Inmunología e inflamación
Los inhibidores de inmunología e inflamación son compuestos que modulan la respuesta inmunitaria y los procesos inflamatorios. Estos inhibidores son cruciales para estudiar los mecanismos de regulación inmunitaria, la autoinmunidad y la inflamación crónica, así como para desarrollar tratamientos para enfermedades inflamatorias, alergias y trastornos relacionados con el sistema inmunológico. Al dirigirse a vías clave en el sistema inmunológico, estos inhibidores pueden ayudar a reducir las respuestas inmunitarias excesivas o inadecuadas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Subcategorías de "Inmunología e inflamación"
- CCR(136 productos)
- CXCR(149 productos)
- Pared celular(5 productos)
- Receptor de IL(112 productos)
- IκB / IKK(59 productos)
- LTR(3 productos)
- MALT(23 productos)
- MRP(6 productos)
- NADPH-oxidasa(1 productos)
- NF-κB(443 productos)
- NOD(18 productos)
- NOS(63 productos)
- Nrf2(78 productos)
- PGE sintasa(31 productos)
- ROS(69 productos)
- TGF-beta / Smad(58 productos)
- TLR(66 productos)
- Tiorredoxina(12 productos)
- gp120 / CD4(4 productos)
Mostrar 11 subcategorías más
Se han encontrado 3054 productos de "Inmunología e inflamación"
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mPGES1-IN-5
CAS:mPGES1-IN-5 (compound 18) is a multi-substituted pyrimidine compound that acts as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and demonstrates significant inhibitory activity in vivo against acute inflammation models.Fórmula:C27H27N3OForma y color:SolidPeso molecular:409.52WK692
CAS:<p>Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.</p>Fórmula:C26H28Br2N8O5Forma y color:SolidPeso molecular:692.36TLR7 agonist 28
CAS:<p>TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.</p>Fórmula:C26H25N9O7Forma y color:SolidPeso molecular:575.533ASP-8731
CAS:<p>ASP8731 is a selective inhibitor of BACH1 that prevents inflammation and vascular occlusion, and induces fetal hemoglobin in sickle cell disease.</p>Fórmula:C20H21N5O4Forma y color:SolidPeso molecular:395.41Anti-inflammatory agent 102
CAS:<p>Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).</p>Fórmula:C16H16ClN3O3Forma y color:SolidPeso molecular:333.77BMS-986458
CAS:<p>BMS-986458 is a highly selective, orally active BCL6 PROTAC degrader. It specifically targets cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity-induced BCL6 degradation. BMS-986458 is applicable for research in B-cell non-Hodgkin lymphoma.</p>Fórmula:C32H34ClN9O3Forma y color:SolidPeso molecular:628.124MAO-B-IN-7
<p>MAO-B-IN-7 inhibits MAO-B/AChE, crossing the blood-brain barrier; IC50: 41/87 nM (h/eel AChE), 0.3 μM (MAO-B). Reduces oxidative stress and neuroinflammation.</p>Fórmula:C25H31NO4Forma y color:SolidPeso molecular:409.52Heme Oxygenase-1-IN-2
<p>Heme Oxygenase-1-IN-2 is a novel inhibitor of heme oxygenase-1 (HO-1), displaying potent antiproliferative activity in vitro, with an IC50 value of 0.95 μM.</p>Fórmula:C19H18ClN3OForma y color:SolidPeso molecular:339.82iNOS/PGE2-IN-1
<p>iNOS/PGE2-IN-1: iNOS/PGE2 inhibitor, reduces LPS-induced NO, low ulcer risk, anti-inflammatory.</p>Fórmula:C26H22ClN3O4Forma y color:SolidPeso molecular:475.92CVN293
CAS:<p>CVN293 is a inhibitor of the potassium channel KCNK13,BBB,It inhibits the production of the pro-inflammatory cytokine IL-1β induced by NLRP3 in microglia</p>Fórmula:C14H10FN7OPureza:99.50%Forma y color:SolidPeso molecular:311.27ROS inducer 9
CAS:<p>ROS inducer 9 (compound 4e) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Escherichia coli. It eradicates bacteria by inhibiting GSH activity and increasing ROS levels. Additionally, ROS inducer 9 exhibits low toxicity toward red blood cells and RAW 264.7 cells.</p>Fórmula:C26H26BrF4N3O3Forma y color:SolidPeso molecular:584.401ODN 21158
CAS:<p>ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.</p>Forma y color:SolidAM679
CAS:<p>AM679: potent, selective FLAP inhibitor; IC50s—2.2 nM (FLAP), 0.6 nM (hLA), 154 nM (hWB); blocks leukotrienes in vivo; no significant CYP3A4 interaction.</p>Fórmula:C40H44N4O5SPureza:98%Forma y color:SolidPeso molecular:692.87RIPK1-IN-19
CAS:<p>RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.</p>Fórmula:C28H25FN6O2Pureza:98.81%Forma y color:SolidPeso molecular:496.54YE6144
CAS:<p>YE6144, IRF5 phosphorylation blocker. Affordable Excellence: Reliable Quality You Can Trust</p>Fórmula:C21H27ClFN7OForma y color:SolidPeso molecular:447.94K-14585
CAS:<p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>Fórmula:C51H56Cl2N8O4Forma y color:SolidPeso molecular:915.95NLRP3-IN-6
<p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>Fórmula:C18H15ClN2O4S3Forma y color:SolidPeso molecular:454.97SLC7A11-IN-2
CAS:<p>SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.</p>Fórmula:C19H24N4O3Forma y color:SolidPeso molecular:356.42Nitric oxide production-IN-2
CAS:<p>TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.</p>Fórmula:C23H20O3Forma y color:SolidPeso molecular:344.403COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Fórmula:C31H32FN5O2SForma y color:SolidPeso molecular:557.68NLRP3-IN-4
<p>NLRP3-IN-4 is an effective, oral NLRP3 inflammasome inhibitor with potent anti-inflammatory effects on colitis.</p>Fórmula:C22H22N2O5Forma y color:SolidPeso molecular:394.42IACS-8779
CAS:<p>IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.</p>Fórmula:C21H25N9O10P2S2Pureza:98%Forma y color:SolidPeso molecular:689.55Fexlamose
CAS:<p>Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).</p>Fórmula:C12H22O9S2Forma y color:SolidPeso molecular:374.428CD73-IN-13
<p>CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.</p>Fórmula:C13H11F3N4O2Forma y color:SolidPeso molecular:312.25Nrf2-ARE/hMAO-B/QR2 modulator 1
CAS:<p>Nrf2-ARE/hMAO-B/QR2 modulator 1 a resveratrol derivative activated the NRF2-ARE inhibit hMAO-B and QR2, promote hippocampal neurogenesis Alzheimer's disease .</p>Fórmula:C14H12N2O3Pureza:98.5%Forma y color:SolidPeso molecular:256.26IRAK4-IN-12
<p>IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).</p>Fórmula:C24H31FN8OForma y color:SolidPeso molecular:466.55BAA473
<p>BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.</p>Fórmula:C36H62O5Pureza:98%Forma y color:SolidPeso molecular:574.87IRAK4-IN-14
CAS:<p>IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.</p>Fórmula:C25H28FN9OForma y color:SolidPeso molecular:489.55IRAK4 ligand-13
CAS:<p>IRAK4ligand-13 is an IRAK4 ligand and serves as a PROTAC target protein ligand. It is utilized in the synthesis of PROTAC compounds, such as LZ-07.</p>Fórmula:C23H26N10Forma y color:SolidPeso molecular:442.52TLR7/8 agonist 7
CAS:<p>TLR7/8 agonist 7 activates immune cells, useful in ISAC synthesis and immunity research.</p>Fórmula:C26H37N7O2Forma y color:SolidPeso molecular:479.62Rafutrombopag
CAS:<p>Rafutrombopag is a thrombopoietin (TPO) agonist.</p>Fórmula:C25H22N4O5Forma y color:SolidPeso molecular:458.47BMY-25551
CAS:BMY-25551, a Mitomycin A analog, exhibits cytotoxicity 8 to 20 times greater than Mitomycin C against both murine and human tumor cell lines. It is applicable in research pertaining to cancer and hematological disorders.Fórmula:C17H21N3O7Forma y color:SolidPeso molecular:379.36CD73-IN-18
CAS:<p>CD73-IN-18 (compound 35j) is an orally effective inhibitor of the extracellular 5'-nucleotidase (CD73) enzyme. It can be utilized in anticancer research.</p>Fórmula:C20H17N5O3Forma y color:SolidPeso molecular:375.38NF-κB-IN-6
<p>NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signaling</p>Fórmula:C14H20N2O3Forma y color:SolidPeso molecular:264.32IRAK4-IN-19
<p>IRAK4-IN-19, an IRAK4 inhibitor (IC50: 4.3 nM), hampers IL23 synthesis and arthritis progression.</p>Fórmula:C25H26F2N8OForma y color:SolidPeso molecular:492.526-Alkyne-F-araNAD
CAS:<p>6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).</p>Fórmula:C24H28FN7O13P2Forma y color:SolidPeso molecular:703.464MALT1-IN-11
CAS:<p>MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.</p>Fórmula:C20H16F4N8OForma y color:SolidPeso molecular:460.39NLRP3-IN-8
CAS:<p>NLRP3-IN-8, orally active inflammasome blocker, IC50 of 1.23μM, stable (t1/2 = 138.63min), non-toxic (IC50 >100μM).</p>Fórmula:C23H20N2O6Forma y color:SolidPeso molecular:420.41YM-I-26
CAS:<p>YM-I-26 is a selective inhibitor of the NLRP3 inflammasome. This compound enhances the phagocytic activity of β-amyloid in murine microglial BV2 cells and reduces the production of IL-1β and IL-10. YM-I-26 is useful for research into inflammation-related immunomodulatory activities.</p>Fórmula:C28H33ClN2O5S2Forma y color:SolidPeso molecular:577.16NOD1-IN-1
CAS:<p>NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.</p>Fórmula:C16H14ClN3O3Forma y color:SolidPeso molecular:331.75(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Fórmula:C16H14O3Forma y color:SolidPeso molecular:254.28GNE-2256
CAS:<p>GNE-2256, also known as molecule 19, is an orally active compound that inhibits Interleukin 1 receptor-associated kinase 4 (IRAK4) with a K i of 1.4 nM and has</p>Fórmula:C24H27FN6O4Forma y color:SolidPeso molecular:482.51α-Gracinoic acid
CAS:<p>α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.</p>Fórmula:C29H42O4Forma y color:SolidPeso molecular:454.64TIM-3-IN-1
<p>TIM-3-IN-1 is a useful tool to enable further studies on the biology of TIM-3 immunoregulation in cancer.</p>Fórmula:C20H16ClN7O3SForma y color:SolidPeso molecular:469.9VS-15
CAS:<p>VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.</p>Fórmula:C29H27N5O3Forma y color:SolidPeso molecular:493.56NLRP3-IN-53
CAS:<p>NLRP3-IN-53 (compound 1) is an NLRP3 inhibitor with an IC50 of 3.4nM.</p>Fórmula:C22H27N5O4Forma y color:SolidPeso molecular:425.48mPGES1-IN-4
CAS:<p>mPGES1-IN-4 (compound 32) is a multi-substituted pyrimidine compound acting as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and significantly suppresses acute inflammation models in vivo.</p>Fórmula:C27H25F2N3OForma y color:SolidPeso molecular:445.50S-MTC acetate
CAS:S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.Fórmula:C9H19N3O4SForma y color:SolidPeso molecular:265.33IL-17 modulator 1 disodium
CAS:<p>Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.</p>Fórmula:C28H37N6NaO6PForma y color:SolidPeso molecular:607.604COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Fórmula:C22H23FN2O6S2Forma y color:SolidPeso molecular:494.56
