CCR
Los receptores de quimiocinas C-C (CCRs) son un grupo de GPCR que responden a las quimiocinas, moléculas de señalización que guían la migración de células inmunitarias hacia sitios de inflamación o infección. Los CCR desempeñan un papel crucial en las respuestas inmunitarias, la inflamación y el desarrollo de diversas enfermedades, incluidas las enfermedades autoinmunes y el cáncer. La modulación de la actividad de los CCR se está explorando como una estrategia terapéutica para afecciones como la artritis reumatoide, la esclerosis múltiple y la infección por VIH. En CymitQuimica, ofrecemos una gama de moduladores de CCR de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Se han encontrado 154 productos para "CCR".
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CKLF1-C27 TFA
CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.Fórmula:C153H244F3N39O39Forma y color:SolidPeso molecular:3310.8CCR8 antagonist 1
CAS:CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Fórmula:C26H29N3O5SPureza:99.51%Forma y color:SolidPeso molecular:495.59TBK1 degrader-4
TBK1degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. It effectively inhibits cyst growth, reduces inflammation, and lowers levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1degrader-4 shows potential for research in autosomal dominant polycystic kidney disease (ADPKD).Forma y color:Odour SolidBMS-753426
CAS:BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .Fórmula:C25H33F3N6O2Forma y color:SolidPeso molecular:506.574CMKLR1 antagonist 1
CMKLR1 antagonist 1 (compound S-26d) is a potent, orally active antagonist of the chemokine-like receptor 1 (CMKLR1), exhibiting a pIC50 of 7.44 in hCMKLR1-Forma y color:Odour SolidINCB10820
CAS:INCB10820 is an efficient and specific dual antagonist of CCR2 and CCR5, with oral bioavailability.Fórmula:C25H37F3N4O3Peso molecular:498.58CCR2 antagonist 1
CAS:CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).Fórmula:C28H32BrF3N2OForma y color:SolidPeso molecular:549.47LM-108
LM-108 is a monoclonal antibody that targets CCR8. It selectively eliminates tumor-infiltrating regulatory T cells (Treg) and is applicable to gastric cancer research.Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Forma y color:Odour SolidINCB3344 R-isomer
INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.Fórmula:C29H34F3N3O6Pureza:98%Forma y color:SolidPeso molecular:577.59RS102895
CAS:RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.Fórmula:C21H21F3N2O2Pureza:97.64% - 99.80%Forma y color:SolidPeso molecular:390.4RE-640
CAS:NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Fórmula:C20H16Cl2N4Pureza:99.60% - 99.87%Forma y color:White SolidPeso molecular:383.27RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Fórmula:C25H27N3O3Pureza:98.64% - 99.68%Forma y color:SolidPeso molecular:417.5Vercirnon sodium
CAS:Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.Fórmula:C22H21ClN2NaO4SForma y color:SolidPeso molecular:467.92ZK 756326
CAS:ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.Fórmula:C21H28N2O3Pureza:99.43%Forma y color:White SolidPeso molecular:356.46BX471
CAS:BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Fórmula:C21H24ClFN4O3Pureza:98% - 99.98%Forma y color:SolidPeso molecular:434.89Ref: TM-T2375
1mg35,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg117,00€25mg200,00€50mg313,00€100mg489,00€200mg740,00€PF-4136309
CAS:PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Fórmula:C29H31F3N6O3Pureza:98.85% - 99.47%Forma y color:SolidPeso molecular:568.59Vicriviroc
CAS:Vicriviroc, also known as MK4176 is a CCR5 antagonist.Fórmula:C28H38F3N5O2Forma y color:SolidPeso molecular:533.637,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Fórmula:C15H10O4Pureza:99.39% - 99.6%Forma y color:White SolidPeso molecular:254.24C-021
CAS:C 021 dihydrochloride is a potent CCR4 antagonist.Fórmula:C27H41N5O2Pureza:99.74% - 99.90%Forma y color:White SolidPeso molecular:467.65Ref: TM-T21870
1mg49,00€2mg67,00€5mg90,00€1mL*10mM (DMSO)90,00€10mg144,00€25mg286,00€50mg444,00€100mg622,00€
