CCR
Los receptores de quimiocinas C-C (CCRs) son un grupo de GPCR que responden a las quimiocinas, moléculas de señalización que guían la migración de células inmunitarias hacia sitios de inflamación o infección. Los CCR desempeñan un papel crucial en las respuestas inmunitarias, la inflamación y el desarrollo de diversas enfermedades, incluidas las enfermedades autoinmunes y el cáncer. La modulación de la actividad de los CCR se está explorando como una estrategia terapéutica para afecciones como la artritis reumatoide, la esclerosis múltiple y la infección por VIH. En CymitQuimica, ofrecemos una gama de moduladores de CCR de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Se han encontrado 134 productos de "CCR"
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ML604086
CAS:ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.Fórmula:C27H32N4O4SPureza:99.91%Forma y color:SolidPeso molecular:508.63J-113863
CAS:J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).Fórmula:C30H37Cl2IN2O2Pureza:95.11%Forma y color:SolidPeso molecular:655.44Ref: TM-T11699
1mg56,00€2mg82,00€5mg119,00€10mg160,00€25mg288,00€50mg500,00€100mg718,00€1mL*10mM (DMSO)170,00€CCX140
CAS:CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.Fórmula:C20H13ClF3N5O3SPureza:99.66% - 99.95%Forma y color:SolidPeso molecular:495.86Leronlimab
CAS:Leronlimab (PRO 140), a humanized IgG4 monoclonal antibody, targets CCR5 to combat HIV and cancer.Pureza:SDS-PAGE:95.0%;SEC-HPLC:99.6%Forma y color:LiquidPeso molecular:146.66 kDaRS102895 hydrochloride
CAS:RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).Fórmula:C21H22ClF3N2O2Pureza:98.95%Forma y color:SolidPeso molecular:426.86CCR2-RA-[R]
CAS:CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).Fórmula:C18H19ClFNO3Pureza:99.7%Forma y color:SolidPeso molecular:351.8AZ084
CAS:AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.Fórmula:C26H34N4O2Pureza:97.12%Forma y color:SolidPeso molecular:434.57Ref: TM-T10425
1mg84,00€5mg161,00€10mg245,00€25mg406,00€50mg572,00€100mg772,00€200mg1.035,00€1mL*10mM (DMSO)172,00€MK-0812 Succinate
CAS:MK-0812 Succinate is an effective and selective CCR2 antagonist.Fórmula:C28H40F3N3O7Pureza:98.62% - 99.93%Forma y color:SolidPeso molecular:587.63INCB-9471
CAS:INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.Fórmula:C30H40F3N5O2Pureza:98.80%Forma y color:SolidPeso molecular:559.666CKLF1-C27 TFA
CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.Fórmula:C153H244F3N39O39Forma y color:SolidPeso molecular:3310.8CCR8 antagonist 1
CAS:CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Fórmula:C26H29N3O5SPureza:99.51%Forma y color:SolidPeso molecular:495.59BMS-753426
CAS:BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .
Fórmula:C25H33F3N6O2Forma y color:SolidPeso molecular:506.574INCB 3284 dimesylate
CAS:INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.Fórmula:C28H39F3N4O10S2Pureza:98%Forma y color:SolidPeso molecular:712.76SQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Fórmula:C22H26N4O5Forma y color:SolidPeso molecular:426.47Maceneolignan H
CAS:Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.Fórmula:C24H30O7Forma y color:SolidPeso molecular:430.49CCR4 antagonist 3
CAS:Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.Fórmula:C24H27Cl2N7OForma y color:SolidPeso molecular:500.43Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Forma y color:Odour SolidCCR4 antagonist 3 hydrochloride
CAS:Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.Fórmula:C24H27Cl2N7O·xHClForma y color:SolidMLN-3897 TFA
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.Fórmula:C32H32ClF3N2O6Pureza:98.62%Forma y color:SolidPeso molecular:633.05Ref: TM-T28072L
1mg115,00€5mg245,00€10mg363,00€25mg562,00€50mg775,00€100mg1.035,00€200mg1.406,00€1mL*10mM (DMSO)A consultarINCB3344 R-isomer
INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.Fórmula:C29H34F3N3O6Pureza:98%Forma y color:SolidPeso molecular:577.59
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