NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Se han encontrado 385 productos de "NF-κB"
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IMD-biphenylB
CAS:IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.Fórmula:C35H33N5O3Pureza:98%Forma y color:SolidPeso molecular:571.67Xanthine oxidase-IN-6
Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.Fórmula:C29H34N2O15Forma y color:SolidPeso molecular:650.58Avenanthramide-C methyl ester
CAS:Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).Fórmula:C17H15NO6Forma y color:SolidPeso molecular:329.3TRAF-STOP inhibitor 6877002
CAS:TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.Fórmula:C17H17NOPureza:99.76%Forma y color:SolidPeso molecular:251.32Ro 106-9920
CAS:Inhibitor of NF-κB activationFórmula:C10H7N5OSPureza:98%Forma y color:SolidPeso molecular:245.26NF-κB/PON1-IN-1
CAS:NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.Fórmula:C20H16N6O4S2Forma y color:SolidPeso molecular:468.51IMD-catechol
CAS:IMD-catechol: an imidazoquinolinone-based dimer with NF-κB activity; improves CT26 cancer treatment, low toxicity.Fórmula:C31H34N6O3Pureza:98%Forma y color:SolidPeso molecular:538.64GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Fórmula:C22H19N3O5S2Pureza:98.42%Forma y color:SolidPeso molecular:469.53PHA-408
CAS:PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Fórmula:C29H27ClFN7O2Pureza:98%Forma y color:SolidPeso molecular:560.02Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Fórmula:C22H25N3O4Pureza:98%Forma y color:SolidPeso molecular:395.45DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Fórmula:C13H11NO5Pureza:98%Forma y color:SolidPeso molecular:261.23HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Fórmula:C19H16ClN3O3SPureza:98.07% - 98.17%Forma y color:SolidPeso molecular:401.87Ref: TM-T11573
2mg137,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.603,00€200mg2.187,00€TBK1/IKKε-IN-4
CAS:TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nMFórmula:C28H35N7O4Forma y color:SolidPeso molecular:533.62CID-2858522
CAS:CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).Fórmula:C28H39N3O3Pureza:96.12%Forma y color:SolidPeso molecular:465.63Edasalonexent
CAS:Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Fórmula:C31H42N2O3Pureza:99.13% - >99.99%Forma y color:SolidPeso molecular:490.68Ref: TM-T15198
1mg94,00€2mg137,00€5mg222,00€1mL*10mM (DMSO)240,00€10mg356,00€25mg640,00€50mg1.009,00€ABD-350
CAS:ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation.Fórmula:C19H22F2O2Forma y color:SolidPeso molecular:320.37HE 3286
CAS:Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.Fórmula:C21H30O3Forma y color:SolidPeso molecular:330.46NF-κB-IN-3
CAS:NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.Fórmula:C24H18ClF3N2O2Forma y color:SolidPeso molecular:458.86IT-901
CAS:IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.Fórmula:C17H14N2O4SPureza:98.06%Forma y color:SolidPeso molecular:342.37MHY884
CAS:MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.Fórmula:C15H14ClNO3SPureza:98%Forma y color:SolidPeso molecular:323.79
