodrug-1
CAS:<p>Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.</p>Fórmula:C15H22O10Forma y color:SolidPeso molecular:362.329COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Fórmula:C17H19NO3Forma y color:SolidPeso molecular:285.34ODN 2088
CAS:<p>ODN 2088 is a potent inhibitor of TLR3, TLR7 and TLR9 that is non-cytotoxic and shows inhibition of the release of IFN-α and IL-6.</p>Forma y color:SolidCorannulene
CAS:<p>Corannulene is an agonist of the aromatic hydrocarbon receptor (AhR). It induces a lower cytotoxic response in liver cancer cells compared to Benzo[a]pyrene and shows potential for use in cancer research.</p>Fórmula:C20H10Forma y color:SolidPeso molecular:250.293MAY0132
CAS:<p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>Fórmula:C16H15ClF3NForma y color:SolidPeso molecular:313.7452-Guanidinobezimidazole
CAS:<p>2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB).</p>Fórmula:C8H9N5Forma y color:SolidPeso molecular:175.191TLR7 agonist 28
CAS:<p>TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.</p>Fórmula:C26H25N9O7Forma y color:SolidPeso molecular:575.533iNOs-IN-1
<p>iNOs-IN-1 (YPW) is a strong iNOS inhibitor with dose-dependent anti-inflammatory properties, reducing IL-6, iNOS, and NO levels.</p>Fórmula:C25H30N4O5Forma y color:SolidPeso molecular:466.53NDT-30805
<p>NDT-30805, a triazolopyridine, blocks IL-1β in PBMC (IC50: 0.013μM) & NLRP3 inflammasome, for inflammation research.</p>Fórmula:C23H22N6SForma y color:SolidPeso molecular:414.53BMS-986458
CAS:<p>BMS-986458 is a highly selective, orally active BCL6 PROTAC degrader. It specifically targets cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity-induced BCL6 degradation. BMS-986458 is applicable for research in B-cell non-Hodgkin lymphoma.</p>Fórmula:C32H34ClN9O3Forma y color:SolidPeso molecular:628.124NLRP3-IN-8
CAS:<p>NLRP3-IN-8, orally active inflammasome blocker, IC50 of 1.23μM, stable (t1/2 = 138.63min), non-toxic (IC50 >100μM).</p>Fórmula:C23H20N2O6Forma y color:SolidPeso molecular:420.41AMS-17
<p>AMS-17, a strong NLRP3 inhibitor, quells microglia activation and cytokines like caspase-1, TNF-α, IL-1β, iNOS in studies.</p>Fórmula:C15H13F3N4O3SForma y color:SolidPeso molecular:386.35HPK1-IN-56
CAS:<p>HPK1-IN-56 (Compound A29) is an HPK1 inhibitor with an IC50 of 2.70 nM. It inhibits downstream p-SLP76 in Jurkat T cells with an IC50 of 8.1 nM. Additionally, HPK1-IN-56 induces IL-2 production in human PBMCs. This compound exhibits anticancer properties, enhancing T cell cytotoxicity and the antitumor efficacy of anti-PD-1 antibodies.</p>Fórmula:C24H26N8OForma y color:SolidPeso molecular:442.516mPGES-1-IN-1
<p>MPGES-1, potential anti-inflammatory drug target, has IC50 of 0.03 μM with mPGES-1-IN-1.</p>Fórmula:C21H14N4O2SForma y color:SolidPeso molecular:386.43COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Fórmula:C19H18N2O5SForma y color:SolidPeso molecular:386.42COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Fórmula:C19H19N3O4S2Forma y color:SolidPeso molecular:417.5SP11
CAS:<p>SP11 is a mitochondrial reactive oxygen species (ROS) inhibitor. It activates Fis1 with an IC50 of 9.4 µM by binding to Cys41 and enhances the translocation of Drp1 to mitochondria. SP11 is utilized for research into oxidative stress damage.</p>Fórmula:C18H19ClN2OSForma y color:SolidPeso molecular:346.87Ambuic acid
CAS:<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Fórmula:C19H26O6Forma y color:SolidPeso molecular:350.41COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Fórmula:C31H32FN5O2SForma y color:SolidPeso molecular:557.68Galectin-3-IN-2
<p>Galectin-3-IN-2 inhibits galactose lectin-3 (Gal-3) with an 8.3 μM IC50, impacting cancer-related metabolism.</p>Fórmula:C24H30FN3O10SForma y color:SolidPeso molecular:571.57ZM514
<p>ZM514 inhibits CD73 (hCD73 IC50: 1.39 μM, mCD73 IC50: 14.65 μM) with low cytotoxicity, suitable for cancer research.</p>Fórmula:C36H57NO4Forma y color:SolidPeso molecular:567.84IRAK4-IN-18
<p>IRAK4-IN-18: Potent IRAK4 inhibitor (IC50: 15 nM), reduces IL23 in cells, prevents rat arthritis.</p>Fórmula:C24H25FN6O3Forma y color:SolidPeso molecular:464.49DBMB
CAS:<p>DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.</p>Fórmula:C24H22N4OForma y color:SolidPeso molecular:382.458AhR agonist 2
<p>AhR agonist 2 is aryl hydrocarbon receptor (AhR) agonist,oral, inducing rapid nuclear enrichment of the AhR and facilitating skin barrier repair,psoriasis.</p>Fórmula:C12H7Br2N3Forma y color:SolidPeso molecular:353.01ND-2158
CAS:<p>ND-2158 is a potent and selective inhibitor of IRAK4.</p>Fórmula:C22H30N4O4SPureza:98%Forma y color:SolidPeso molecular:446.56TLR4/NF-κB/MAPK-IN-1
CAS:<p>TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.</p>Fórmula:C19H25BrO6Forma y color:SolidPeso molecular:429.3CD73-IN-2
<p>CD73-IN-2 is a potent inhibitor of CD73 (IC50: 0.09 nM).</p>Fórmula:C17H25ClN5O7PForma y color:SolidPeso molecular:477.84nNOS-IN-5
CAS:<p>nNOS-IN-5 (Compound 9) is a potent inhibitor of human neuronal nitric oxide synthase (nNOS) with a Ki of 22 nM. It exhibits remarkable selectivity, being 900 times more selective for human nNOS over endothelial nitric oxide synthase (eNOS). nNOS-IN-5 is applicable in research related to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>Fórmula:C23H22N4OForma y color:SolidPeso molecular:370.447NOD1/2 antagonist-1
CAS:<p>NOD1/2 antagonist-1 inhibits NOD1 (IC50 1.13 μM) and NOD2 (IC50 0.77 μM), enhances paclitaxel antitumor efficacy and is used to study innate immune signaling.</p>Fórmula:C32H28ClF5N4O4Pureza:99.69%Forma y color:SolidPeso molecular:663.03Rafutrombopag
CAS:<p>Rafutrombopag is a thrombopoietin (TPO) agonist.</p>Fórmula:C25H22N4O5Forma y color:SolidPeso molecular:458.47CDA-IN-3
CAS:<p>CDA-IN-3 (NCDI) is a chitin deacetylase (CDA) inhibitor with antiparasitic properties. It disrupts chitin metabolism in nematodes, increasing ROS levels within these organisms and causing cellular damage. CDA-IN-3 significantly inhibits all developmental stages of Caenorhabditis elegans and can be utilized in research focused on anti-infective applications.</p>Fórmula:C16H27N3O3S2Forma y color:SolidPeso molecular:373.534iNOS/PGE2-IN-1
<p>iNOS/PGE2-IN-1: iNOS/PGE2 inhibitor, reduces LPS-induced NO, low ulcer risk, anti-inflammatory.</p>Fórmula:C26H22ClN3O4Forma y color:SolidPeso molecular:475.92ARG1-IN-1
CAS:<p>ARG1-IN-1 is a human arginase 1 inhibitor with an IC 50 of 29 nM.</p>Fórmula:C11H21BN2O4Forma y color:SolidPeso molecular:256.11TMV-IN-8
CAS:<p>TMV-IN-8 (compound 7d) is an anti-tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL. TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppresses TMV coat protein gene expression and biosynthesis process [1].</p>Fórmula:C26H22N6O4Forma y color:SolidPeso molecular:482.49NLRP3/AIM2-IN-1
<p>NLRP3/AIM2-IN-1 is an inhibitor of thermal sepsis (IC50 = 3.136 ± 0.7667 μM).</p>Fórmula:C15H16BNO4Forma y color:SolidPeso molecular:285.1YE6144
CAS:<p>YE6144, IRF5 phosphorylation blocker. Affordable Excellence: Reliable Quality You Can Trust</p>Fórmula:C21H27ClFN7OForma y color:SolidPeso molecular:447.94Galectin-3-IN-6
CAS:<p>Galectin-3-IN-6 (Compound 12) is an orally active galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM and a Kd of 13 nM for Gal-3. In a CCl4-induced mouse model of acute liver injury and fibrosis, Galectin-3-IN-6 significantly reduces fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, demonstrating notable anti-fibrotic activity. Galectin-3-IN-6 is applicable for research in fibrosis-related diseases, cancer, and cardiovascular disorders.</p>Fórmula:C28H29Cl2F3N4O6Forma y color:SolidPeso molecular:645.454SDH-IN-25
CAS:<p>SDH-IN-25 is an SDH inhibitor with an IC50 of 4.82 mg/L, demonstrating broad-spectrum and potent antifungal activity. By binding to SDH amino acid residues (TRP173, TYR58, and ARG43), it mimics the action mode of the commercial fungicide flutolanil. SDH-IN-25 induces changes in hyphal morphology, disrupts respiratory metabolism by binding to complex II, generates reactive oxygen species (ROS), and affects mitochondrial membrane potential (MMP) in hyphae. This compound is utilized in agricultural disease control research.</p>Fórmula:C19H15BrCl2N2O4Forma y color:SolidPeso molecular:486.143NOS-IN-2
<p>NOS-IN-2: potent, selective imidamide NOS inhibitor, IC50=20μM for iNOS, spares eNOS, low toxicity, useful in inflammation research.</p>Fórmula:C18H20F3N3O2Forma y color:SolidPeso molecular:367.37IRAK4-IN-9
CAS:<p>IRAK4-IN-9 is a potent IRAK4 inhibitor with an IC50 of 1.5 nM, promising for inflammatory, autoimmune diseases, and cancer research.</p>Fórmula:C22H25N7Forma y color:SolidPeso molecular:387.48STING agonist-7
<p>STING agonist-7 is an agonist of non-nucleotide STING that binds selectively to mouse STING but not human STING [1].</p>Fórmula:C17H12N4O4Forma y color:SolidPeso molecular:336.3trans-3-(3-Pyridyl)acrylic acid
CAS:<p>Trans-3-(3-Pyridyl)acrylic acid (compound 15) is a trans-3-aryl acrylic acid demonstrating antiviral activity against tobacco mosaic virus (TMV) [1].</p>Fórmula:C8H7NO2Forma y color:SolidPeso molecular:149.15(R)-cGAS-IN-4
CAS:<p>(R)-cGAS-IN-4 (Compound 77A*) is the R-enantiomer of cGAS-IN-4, which acts as an orally active inhibitor of cyclic GMP-AMP synthase-adenosine synthase (cGAS).</p>Fórmula:C19H18Cl2N4O3Forma y color:SolidPeso molecular:421.28NLRP3-IN-56
CAS:<p>NLRP3-IN-56 (compound 062) is an inhibitor of NLRP3. It effectively suppresses the secretion of IL-1β in THP-1 cells, demonstrating an IC50 of 9.7 nM. NLRP3-IN-56 is useful for research into NLRP3-mediated symptoms and/or diseases.</p>Fórmula:C20H18ClN3O3Forma y color:SolidPeso molecular:383.83GB1490
CAS:<p>GB1490 is an orally administered galectin inhibitor, demonstrating Kd values of 0.4 μM for galectin-1 and 2.7 μM for galectin-3 [1].</p>Fórmula:C17H15Cl2FN4O4S2Forma y color:SolidPeso molecular:493.36Carazostatin
CAS:<p>Carazostatin is an antioxidant, free radical scavenger, and potent lipid peroxidation inhibitor.</p>Fórmula:C20H25NOPureza:98%Forma y color:Pale Yellow SolidPeso molecular:295.42HEI3090
CAS:<p>HEI3090 is an activator of the P2X7R receptor. This compound enhances the production of IL-18 by stimulating dendritic cells that express P2X7R, which in turn promotes the production of IFN-γ by natural killer cells and CD4T cells within tumors, triggering a sustained anti-tumor response. Additionally, HEI3090 can be used to improve the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC).</p>Fórmula:C18H15Cl3N4O3Forma y color:SolidPeso molecular:441.70BIO-8169
CAS:<p>BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu,u of 0.7.</p>Fórmula:C24H27N5O4Forma y color:SolidPeso molecular:449.50Glutathione monoethyl ester
CAS:<p>Glutathione monoethyl ester, a derivative of glutathione, can protect motor neuron cells (NSC-34) from TDP-43 pathology caused by mutations, which includes reducing aggregate formation, nuclear clearance, reactive oxygen species (ROS) production, and cell death.</p>Fórmula:C12H21N3O6SForma y color:SolidPeso molecular:335.377Pelecopan
CAS:<p>Pelecopan (BCX9930), an oral complement factor D inhibitor, prevents hemolysis in PNH (IC50=14.3 nM).</p>Fórmula:C23H19FN2O4Forma y color:SolidPeso molecular:406.41cGAS-IN-2
CAS:<p>cGAS-IN-2 (compound 109) serves as a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), exhibiting an IC50 of 0.01512 μM against h-cGAS [1].</p>Fórmula:C16H18Cl2N2O2Forma y color:SolidPeso molecular:341.23NLRP3-IN-69
CAS:<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Fórmula:C25H24O7Forma y color:SolidPeso molecular:436.454COX-2-IN-51
CAS:<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Fórmula:C23H18F4O3SForma y color:SolidPeso molecular:450.446NLRP3-IN-29
CAS:<p>NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) with potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. It can be used for research on Alzheimer's disease [1].</p>Fórmula:C21H22N2O3SForma y color:SolidPeso molecular:382.48VISTA-IN-3
CAS:<p>VISTA-IN-3 (Compound A4), a potent small molecule inhibitor of VISTA, exhibits a dissociation constant (K D) of 0.49 μM. This compound effectively induces the release of IFN-γ cytokines and demonstrates synergistic enhancement of anti-cancer activity when combined with PD-L1 antibody [1].</p>Fórmula:C14H18N4O3Forma y color:SolidPeso molecular:290.32IKZF1-degrader-1
CAS:IKZF1-degrader-1 (Compound 9-B) serves as a potent degrader of the IKZF1 protein, exhibiting a DC50 of 0.134 nM. It is applicable in the degradation of tumors [1].Fórmula:C35H29F2N5O3Forma y color:SolidPeso molecular:605.63Galectin-3-IN-4
CAS:<p>Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1].</p>Fórmula:C24H22ClF2N5O5SForma y color:SolidPeso molecular:565.98OP-5244
CAS:<p>OP-5244 has comparable potency to bisphosphonic acid series and targets CD73.</p>Fórmula:C19H29ClN5O9PPureza:98%Forma y color:SolidPeso molecular:537.89NLRP3-IN-78
CAS:<p>NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.</p>Fórmula:C12H5Cl2N3O4S2Forma y color:SolidPeso molecular:390.222STAT1/3-IN-1
CAS:<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Fórmula:C28H25ClN6O5Forma y color:SolidPeso molecular:560.988Ac5GalNTGc
CAS:<p>Ac5GalNTGc, an analog of hexosamine, inhibits mucin-type O-linked glycosylation biosynthesis [1].</p>Fórmula:C18H25NO11SForma y color:SolidPeso molecular:463.4620-Hydroxyvitamin D3
CAS:<p>20-Hydroxyvitamin D3 (20(OH)D3) is a hydroxy metabolite of vitamin D3. It functions as a ligand for the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor (LXR), and retinoic acid receptor-related orphan receptor (ROR). 20-Hydroxyvitamin D3 inhibits cell proliferation and induces differentiation. It is applicable in research on inflammatory and autoimmune diseases.</p>Fórmula:C27H44O2Forma y color:SolidPeso molecular:400.637AhR agonist 7
CAS:Compound 8, an AhR agonist 7, demonstrates potent activation of AhR with an EC50 of 13nM [1].Fórmula:C16H15ClFNO2Forma y color:SolidPeso molecular:307.75ALR-6
CAS:<p>ALR-6, an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP, possesses anti-inflammatory properties. It significantly inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without substantially affecting direct inhibition of 5-LOX [1].</p>Fórmula:C18H14O5Forma y color:SolidPeso molecular:310.3AHR antagonist 5 hemimaleate
<p>Potent oral AHR antagonist with IC50 < 0.5 μM, hinders tumor growth with anti-PD-1.</p>Fórmula:C29H28FN7O4Forma y color:SolidPeso molecular:499.55CD73-IN-7
CAS:<p>CD73-IN-7: potent inhibitor of CD73, blocks adenosine production to treat tumors.</p>Fórmula:C13H11ClN4O2Forma y color:SolidPeso molecular:290.7Heme Oxygenase-2-IN-1
<p>Heme Oxygenase-2-IN-1 is a selective HO-2 inhibitor with IC50s: 14.9 μM (HO-1), 0.9 μM (HO-2).</p>Fórmula:C19H17N3O2Forma y color:SolidPeso molecular:319.36Hetrombopag olamine
CAS:<p>Hetrombopag olamine is a non-peptide thrombopoietin (TPO) receptor agonist with oral activity.</p>Fórmula:C29H36N6O7Pureza:98%Forma y color:SolidPeso molecular:580.63RuDiOBn
CAS:<p>RuDiOBn exhibits low antioxidant activity by scavenging DPPH and ABTS free radicals with scavenging rates of 13.2% and 5.9% at a concentration of 100 μg/mL. It inhibits collagen glycation and reduces the formation of advanced glycation end-products (AGE) with an IC50 of 2.45 μg/mL. RuDiOBn also enhances fibroblast proliferation and migration, stimulates collagen synthesis, and aids in skin repair and regeneration while inhibiting collagenase.</p>Fórmula:C29H22O7Forma y color:SolidPeso molecular:482.481Galectin-3-IN-3
CAS:<p>Galectin-3-IN-3 (Compound 4) serves as a selective and orally active inhibitor targeting Gal-3. It exhibits IC50 values of 11 nM for mGal-3 and 84 nM for hGal-3 [1].</p>Fórmula:C25H22ClF2N7O4SForma y color:SolidPeso molecular:590.00STING agonist-21
CAS:<p>STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].</p>Fórmula:C17H11F6N5O2Forma y color:SolidPeso molecular:431.29ALR-27
CAS:<p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>Fórmula:C19H22O3Forma y color:SolidPeso molecular:298.38TE-11
CAS:<p>TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.</p>Fórmula:C16H13NOForma y color:SolidPeso molecular:235.28SB24011
CAS:<p>SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].</p>Fórmula:C34H38N4O7Forma y color:SolidPeso molecular:614.69IKZF1-degrader-2
CAS:<p>IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].</p>Fórmula:C33H30FN5O5Forma y color:SolidPeso molecular:595.62IRAK4 modulator-1
CAS:<p>IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].</p>Fórmula:C19H13ClN4O2Forma y color:SolidPeso molecular:364.79NIK-IN-2
CAS:<p>NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.</p>Fórmula:C20H22N4O3Forma y color:SolidPeso molecular:366.41NLRP3-IN-57
<p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>Fórmula:C44H60O7Forma y color:SolidPeso molecular:700.94Factor B-IN-3
CAS:<p>Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.</p>Fórmula:C24H29N3O4Forma y color:SolidPeso molecular:423.5TBK1/IKKε-IN-1
CAS:<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Fórmula:C28H26N4O5Pureza:98%Forma y color:SolidPeso molecular:498.53DEG-35
CAS:<p>DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).</p>Fórmula:C25H21N3O5Forma y color:SolidPeso molecular:443.45IRAK4-IN-31
CAS:<p>IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).</p>Fórmula:C27H33N5O5Forma y color:SolidPeso molecular:507.58Factor B-IN-4
CAS:<p>Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.</p>Fórmula:C27H32N2O4Forma y color:SolidPeso molecular:448.55TMC353121
CAS:<p>TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).</p>Fórmula:C32H42N6O3Pureza:≥98%Forma y color:SolidPeso molecular:558.71COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Fórmula:C16H17N5O2Forma y color:SolidPeso molecular:311.34Numidargistat
CAS:<p>CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2).</p>Fórmula:C11H22BN3O5Pureza:98%Forma y color:SolidPeso molecular:287.12COX-2-IN-7
<p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>Fórmula:C15H13N3O2S2Forma y color:SolidPeso molecular:331.41meso-Zeaxanthin
CAS:<p>meso-Zeaxanthin accumulates in the central retina and, together with lutein and zeaxanthin, forms the macular pigment, which functions as a light filter. meso-Zeaxanthin can quench reactive oxygen species (ROS), thereby exhibiting antioxidant properties.</p>Fórmula:C40H56O2Forma y color:SolidPeso molecular:568.871XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Fórmula:C24H20N4O2SForma y color:SolidPeso molecular:428.51Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Fórmula:C17H13BrN4O3S2Forma y color:SolidPeso molecular:465.346,2′,4′-Trimethoxyflavone
CAS:<p>6,2′,4′-Trimethoxyflavone is an AhR antagonist that does not demonstrate effective protection against ischemia-reperfusion injury in the brain of Sprague-Dawley rats.</p>Fórmula:C18H18O5Forma y color:SolidPeso molecular:314.332IRAK1/4/pan-FLT3 Kinase-IN-2
CAS:<p>IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.</p>Fórmula:C20H22F3N5OForma y color:SolidPeso molecular:405.42A-9758
CAS:<p>A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.</p>Fórmula:C25H23Cl2F3N2O3Pureza:98%Forma y color:SolidPeso molecular:527.36PB01
CAS:<p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>Fórmula:C18H21N5O3Forma y color:SolidPeso molecular:355.391Hypoxystat
CAS:<p>Hypoxystat increases the affinity of hemoglobin for oxygen, thereby reducing the release of oxygen to tissues and inducing tissue hypoxia. [Hypoxystat] can alleviate mitochondrial disorder Leigh syndrome in Ndufs4 gene knockout mouse models. Hypoxystat is orally active.</p>Fórmula:C21H21NO5Forma y color:SolidPeso molecular:367.395Keap1-Nrf2-IN-5
CAS:<p>Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).</p>Fórmula:C23H30N4O6SForma y color:SolidPeso molecular:490.57COX-2/NO-IN-1
<p>COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>Fórmula:C15H15NO3Forma y color:SolidPeso molecular:257.28Methoxyurea
CAS:<p>Methoxyurea (Compound 3) is a potential modulator of nitric oxide (NO) donors, interacting with hemoglobin forms such as oxyhemoglobin (OxyHb) and methemoglobin (MetHb). It holds promise for use in research on sickle cell disease (SCD).</p>Fórmula:C2H6N2O2Forma y color:SolidPeso molecular:90.081CD73-IN-12
<p>CD73-IN-12, a compound from CN114437038A, shows strong anti-tumor activity by effectively inhibiting CD73 enzyme.</p>Fórmula:C17H14F2N4O2Forma y color:SolidPeso molecular:344.32AMC-04
CAS:<p>AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].</p>Fórmula:C26H28N2O3Forma y color:SolidPeso molecular:416.51HG-12-6
CAS:<p>HG-12-6 is a type II IRAK4 inhibitor, targeting its inactive form with an IC50 of 165 nM, and is used in autoimmunity and inflammation.</p>Fórmula:C29H27F3N6O2SPureza:98%Forma y color:SolidPeso molecular:580.62STING-IN-11
CAS:<p>STING-IN-11 (Compound 42) is an orally active STING inhibitor with an IC50 of 37.8 nM. It impedes palmitoylation of the STING protein and the downstream signaling of STING, thereby inhibiting STING-mediated inflammation. STING-IN-11 demonstrates good in vivo safety and can be utilized for research on STING-related inflammatory and autoimmune diseases.</p>Fórmula:C21H20ClF2N3OForma y color:SolidPeso molecular:403.853(S)-MALT1-IN-5
CAS:<p>(S)-MALT1-IN-5: Potent MALT1 protease inhibitor, may help in abnormal T/B-cell signalling and MALT1-linked diseases.</p>Fórmula:C17H17ClF2N6O3Forma y color:SolidPeso molecular:426.80ABZI
CAS:<p>(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.</p>Fórmula:C23H24N6O3Peso molecular:432.48IRAK4-IN-30
CAS:<p>IRAK4-IN-30 (Compound I) is an inhibitor of IRAK4, with an IC50 of 0.6 nM.</p>Fórmula:C27H33N5O5Forma y color:SolidPeso molecular:507.581Galectin-8-IN-1
<p>Galectin-8-IN-1 selectively binds galectin-8N with 48 μM affinity, 15x more than galectin-3.</p>Fórmula:C16H18N2O6Forma y color:SolidPeso molecular:334.32NOTA-FAPI
CAS:<p>NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.</p>Fórmula:C36H47F2N9O8Pureza:99.748%Forma y color:SolidPeso molecular:771.81COX-2/15-LOX-IN-5
CAS:<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Fórmula:C25H21N3O3SForma y color:SolidPeso molecular:443.52AM679
CAS:<p>AM679: potent, selective FLAP inhibitor; IC50s—2.2 nM (FLAP), 0.6 nM (hLA), 154 nM (hWB); blocks leukotrienes in vivo; no significant CYP3A4 interaction.</p>Fórmula:C40H44N4O5SPureza:98%Forma y color:SolidPeso molecular:692.87RIPK1-IN-19
CAS:<p>RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.</p>Fórmula:C28H25FN6O2Pureza:98.81%Forma y color:SolidPeso molecular:496.54NLRP3-IN-6
<p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>Fórmula:C18H15ClN2O4S3Forma y color:SolidPeso molecular:454.97E 5090
CAS:<p>E5090 is a novel orally active inhibitor of IL-1 generation. It also has anti-inflammatory properties.</p>Fórmula:C19H20O5Pureza:98%Forma y color:SolidPeso molecular:328.36Cryptopleurine
CAS:<p>Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.</p>Fórmula:C24H27NO3Pureza:98%Forma y color:SolidPeso molecular:377.48Nrf2-ARE/hMAO-B/QR2 modulator 1
CAS:<p>Nrf2-ARE/hMAO-B/QR2 modulator 1 a resveratrol derivative activated the NRF2-ARE inhibit hMAO-B and QR2, promote hippocampal neurogenesis Alzheimer's disease .</p>Fórmula:C14H12N2O3Pureza:98.5%Forma y color:SolidPeso molecular:256.26S-MTC acetate
CAS:<p>S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.</p>Fórmula:C9H19N3O4SForma y color:SolidPeso molecular:265.33IRAK4-IN-12
<p>IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).</p>Fórmula:C24H31FN8OForma y color:SolidPeso molecular:466.55CD73-IN-18
CAS:<p>CD73-IN-18 (compound 35j) is an orally effective inhibitor of the extracellular 5'-nucleotidase (CD73) enzyme. It can be utilized in anticancer research.</p>Fórmula:C20H17N5O3Forma y color:SolidPeso molecular:375.38mPGES1-IN-4
CAS:<p>mPGES1-IN-4 (compound 32) is a multi-substituted pyrimidine compound acting as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and significantly suppresses acute inflammation models in vivo.</p>Fórmula:C27H25F2N3OForma y color:SolidPeso molecular:445.50NLRP3-IN-53
CAS:<p>NLRP3-IN-53 (compound 1) is an NLRP3 inhibitor with an IC50 of 3.4nM.</p>Fórmula:C22H27N5O4Forma y color:SolidPeso molecular:425.48IRAK4-IN-19
<p>IRAK4-IN-19, an IRAK4 inhibitor (IC50: 4.3 nM), hampers IL23 synthesis and arthritis progression.</p>Fórmula:C25H26F2N8OForma y color:SolidPeso molecular:492.52VS-15
CAS:<p>VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.</p>Fórmula:C29H27N5O3Forma y color:SolidPeso molecular:493.56MALT1-IN-11
CAS:<p>MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.</p>Fórmula:C20H16F4N8OForma y color:SolidPeso molecular:460.39YM-I-26
CAS:<p>YM-I-26 is a selective inhibitor of the NLRP3 inflammasome. This compound enhances the phagocytic activity of β-amyloid in murine microglial BV2 cells and reduces the production of IL-1β and IL-10. YM-I-26 is useful for research into inflammation-related immunomodulatory activities.</p>Fórmula:C28H33ClN2O5S2Forma y color:SolidPeso molecular:577.16(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Fórmula:C16H14O3Forma y color:SolidPeso molecular:254.28NOD1-IN-1
CAS:<p>NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.</p>Fórmula:C16H14ClN3O3Forma y color:SolidPeso molecular:331.75BMY-25551
CAS:BMY-25551, a Mitomycin A analog, exhibits cytotoxicity 8 to 20 times greater than Mitomycin C against both murine and human tumor cell lines. It is applicable in research pertaining to cancer and hematological disorders.Fórmula:C17H21N3O7Forma y color:SolidPeso molecular:379.36SLC7A11-IN-2
CAS:<p>SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.</p>Fórmula:C19H24N4O3Forma y color:SolidPeso molecular:356.424-Octylphenol
CAS:<p>4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.</p>Fórmula:C14H22OForma y color:SolidPeso molecular:206.32α-Gracinoic acid
CAS:<p>α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.</p>Fórmula:C29H42O4Forma y color:SolidPeso molecular:454.64ASP-8731
CAS:<p>ASP8731 is a selective inhibitor of BACH1 that prevents inflammation and vascular occlusion, and induces fetal hemoglobin in sickle cell disease.</p>Fórmula:C20H21N5O4Forma y color:SolidPeso molecular:395.41
