CCR
Los receptores de quimiocinas C-C (CCRs) son un grupo de GPCR que responden a las quimiocinas, moléculas de señalización que guían la migración de células inmunitarias hacia sitios de inflamación o infección. Los CCR desempeñan un papel crucial en las respuestas inmunitarias, la inflamación y el desarrollo de diversas enfermedades, incluidas las enfermedades autoinmunes y el cáncer. La modulación de la actividad de los CCR se está explorando como una estrategia terapéutica para afecciones como la artritis reumatoide, la esclerosis múltiple y la infección por VIH. En CymitQuimica, ofrecemos una gama de moduladores de CCR de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Se han encontrado 165 productos para "CCR".
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Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Fórmula:C30H30Cl2F2N2O8SPureza:99.18%Forma y color:SolidPeso molecular:687.536CMPD167
CAS:CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Fórmula:C35H47FN4O2Pureza:98%Forma y color:SolidPeso molecular:574.77LMD-009
CAS:LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.Fórmula:C29H33N3O3Pureza:98%Forma y color:SolidPeso molecular:471.5906trans-J-113863
CAS:Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].Fórmula:C30H37Cl2IN2O2Forma y color:SolidPeso molecular:655.44PF-04634817
CAS:PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Fórmula:C25H36F3N5O3Pureza:98%Forma y color:SolidPeso molecular:511.58K777
CAS:K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).Fórmula:C32H38N4O4SPureza:98.43% - 99.74%Forma y color:SolidPeso molecular:574.734VCH-286
CAS:VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist.Fórmula:C34H50F2N4O3Pureza:98%Forma y color:SolidPeso molecular:600.78AZD2423
CAS:AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFórmula:C20H29ClFN5O2Pureza:98%Forma y color:SolidPeso molecular:425.928cis-J-113863
CAS:Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].Fórmula:C30H37Cl2IN2O2Forma y color:SolidPeso molecular:655.44(1S)-CCR2 antagonist 1
CAS:(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].Fórmula:C28H32BrF3N2OForma y color:SolidPeso molecular:549.47BMS-639623
CAS:BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.Fórmula:C25H32FN7O2Forma y color:SolidPeso molecular:481.57SB-649701
CAS:SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Fórmula:C27H28N4O3Pureza:98%Forma y color:SolidPeso molecular:456.54(Rac)-PF-4136309
CAS:PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for humanFórmula:C29H31F3N6O3Forma y color:SolidPeso molecular:568.59PF-04634817 succinate
CAS:PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.Fórmula:C29H42F3N5O7Pureza:98%Forma y color:SolidPeso molecular:629.67RP-23618
CAS:RP-23618 is a non-peptidic antagonist of RANTES.Fórmula:C30H35N5O3S2Pureza:98%Forma y color:SolidPeso molecular:577.76CCR4 antagonist 4
CAS:CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].Fórmula:C24H27Cl2N7OForma y color:SolidPeso molecular:500.42CCR2 antagonist 4
CAS:CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFórmula:C21H21ClF3N3O2Pureza:99.86%Forma y color:SolidPeso molecular:439.86MLN-3897
CAS:MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Fórmula:C30H31ClN2O4Pureza:98.62%Forma y color:SolidPeso molecular:519.03CCR3 antagonist 1
CAS:CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Fórmula:C19H21Cl2N3O4S2Pureza:99.02%Forma y color:SolidPeso molecular:490.424INCB3344
CAS:INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Fórmula:C29H34F3N3O6Pureza:98.19% - 99.61%Forma y color:SolidPeso molecular:577.592
