Inmunología e inflamación
Los inhibidores de inmunología e inflamación son compuestos que modulan la respuesta inmunitaria y los procesos inflamatorios. Estos inhibidores son cruciales para estudiar los mecanismos de regulación inmunitaria, la autoinmunidad y la inflamación crónica, así como para desarrollar tratamientos para enfermedades inflamatorias, alergias y trastornos relacionados con el sistema inmunológico. Al dirigirse a vías clave en el sistema inmunológico, estos inhibidores pueden ayudar a reducir las respuestas inmunitarias excesivas o inadecuadas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Subcategorías de "Inmunología e inflamación"
- CCR(136 productos)
- CXCR(148 productos)
- Pared celular(5 productos)
- Receptor de IL(112 productos)
- IκB / IKK(60 productos)
- LTR(3 productos)
- MALT(23 productos)
- MRP(6 productos)
- NADPH-oxidasa(1 productos)
- NF-κB(444 productos)
- NOD(17 productos)
- NOS(63 productos)
- Nrf2(79 productos)
- PGE sintasa(31 productos)
- ROS(69 productos)
- TGF-beta / Smad(58 productos)
- TLR(66 productos)
- Tiorredoxina(12 productos)
- gp120 / CD4(4 productos)
Mostrar 11 subcategorías más
Se han encontrado 3045 productos de "Inmunología e inflamación"
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Claseprubart
CAS:<p>Claseprubart is a monoclonal antibody that targets human complement C1s. It specifically binds to complement C1s, inhibiting the activation of the complement system and exerting immunosuppressive effects. Claseprubart shows potential for research in autoimmune diseases and inflammation-related conditions.</p>Forma y color:LiquidAR20.5
<p>AR20.5 is a human monoclonal antibody targeting MUC1. It enhances the number of activated CD8 T cells, CD3+CD4−CD8− (DN) T cells, and mature dendritic cells in mice with pancreatic tumors. AR20.5 is applicable for research into anti-pancreatic cancer immunity.</p>Forma y color:Odour LiquidIPH5301
<p>IPH5301 is a human IgG1 monoclonal antibody (mAb) that targets NT5E/CD73. It features a functionally silenced Fc domain and specifically inhibits the enzymatic activity of both soluble and membrane-bound CD73, thereby restoring the proliferation of immune T cells. IPH5301 is applicable for research in anti-tumor immunotherapy. Recommended isotype control: HumanIgG1kappa, Isotype Control.</p>Forma y color:Odour LiquidBifarcept
CAS:<p>Bifarcept, a recombinant antibody targeting the interferon receptor type I (IFN-RI), enhances the serum half-life of IFN-β by facilitating its binding.</p>Forma y color:LiquidSTING ligand-4
<p>STING ligand-4 (Compound 2) is a nitro-free covalent STING inhibitor with an IC50 of less than 0.2 μM. It can be utilized in the synthesis of PROTACSTINGdegrader-4.</p>Fórmula:C18H18Cl2N6OForma y color:SolidPeso molecular:404.09191SARS-CoV-2 Mpro-IN-41
<p>SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.</p>Fórmula:C27H23ClN4O3SForma y color:SolidPeso molecular:518.11794AChE-IN-85
<p>AChE-IN-85 (Compound 7k) is an acetylcholinesterase inhibitor with an IC50 of 0.083 μM. It reduces nitric oxide (NO) release, the production of TNF-α and IL-1β, as well as levels of LDH and ROS, and inhibits Aβ42 aggregation. AChE-IN-85 exhibits anti-inflammatory and neuroprotective effects and is applicable for research on diseases such as Alzheimer's.</p>Forma y color:Odour SolidKeap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Fórmula:C17H21Cl2N2O5PS3Forma y color:SolidPeso molecular:531.4341-Hydroxy-ibuprofen
CAS:<p>1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.</p>Fórmula:C13H18O3Forma y color:SolidPeso molecular:222.2802C12-rrw-NH2
<p>C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.</p>Fórmula:C35H58N10O5Forma y color:SolidPeso molecular:698.9NVP-DKY709
CAS:<p>NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers.</p>Fórmula:C25H27N3O3Pureza:99%Forma y color:SolidPeso molecular:417.5Diplacol
CAS:<p>Diplacol, a geranylated flavanone isolated from Paulownia trees (Paulownia coreana UYEKI), exhibits anti-inflammatory properties by inhibiting NO production in LPS-stimulated Raw264.7 cells with an IC50 value of 4.53 μM [1].</p>Fórmula:C25H28O7Forma y color:SolidPeso molecular:440.49ROS inducer 8
<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>Fórmula:C26H31FN6O6Forma y color:SolidPeso molecular:542.56CD22 ligand-1
CAS:<p>CD22 ligand-1 is a potent, selective hCD22 binder (K D 0.335 µM) with potential for B-cell disease research.</p>Fórmula:C33H34N5NaO10Forma y color:SolidPeso molecular:683.64Keap1-Nrf2-IN-25
<p>Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor with an IC50 of 0.55 μM and exhibits a Keap1 binding affinity (Kd of 0.50 μM). This compound activates Nrf2, reducing reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1β, IL-6). Additionally, Keap1-Nrf2-IN-25 provides protective effects against DSS-induced colitis.</p>Fórmula:C25H28N2O6SForma y color:SolidPeso molecular:484.565STING agonist-3 trihydrochloride
<p>STING agonist-3 is a selective, non-nucleotide small-molecule with anti-tumor properties and potential in cancer therapy.</p>Fórmula:C37H45Cl3N12O6Pureza:98%Forma y color:SolidPeso molecular:860.19Cyclo(L-Pro-L-Val)
CAS:<p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>Fórmula:C10H16N2O2Pureza:98.18%Forma y color:SolidPeso molecular:196.25Basiliximab
CAS:<p>Basiliximab: chimeric IgG1 antibody inhibiting interleukin-2 receptor, used for kidney transplant immunosuppression.</p>Pureza:SDS-PAGE:94.1%;SEC-HPLC:95.3%Forma y color:LiquidPeso molecular:144.01 kDaKeap1-Nrf2-IN-3
CAS:<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Fórmula:C31H34N6O3Forma y color:SolidPeso molecular:538.652P2X7-IN-2 TFA
<p>P2X7-IN-2 TFA inhibits IL-Iβ release (IC50=0.01nM), used in autoimmunity, inflammation & cardiovascular research.</p>Fórmula:C24H22F7N3O4Forma y color:SolidPeso molecular:549.44Guselkumab
CAS:<p>Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit.</p>Pureza:SDS-PAGE:95% SEC-HPLC:98.97%Forma y color:LiquidPeso molecular:144.8 kDaAChE-IN-82
<p>AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. It inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50 values of 0.072, 9.81, 14.52, 0.024, and 2.42 μM, respectively. Additionally, AChE-IN-82 inhibits COX-1, COX-2, and 5-LOX with IC50 values of 60.41, 0.187, and 0.18 μM, respectively. The compound also demonstrates strong neuroprotective effects by significantly reducing H2O2-induced oxidative stress.</p>Fórmula:C21H18N4O5S2Forma y color:SolidPeso molecular:470.52Pascolizumab
CAS:<p>Pascolizumab (SB-240683) is a humanized monoclonal antibody against IL-4. Pascolizumab has asthmatic effects and can be used to study allergic rhinitis.</p>Pureza:> 95%Forma y color:LiquidPeso molecular:147.18 kDaNrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Fórmula:C27H26N2O6Forma y color:SolidPeso molecular:474.51Methyl 3,4-Dihydroxyphenylacetate
CAS:<p>Methyl 3,4-Dihydroxyphenylacetate is an effective enterovirus 71 (EV71) inhibitor, suppressing EV71 replication in rhabdomyosarcoma (RD) cells, antiviral.</p>Fórmula:C9H10O4Pureza:97.03%Forma y color:SolidPeso molecular:182.175-LOX/sEH-IN-1
<p>Compound 8o (5-LOX/sEH-IN-1) is a dual inhibitor with cardioprotective properties, targeting both 5-LOX and sEH with IC50 values of 3.05 μM and 2.20 nM respectively. It also inhibits the activity of COX-2 (IC50=10.50 μM). Possessing analgesic and anti-inflammatory properties, 5-LOX/sEH-IN-1 reduces ulcerogenicity, making it a potential candidate for developing anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.</p>Forma y color:Odour Solid(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA
CAS:<p>(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA ((6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-coenzyme A) acts as an NLRX1 modulator. This compound shows potential for research into immune and metabolism-related diseases.</p>Fórmula:C45H70N7O17P3SForma y color:SolidPeso molecular:1106.06COX-2-IN-52
<p>COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.</p>Fórmula:C16H13IN4O4S2Forma y color:SolidPeso molecular:516.3332,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside
CAS:<p>2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside that is commonly found in the bulbs of</p>Fórmula:C20H27Cl3O12Forma y color:SolidPeso molecular:565.78FLY26
<p>FLY26 is a selective partial antagonist of GluN2B, with an IC50 value of 0.64 μM. FLY26 inhibits the GluN2B subunit of NMDA receptors, reducing calcium ion influx and reactive oxygen species (ROS) production. It also activates the BDNF/TrkB/CREB neuroprotective signaling pathway, mitigating excitotoxicity and mitochondrial dysfunction. FLY26 holds potential for treating neurological deficits caused by cerebral ischemia-reperfusion injury.</p>Fórmula:C22H23N5O3Forma y color:SolidPeso molecular:405.18009NT-0249
CAS:<p>NT-0249 is an inflammatory vesicle NLRP3 inhibitor with anti-inflammatory activity that reverses high-fat diet-induced obesity.</p>Fórmula:C22H28N5NaO4SPureza:98.11%Forma y color:SoildPeso molecular:481.54BMS-986251
CAS:<p>BMS-986251: Oral RORγt inverse agonist, EC50 12 nM; inhibits IL-17 (EC50 24 nM); effective in mouse psoriasis models.</p>Fórmula:C30H29F8NO5SForma y color:SolidPeso molecular:667.61Histone Modification Compound Library
<p>A unique collection of xnum histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Forma y color:Odour SolidIromycin A
CAS:<p>Iromycin A: a bacterial metabolite inhibiting NOS III over NOS I, blocks NADH oxidation, IC50 = 0.461 µM.</p>Fórmula:C19H29NO2Forma y color:SolidPeso molecular:303.44BuChE-IN-20
<p>BuChE-IN-20 is a selective hBuChE inhibitor (IC50= 0.13 μM) with the ability to cross the blood-brain barrier (BBB). This compound, a derivative of L-Tryptophan, exhibits neuroprotective effects by inhibiting nitric oxide (NO) production and reducing reactive oxygen species (ROS) levels. It effectively suppresses the self-aggregation of amyloid-beta (Aβ) peptides and is applicable in Alzheimer's disease research.</p>Forma y color:Odour SolidSTING agonist-8 dihydrochloride
<p>STING Agonist-8 Dihydrochloride (Compound 5-AB) is a highly effective STING agonist, exhibiting an EC50 value of 27 nM in THP1-Dual KI-hSTING-R232 cells.</p>Fórmula:C41H48Cl2N14O4Forma y color:SolidPeso molecular:871.82G3-C12
CAS:<p>G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.</p>Fórmula:C74H115N23O23S2Pureza:98%Forma y color:SolidPeso molecular:1758.99Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH
<p>Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH, a linker with TLR4-IN-C34, reduces inflammation in mice.</p>Fórmula:C78H125N7O36Forma y color:SolidPeso molecular:1736.854-ACETAMIDOANTIPYRINE
CAS:<p>4-ACETAMIDOANTIPYRINE, with CAS No. 83-15-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-ACETAMIDOANTIPYRINE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C13H15N3O2Forma y color:SolidPeso molecular:245.28VEN-02XX
<p>VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.</p>Fórmula:C18H16ClF3N4OForma y color:SolidPeso molecular:396.79Inflexuside A
CAS:<p>Inflexuside A, an abietane diterpenoid from Isodon inflexus, and Inflexuside B inhibit NO in LPS-stimulated RAW264.7 cells.</p>Fórmula:C26H42O9Forma y color:SolidPeso molecular:498.61Itolizumab
CAS:<p>Itolizumab (Anti-Human CD6 Recombinant Antibody) is a recombinant anti-CD6 monoclonal antibody that humanizes the extracellular SRCR distal domain 1 of CD6.</p>Pureza:> 95%Forma y color:LiquidPeso molecular:144.82 kDaPS 1145 dihydrochloride
CAS:<p>IκB kinase (IKK) inhibitor</p>Fórmula:C17H13Cl3N4OPureza:98%Forma y color:SolidPeso molecular:395.67JPE-1375
CAS:<p>JPE-1375: a C5aR1 antagonist, blocks leukocyte mobilization (EC50=6.9 µM), lowers TNF in mice (EC50=4.5 µM), useful for autoimmune/inflammation research.</p>Fórmula:C49H63FN10O9Forma y color:SolidPeso molecular:955.08Tuparstobart
CAS:<p>Tuparstobart (Incagn-02385) is an IgG1κ monoclonal antibody that targets the immune checkpoint receptor protein LAG-3, which is predominantly expressed on</p>Forma y color:LiquidCarotuximab
CAS:<p>Carotuximab (DE-122), an antibody, inhibits CD105 to reduce angiogenesis, inflammation, and tumor growth.</p>Pureza:> 95%Forma y color:LiquidPeso molecular:144.8 kDaSericin
<p>Sericin is a globular protein isolated from silkworm cocoons. It has cognitive enhancement and pain-relieving properties. Additionally, Sericin serves as a cryoprotectant, potentially replacing fetal bovine serum or dimethyl sulfoxide (DMSO). It helps reduce oxidative stress and reactive oxygen species (ROS). Sericin aids in wound repair by promoting collagen production and exhibits activities such as antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory, moisturizing, wound healing promotion, antibacterial, and antitumor effects.</p>Forma y color:Odour SolidAloenin aglycone
CAS:<p>Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.</p>Fórmula:C13H12O5Pureza:98%Forma y color:SolidPeso molecular:248.23MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Forma y color:Odour Solidβ-Aminoarteether
CAS:<p>β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders,</p>Fórmula:C17H29NO5Pureza:96.09% - 97.02%Forma y color:SolidPeso molecular:327.42
