CCR
Los receptores de quimiocinas C-C (CCRs) son un grupo de GPCR que responden a las quimiocinas, moléculas de señalización que guían la migración de células inmunitarias hacia sitios de inflamación o infección. Los CCR desempeñan un papel crucial en las respuestas inmunitarias, la inflamación y el desarrollo de diversas enfermedades, incluidas las enfermedades autoinmunes y el cáncer. La modulación de la actividad de los CCR se está explorando como una estrategia terapéutica para afecciones como la artritis reumatoide, la esclerosis múltiple y la infección por VIH. En CymitQuimica, ofrecemos una gama de moduladores de CCR de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Se han encontrado 154 productos para "CCR".
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RP-23618
CAS:RP-23618 is a non-peptidic antagonist of RANTES.Fórmula:C30H35N5O3S2Pureza:98%Forma y color:SolidPeso molecular:577.76VCH-286
CAS:VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist.Fórmula:C34H50F2N4O3Pureza:98%Forma y color:SolidPeso molecular:600.78K777
CAS:K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).Fórmula:C32H38N4O4SPureza:98.43% - 99.14%Forma y color:SolidPeso molecular:574.73(1S)-CCR2 antagonist 1
CAS:(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].Fórmula:C28H32BrF3N2OForma y color:SolidPeso molecular:549.47(Rac)-PF-4136309(1341224-83-6 Free base)
CAS:PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for humanFórmula:C29H31F3N6O3Forma y color:SolidPeso molecular:568.59SB-649701
CAS:SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Fórmula:C27H28N4O3Pureza:98%Forma y color:SolidPeso molecular:456.54PF-04634817 succinate
CAS:PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.Fórmula:C29H42F3N5O7Pureza:98%Forma y color:SolidPeso molecular:629.67CMPD167
CAS:CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Fórmula:C35H47FN4O2Pureza:98%Forma y color:SolidPeso molecular:574.77cis-J-113863
CAS:Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].Fórmula:C30H37Cl2IN2O2Forma y color:SolidPeso molecular:655.44CCR4 antagonist 4
CAS:CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].Fórmula:C24H27Cl2N7OForma y color:SolidPeso molecular:500.42CCR3 antagonist 1
CAS:CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Fórmula:C19H21Cl2N3O4S2Pureza:99.02%Forma y color:SolidPeso molecular:490.42Ref: TM-T10156
1mg96,00€5mg178,00€1mL*10mM (DMSO)212,00€10mg289,00€25mg462,00€50mg622,00€100mg837,00€INCB3344
CAS:INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Fórmula:C29H34F3N3O6Pureza:98% - 98.19%Forma y color:SolidPeso molecular:577.59Ref: TM-TQ0103
1mg66,00€5mg144,00€1mL*10mM (DMSO)178,00€10mg230,00€25mg358,00€50mg512,00€100mg707,00€200mg973,00€CP-481715
CAS:CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.Fórmula:C26H31FN4O4Forma y color:SolidPeso molecular:482.55BI 639667
CAS:BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Fórmula:C22H18FN5O3SPureza:99.86%Forma y color:SolidPeso molecular:451.47Aplaviroc
CAS:Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.Fórmula:C33H43N3O6Pureza:98.26% - 99.47%Forma y color:SolidPeso molecular:577.71YM-344031
CAS:YM-344031 is an orally administered antagonist targeting CCR3. It effectively inhibits the binding of Eotaxin-1 and RANTES to CCR3, with IC50 values of 3.0 and 16.3 nM, respectively. YM-344031 also suppresses ligand-induced increases in intracellular Ca [2+] levels and chemotaxis, alters eosinophil morphology induced by eotaxin-1 in macaque blood, and prevents allergic skin reactions in a mouse allergy model.Fórmula:C29H31FN4O3Peso molecular:502.58CP-865569
CAS:CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.Fórmula:C22H26ClFN2O5SForma y color:SolidPeso molecular:484.969MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Fórmula:C24H34F3N3O3Pureza:98%Forma y color:SolidPeso molecular:469.54Nifeviroc
CAS:Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.Fórmula:C33H42N4O6Pureza:98.14%Forma y color:SolidPeso molecular:590.71CCR3 antagonist 2
CAS:CCR3 antagonist2 (example 66) is a CCR3 antagonist useful for researching inflammatory or allergic diseases, particularly those affecting the respiratory tract, such as inflammatory or obstructive airway conditions.Fórmula:C21H28ClN5O3Forma y color:SolidPeso molecular:433.93
