Inmunología e inflamación
Los inhibidores de inmunología e inflamación son compuestos que modulan la respuesta inmunitaria y los procesos inflamatorios. Estos inhibidores son cruciales para estudiar los mecanismos de regulación inmunitaria, la autoinmunidad y la inflamación crónica, así como para desarrollar tratamientos para enfermedades inflamatorias, alergias y trastornos relacionados con el sistema inmunológico. Al dirigirse a vías clave en el sistema inmunológico, estos inhibidores pueden ayudar a reducir las respuestas inmunitarias excesivas o inadecuadas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Subcategorías de "Inmunología e inflamación"
- CCR(136 productos)
- CXCR(148 productos)
- Pared celular(5 productos)
- Receptor de IL(112 productos)
- IκB / IKK(60 productos)
- LTR(3 productos)
- MALT(23 productos)
- MRP(6 productos)
- NADPH-oxidasa(1 productos)
- NF-κB(444 productos)
- NOD(17 productos)
- NOS(63 productos)
- Nrf2(79 productos)
- PGE sintasa(31 productos)
- ROS(69 productos)
- TGF-beta / Smad(58 productos)
- TLR(66 productos)
- Tiorredoxina(12 productos)
- gp120 / CD4(4 productos)
Mostrar 11 subcategorías más
Se han encontrado 3045 productos de "Inmunología e inflamación"
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CDA-IN-3
CAS:<p>CDA-IN-3 (NCDI) is a chitin deacetylase (CDA) inhibitor with antiparasitic properties. It disrupts chitin metabolism in nematodes, increasing ROS levels within these organisms and causing cellular damage. CDA-IN-3 significantly inhibits all developmental stages of Caenorhabditis elegans and can be utilized in research focused on anti-infective applications.</p>Fórmula:C16H27N3O3S2Forma y color:SolidPeso molecular:373.534iNOS/PGE2-IN-1
<p>iNOS/PGE2-IN-1: iNOS/PGE2 inhibitor, reduces LPS-induced NO, low ulcer risk, anti-inflammatory.</p>Fórmula:C26H22ClN3O4Forma y color:SolidPeso molecular:475.92ARG1-IN-1
CAS:<p>ARG1-IN-1 is a human arginase 1 inhibitor with an IC 50 of 29 nM.</p>Fórmula:C11H21BN2O4Forma y color:SolidPeso molecular:256.11TMV-IN-8
CAS:<p>TMV-IN-8 (compound 7d) is an anti-tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL. TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppresses TMV coat protein gene expression and biosynthesis process [1].</p>Fórmula:C26H22N6O4Forma y color:SolidPeso molecular:482.49NLRP3/AIM2-IN-1
<p>NLRP3/AIM2-IN-1 is an inhibitor of thermal sepsis (IC50 = 3.136 ± 0.7667 μM).</p>Fórmula:C15H16BNO4Forma y color:SolidPeso molecular:285.1YE6144
CAS:<p>YE6144, IRF5 phosphorylation blocker. Affordable Excellence: Reliable Quality You Can Trust</p>Fórmula:C21H27ClFN7OForma y color:SolidPeso molecular:447.94Galectin-3-IN-6
CAS:<p>Galectin-3-IN-6 (Compound 12) is an orally active galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM and a Kd of 13 nM for Gal-3. In a CCl4-induced mouse model of acute liver injury and fibrosis, Galectin-3-IN-6 significantly reduces fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, demonstrating notable anti-fibrotic activity. Galectin-3-IN-6 is applicable for research in fibrosis-related diseases, cancer, and cardiovascular disorders.</p>Fórmula:C28H29Cl2F3N4O6Forma y color:SolidPeso molecular:645.454SDH-IN-25
CAS:<p>SDH-IN-25 is an SDH inhibitor with an IC50 of 4.82 mg/L, demonstrating broad-spectrum and potent antifungal activity. By binding to SDH amino acid residues (TRP173, TYR58, and ARG43), it mimics the action mode of the commercial fungicide flutolanil. SDH-IN-25 induces changes in hyphal morphology, disrupts respiratory metabolism by binding to complex II, generates reactive oxygen species (ROS), and affects mitochondrial membrane potential (MMP) in hyphae. This compound is utilized in agricultural disease control research.</p>Fórmula:C19H15BrCl2N2O4Forma y color:SolidPeso molecular:486.143NOS-IN-2
<p>NOS-IN-2: potent, selective imidamide NOS inhibitor, IC50=20μM for iNOS, spares eNOS, low toxicity, useful in inflammation research.</p>Fórmula:C18H20F3N3O2Forma y color:SolidPeso molecular:367.37IRAK4-IN-9
CAS:<p>IRAK4-IN-9 is a potent IRAK4 inhibitor with an IC50 of 1.5 nM, promising for inflammatory, autoimmune diseases, and cancer research.</p>Fórmula:C22H25N7Forma y color:SolidPeso molecular:387.48STING agonist-7
<p>STING agonist-7 is an agonist of non-nucleotide STING that binds selectively to mouse STING but not human STING [1].</p>Fórmula:C17H12N4O4Forma y color:SolidPeso molecular:336.3trans-3-(3-Pyridyl)acrylic acid
CAS:<p>Trans-3-(3-Pyridyl)acrylic acid (compound 15) is a trans-3-aryl acrylic acid demonstrating antiviral activity against tobacco mosaic virus (TMV) [1].</p>Fórmula:C8H7NO2Forma y color:SolidPeso molecular:149.15(R)-cGAS-IN-4
CAS:<p>(R)-cGAS-IN-4 (Compound 77A*) is the R-enantiomer of cGAS-IN-4, which acts as an orally active inhibitor of cyclic GMP-AMP synthase-adenosine synthase (cGAS).</p>Fórmula:C19H18Cl2N4O3Forma y color:SolidPeso molecular:421.28NLRP3-IN-56
CAS:<p>NLRP3-IN-56 (compound 062) is an inhibitor of NLRP3. It effectively suppresses the secretion of IL-1β in THP-1 cells, demonstrating an IC50 of 9.7 nM. NLRP3-IN-56 is useful for research into NLRP3-mediated symptoms and/or diseases.</p>Fórmula:C20H18ClN3O3Forma y color:SolidPeso molecular:383.83GB1490
CAS:<p>GB1490 is an orally administered galectin inhibitor, demonstrating Kd values of 0.4 μM for galectin-1 and 2.7 μM for galectin-3 [1].</p>Fórmula:C17H15Cl2FN4O4S2Forma y color:SolidPeso molecular:493.36Carazostatin
CAS:<p>Carazostatin is an antioxidant, free radical scavenger, and potent lipid peroxidation inhibitor.</p>Fórmula:C20H25NOPureza:98%Forma y color:Pale Yellow SolidPeso molecular:295.42HEI3090
CAS:<p>HEI3090 is an activator of the P2X7R receptor. This compound enhances the production of IL-18 by stimulating dendritic cells that express P2X7R, which in turn promotes the production of IFN-γ by natural killer cells and CD4T cells within tumors, triggering a sustained anti-tumor response. Additionally, HEI3090 can be used to improve the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC).</p>Fórmula:C18H15Cl3N4O3Forma y color:SolidPeso molecular:441.70BIO-8169
CAS:<p>BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu,u of 0.7.</p>Fórmula:C24H27N5O4Forma y color:SolidPeso molecular:449.50Glutathione monoethyl ester
CAS:<p>Glutathione monoethyl ester, a derivative of glutathione, can protect motor neuron cells (NSC-34) from TDP-43 pathology caused by mutations, which includes reducing aggregate formation, nuclear clearance, reactive oxygen species (ROS) production, and cell death.</p>Fórmula:C12H21N3O6SForma y color:SolidPeso molecular:335.377Pelecopan
CAS:<p>Pelecopan (BCX9930), an oral complement factor D inhibitor, prevents hemolysis in PNH (IC50=14.3 nM).</p>Fórmula:C23H19FN2O4Forma y color:SolidPeso molecular:406.41cGAS-IN-2
CAS:<p>cGAS-IN-2 (compound 109) serves as a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), exhibiting an IC50 of 0.01512 μM against h-cGAS [1].</p>Fórmula:C16H18Cl2N2O2Forma y color:SolidPeso molecular:341.23NLRP3-IN-69
CAS:<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Fórmula:C25H24O7Forma y color:SolidPeso molecular:436.454COX-2-IN-51
CAS:<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Fórmula:C23H18F4O3SForma y color:SolidPeso molecular:450.446NLRP3-IN-29
CAS:<p>NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) with potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. It can be used for research on Alzheimer's disease [1].</p>Fórmula:C21H22N2O3SForma y color:SolidPeso molecular:382.48VISTA-IN-3
CAS:<p>VISTA-IN-3 (Compound A4), a potent small molecule inhibitor of VISTA, exhibits a dissociation constant (K D) of 0.49 μM. This compound effectively induces the release of IFN-γ cytokines and demonstrates synergistic enhancement of anti-cancer activity when combined with PD-L1 antibody [1].</p>Fórmula:C14H18N4O3Forma y color:SolidPeso molecular:290.32IKZF1-degrader-1
CAS:IKZF1-degrader-1 (Compound 9-B) serves as a potent degrader of the IKZF1 protein, exhibiting a DC50 of 0.134 nM. It is applicable in the degradation of tumors [1].Fórmula:C35H29F2N5O3Forma y color:SolidPeso molecular:605.63Galectin-3-IN-4
CAS:<p>Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1].</p>Fórmula:C24H22ClF2N5O5SForma y color:SolidPeso molecular:565.98OP-5244
CAS:<p>OP-5244 has comparable potency to bisphosphonic acid series and targets CD73.</p>Fórmula:C19H29ClN5O9PPureza:98%Forma y color:SolidPeso molecular:537.89NLRP3-IN-78
CAS:<p>NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.</p>Fórmula:C12H5Cl2N3O4S2Forma y color:SolidPeso molecular:390.222STAT1/3-IN-1
CAS:<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Fórmula:C28H25ClN6O5Forma y color:SolidPeso molecular:560.988Ac5GalNTGc
CAS:<p>Ac5GalNTGc, an analog of hexosamine, inhibits mucin-type O-linked glycosylation biosynthesis [1].</p>Fórmula:C18H25NO11SForma y color:SolidPeso molecular:463.4620-Hydroxyvitamin D3
CAS:<p>20-Hydroxyvitamin D3 (20(OH)D3) is a hydroxy metabolite of vitamin D3. It functions as a ligand for the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor (LXR), and retinoic acid receptor-related orphan receptor (ROR). 20-Hydroxyvitamin D3 inhibits cell proliferation and induces differentiation. It is applicable in research on inflammatory and autoimmune diseases.</p>Fórmula:C27H44O2Forma y color:SolidPeso molecular:400.637AhR agonist 7
CAS:Compound 8, an AhR agonist 7, demonstrates potent activation of AhR with an EC50 of 13nM [1].Fórmula:C16H15ClFNO2Forma y color:SolidPeso molecular:307.75ALR-6
CAS:<p>ALR-6, an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP, possesses anti-inflammatory properties. It significantly inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without substantially affecting direct inhibition of 5-LOX [1].</p>Fórmula:C18H14O5Forma y color:SolidPeso molecular:310.3AHR antagonist 5 hemimaleate
<p>Potent oral AHR antagonist with IC50 < 0.5 μM, hinders tumor growth with anti-PD-1.</p>Fórmula:C29H28FN7O4Forma y color:SolidPeso molecular:499.55CD73-IN-7
CAS:<p>CD73-IN-7: potent inhibitor of CD73, blocks adenosine production to treat tumors.</p>Fórmula:C13H11ClN4O2Forma y color:SolidPeso molecular:290.7Heme Oxygenase-2-IN-1
<p>Heme Oxygenase-2-IN-1 is a selective HO-2 inhibitor with IC50s: 14.9 μM (HO-1), 0.9 μM (HO-2).</p>Fórmula:C19H17N3O2Forma y color:SolidPeso molecular:319.36Hetrombopag olamine
CAS:<p>Hetrombopag olamine is a non-peptide thrombopoietin (TPO) receptor agonist with oral activity.</p>Fórmula:C29H36N6O7Pureza:98%Forma y color:SolidPeso molecular:580.63RuDiOBn
CAS:<p>RuDiOBn exhibits low antioxidant activity by scavenging DPPH and ABTS free radicals with scavenging rates of 13.2% and 5.9% at a concentration of 100 μg/mL. It inhibits collagen glycation and reduces the formation of advanced glycation end-products (AGE) with an IC50 of 2.45 μg/mL. RuDiOBn also enhances fibroblast proliferation and migration, stimulates collagen synthesis, and aids in skin repair and regeneration while inhibiting collagenase.</p>Fórmula:C29H22O7Forma y color:SolidPeso molecular:482.481Galectin-3-IN-3
CAS:<p>Galectin-3-IN-3 (Compound 4) serves as a selective and orally active inhibitor targeting Gal-3. It exhibits IC50 values of 11 nM for mGal-3 and 84 nM for hGal-3 [1].</p>Fórmula:C25H22ClF2N7O4SForma y color:SolidPeso molecular:590.00STING agonist-21
CAS:<p>STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].</p>Fórmula:C17H11F6N5O2Forma y color:SolidPeso molecular:431.29ALR-27
CAS:<p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>Fórmula:C19H22O3Forma y color:SolidPeso molecular:298.38TE-11
CAS:<p>TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.</p>Fórmula:C16H13NOForma y color:SolidPeso molecular:235.28SB24011
CAS:<p>SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].</p>Fórmula:C34H38N4O7Forma y color:SolidPeso molecular:614.69IKZF1-degrader-2
CAS:<p>IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].</p>Fórmula:C33H30FN5O5Forma y color:SolidPeso molecular:595.62IRAK4 modulator-1
CAS:<p>IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].</p>Fórmula:C19H13ClN4O2Forma y color:SolidPeso molecular:364.79NIK-IN-2
CAS:<p>NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.</p>Fórmula:C20H22N4O3Forma y color:SolidPeso molecular:366.41NLRP3-IN-57
<p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>Fórmula:C44H60O7Forma y color:SolidPeso molecular:700.94Factor B-IN-3
CAS:<p>Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.</p>Fórmula:C24H29N3O4Forma y color:SolidPeso molecular:423.5TBK1/IKKε-IN-1
CAS:<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Fórmula:C28H26N4O5Pureza:98%Forma y color:SolidPeso molecular:498.53
