Inmunología e inflamación
Los inhibidores de inmunología e inflamación son compuestos que modulan la respuesta inmunitaria y los procesos inflamatorios. Estos inhibidores son cruciales para estudiar los mecanismos de regulación inmunitaria, la autoinmunidad y la inflamación crónica, así como para desarrollar tratamientos para enfermedades inflamatorias, alergias y trastornos relacionados con el sistema inmunológico. Al dirigirse a vías clave en el sistema inmunológico, estos inhibidores pueden ayudar a reducir las respuestas inmunitarias excesivas o inadecuadas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Subcategorías de "Inmunología e inflamación"
- CCR(136 productos)
- CXCR(148 productos)
- Pared celular(5 productos)
- Receptor de IL(112 productos)
- IκB / IKK(60 productos)
- LTR(3 productos)
- MALT(23 productos)
- MRP(6 productos)
- NADPH-oxidasa(1 productos)
- NF-κB(444 productos)
- NOD(17 productos)
- NOS(63 productos)
- Nrf2(79 productos)
- PGE sintasa(31 productos)
- ROS(69 productos)
- TGF-beta / Smad(58 productos)
- TLR(66 productos)
- Tiorredoxina(12 productos)
- gp120 / CD4(4 productos)
Mostrar 11 subcategorías más
Se han encontrado 3045 productos de "Inmunología e inflamación"
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7-O-Methylaloeasinol
CAS:<p>7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.</p>Fórmula:C20H26O9Forma y color:SolidPeso molecular:410.419PF-06426779
CAS:<p>PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4) , with an IC 50 of 0.3 nM.</p>Fórmula:C17H18FN3O4Forma y color:SolidPeso molecular:347.346CRX 527
CAS:<p>CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.</p>Fórmula:C81H151N2O19PForma y color:SolidPeso molecular:1488.043-O-(2'E,4'Z-Decadienoyl)ingenol
<p>3-O-(2'E,4'Z-Decadienoyl)ingenol is a useful organic compound for research related to life sciences and the catalog number is T124104.</p>Fórmula:C30H42O6Forma y color:SolidPeso molecular:498.66PIC1 PA TFA
<p>PIC1 PATFA is the trifluoroacetate form of PIC1 PA. PIC1 PA TFA is a peptide composed of 15 amino acids and serves as an effective PIC1 analog capable of inhibiting complement activation mediated by the classical pathway.</p>Fórmula:C71H123N19O21S2·xC2HF3O2Forma y color:SolidAChE-IN-82
<p>AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. It inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50 values of 0.072, 9.81, 14.52, 0.024, and 2.42 μM, respectively. Additionally, AChE-IN-82 inhibits COX-1, COX-2, and 5-LOX with IC50 values of 60.41, 0.187, and 0.18 μM, respectively. The compound also demonstrates strong neuroprotective effects by significantly reducing H2O2-induced oxidative stress.</p>Fórmula:C21H18N4O5S2Forma y color:SolidPeso molecular:470.52Tuparstobart
CAS:<p>Tuparstobart (Incagn-02385) is an IgG1κ monoclonal antibody that targets the immune checkpoint receptor protein LAG-3, which is predominantly expressed on</p>Forma y color:LiquidKeap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Fórmula:C17H21Cl2N2O5PS3Forma y color:SolidPeso molecular:531.434FGT-4
<p>FGT-4 is a chimeric molecule targeting folate receptor β (FR-β) and functions as a TLR7 agonist. It enhances the secretion of iNOS and the pro-inflammatory cytokine IL-6 associated with M1 macrophages and promotes the proliferation of cytotoxic CD8+ T cells. FGT-4 demonstrates antitumor activity in the 4T1 breast cancer mouse model and is applicable for cancer immunotherapy research.</p>Fórmula:C50H57N11O9S2Forma y color:SolidPeso molecular:1019.37821Keap1-Nrf2-IN-27
<p>Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.</p>Forma y color:Odour SolidPSB-24000
<p>PSB-24000 (Compound 27) is a selective ecto-5'-nucleotidase (CD73) inhibitor with a Ki value of 563 nM for inhibiting human CD73, and a Ki of 481 nM in membrane-bound CD73 in triple-negative breast cancer cells. It disrupts CD73’s recognition and action on substrate AMP, preventing AMP-induced immunosuppressive and pro-cancer adenosine production. PSB-24000 is promising for cancer research.</p>Forma y color:Odour SolidAvatrombopag hydrochloride
CAS:<p>Avatrombopag (AKR-501) - oral, nonpeptide TPO receptor agonist, EC50 3.3 nM, boosts platelet production, CYP2C9 and CYP3A substrate.</p>Forma y color:SolidSDH-IN-23
<p>SDH-IN-23 (Compound B21) is an SDH inhibitor with exceptional nematicidal activity. It can suppress nematode feeding, reproduction, and embryonic development while also inducing lethal effects through mechanisms such as oxidative stress, intestinal damage, and SDH inhibition.</p>Fórmula:C19H11ClF6N2O2Forma y color:SolidPeso molecular:448.75Lintuzumab
CAS:<p>Lintuzumab (HuM-195) is an uncoupled humanized mouse monoclonal antibody against CD33 with anti-leukemic activity.</p>Pureza:98% (SDS-PAGE); 98.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.2% (SEC-HPLC)Forma y color:LiquidBRCA2-IN-1
<p>BRCA2-IN-1 (Compound 3j) is a potential BRCA2 inhibitor with antiproliferative activity against the breast cancer MCF-7 cell line. This compound also demonstrates DPPH radical scavenging ability, with an IC50 value of 12.36 µM.</p>Forma y color:Odour SolidEG01377 2HCl
CAS:<p>EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377</p>Fórmula:C26H32Cl2N6O6S2Pureza:98.91%Forma y color:SoildPeso molecular:659.6CD73-IN-17
<p>CD73-IN-17 (compound 19) is an inhibitor of CD73 with an IC50 of 0.1 μM against hCD73. It is applicable in cancer research.</p>Forma y color:Odour SolidLY2409881
CAS:<p>LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.</p>Fórmula:C24H29ClN6OSForma y color:SolidPeso molecular:485.05G3-C12
CAS:<p>G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.</p>Fórmula:C74H115N23O23S2Pureza:98%Forma y color:SolidPeso molecular:1758.99Keap1-Nrf2-IN-3
CAS:<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Fórmula:C31H34N6O3Forma y color:SolidPeso molecular:538.652(±)-Phrymarolin II
CAS:<p>(±)-Phrymarolin II is a promising class of inhibitors that targets the tobacco mosaic virus, representing a novel approach in plant virus suppression.</p>Fórmula:C23H22O10Forma y color:SolidPeso molecular:458.4192-Aminoquinoline
CAS:<p>Compound Fr16621, with CAS No. 580-22-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr16621 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C9H8N2Forma y color:Light Yellow CrystalsPeso molecular:144.18CHBO4
CAS:<p>CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and</p>Fórmula:C15H10BrFOPureza:98.14%Forma y color:SolidPeso molecular:305.14STING agonist-3 trihydrochloride
<p>STING agonist-3 is a selective, non-nucleotide small-molecule with anti-tumor properties and potential in cancer therapy.</p>Fórmula:C37H45Cl3N12O6Pureza:98%Forma y color:SolidPeso molecular:860.19Inflexuside A
CAS:<p>Inflexuside A, an abietane diterpenoid from Isodon inflexus, and Inflexuside B inhibit NO in LPS-stimulated RAW264.7 cells.</p>Fórmula:C26H42O9Forma y color:SolidPeso molecular:498.61STING-IN-12
<p>STING-IN-12 (compound Y2) acts as an inhibitor of STING. It suppresses IFNβ gene expression induced by SR717 with an IC50 of 0.75 μM. Additionally, STING-IN-12 inhibits STING pathway activation induced by the STING agonist SR717 in THP1 cells and by MSA-2 in mice.</p>Forma y color:Odour SolidAβ-IN-6
<p>Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's</p>Fórmula:C28H31N3O4Forma y color:SolidPeso molecular:473.56PROTAC cGAS degrader-1
<p>PROTAC cGAS degrader-1 (Compound TH35) is a potent and selective cGAS PROTAC degrader, exhibiting DC50 values of 0.9 μM in THP-1 cells and 4.6 μM in RAW 264.7 cells. It effectively inhibits the activation of cGAS signaling induced by dsDNA. PROTAC cGAS degrader-1 also demonstrates anti-inflammatory properties, making it suitable for research into cGAS-related inflammatory diseases. (Pink: cGAS inhibitor; Black: Linker; Blue: E3 ligase ligand)</p>Fórmula:C36H33Cl2N7O5Forma y color:SolidPeso molecular:714.6JPE-1375
CAS:<p>JPE-1375: a C5aR1 antagonist, blocks leukocyte mobilization (EC50=6.9 µM), lowers TNF in mice (EC50=4.5 µM), useful for autoimmune/inflammation research.</p>Fórmula:C49H63FN10O9Forma y color:SolidPeso molecular:955.08STING-IN-13
<p>STING-IN-13 is a selective STING inhibitor that effectively suppresses downstream signaling of the STING pathway and STING-mediated inflammation. It exhibits low toxicity and is suitable for research related to STING-associated inflammatory and autoimmune diseases.</p>Forma y color:Odour Solid3′-Hydroxy-4′-O-methylglabridin
CAS:<p>3′-Hydroxy-4′-O-methylglabridin effectively prevents NADH-dependent peroxidation, exhibiting potent antioxidant properties [1].</p>Fórmula:C21H22O5Forma y color:SolidPeso molecular:354.4Lemnalol
CAS:<p>Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.</p>Fórmula:C15H24OPureza:98%Forma y color:SolidPeso molecular:220.35Keap1-Nrf2-IN-25
<p>Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor with an IC50 of 0.55 μM and exhibits a Keap1 binding affinity (Kd of 0.50 μM). This compound activates Nrf2, reducing reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1β, IL-6). Additionally, Keap1-Nrf2-IN-25 provides protective effects against DSS-induced colitis.</p>Fórmula:C25H28N2O6SForma y color:SolidPeso molecular:484.565Biotin-labeled ODN 1585 sodium
<p>Biotin-labeled ODN 1585 (sodium) serves as a potent inducer of IFN and TNFα production and facilitates the assessment of CpG ODN cellular uptake and</p>Forma y color:Odour SolidMoxilubant HCl
CAS:<p>Moxilubant HCl: small molecule LTB4R antagonist for immune, skin, musculoskeletal disorders, and research in psoriasis, arthritis.</p>Fórmula:C26H38ClN3O4Pureza:99.94%Forma y color:SoildPeso molecular:492.05MJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Forma y color:Odour SolidNLRP3-IN-49
<p>NLRP3-IN-49 (compound Z48) is a potent and specific inhibitor of NLRP3, displaying IC50 values of 0.26 μM in THP-1 cells and 0.21 μM in mouse bone marrow-derived macrophages. It directly binds to the NLRP3 protein with a dissociation constant (Kd) of 1.05 μM, effectively preventing the assembly and activation of the NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 is utilized in the research of inflammatory bowel disease.</p>Forma y color:Odour SolidNOD1/2-IN-1
<p>NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor, demonstrating an IC50 value of 1.4 nM in the ADP-Glo assay. It blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathway (IC50 values are 18 nM and 170 nM for NOD1 and NOD2, respectively), thereby reducing inflammatory responses. This compound is utilized in research related to colitis.</p>Forma y color:Odour SolidIsoxaben
CAS:<p>Isoxaben (EL 107) is a specific inhibitor of cell wall biosynthesis, often used as a herbicide, that inhibits the incorporation of radiolabeled glucose into</p>Fórmula:C18H24N2O4Pureza:98.84%Forma y color:SolidPeso molecular:332.39BMS-986251
CAS:<p>BMS-986251: Oral RORγt inverse agonist, EC50 12 nM; inhibits IL-17 (EC50 24 nM); effective in mouse psoriasis models.</p>Fórmula:C30H29F8NO5SForma y color:SolidPeso molecular:667.61Mesalamine impurity P
CAS:<p>Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.</p>Fórmula:C13H11NO6SForma y color:SolidPeso molecular:309.30diABZI-4
CAS:<p>DiABZI-4 is an orally active STING agonist that exhibits broad-spectrum antiviral activity. It functions by activating STING to induce the production of pro-inflammatory cytokines and activation of lymphocytes. This action inhibits the replication of Influenza A virus (IAV), SARS-CoV-2, and Human Rhinovirus (HRV), with an EC50 range of 11.8-199 nM.</p>Fórmula:C40H51Cl2N13O6Forma y color:SolidPeso molecular:880.82Sartorypyrone D
CAS:<p>Sartorypyrone D, from N. fischeri, inhibits NFRD (1.7 μM) and NADH oxidase (3 μM), and fights Gram-positive bacteria.</p>Fórmula:C26H38O4Forma y color:SolidPeso molecular:414.586Sirtuin modulator 2
CAS:<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Fórmula:C19H15N3O2SPureza:99.67%Forma y color:SolidPeso molecular:349.41Ac-LDEETGEFL-NH2
CAS:<p>Ac-LDEETGEFL-NH2 is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor</p>Fórmula:C48H72N10O19Forma y color:SolidPeso molecular:1093.14Septeremophilane E
<p>Septeremophilane E, from Septoria rudbeckiae fungus, inhibits NO production.</p>Fórmula:C21H26O5Forma y color:SolidPeso molecular:358.43NLRP3-IN-75
<p>NLRP3-IN-75 is an orally effective inhibitor of NLRP3, capable of suppressing IL-1β secretion with an IC50 of 23 nM. It selectively inhibits NLRP3 activation by disrupting inflammasome assembly without affecting the assembly of NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 demonstrates excellent anti-inflammatory effects in models of acute peritonitis, diabetic nephropathy, and inflammatory bowel disease (IBD).</p>Forma y color:Odour SolidADP-β-S trisodium
<p>ADP-β-S (trisodium) is an analog of ADP and acts as a partial agonist. It can induce human platelet aggregation and inhibit PGE1-stimulated adenylate cyclase.</p>Fórmula:C10H12N5Na3O9P2SForma y color:SolidPeso molecular:508.95241Nrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Fórmula:C27H26N2O6Forma y color:SolidPeso molecular:474.51Butan-1-amine hydrochloride
CAS:<p>1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).</p>Fórmula:C4H12ClNForma y color:SolidPeso molecular:109.6
