CCR
Los receptores de quimiocinas C-C (CCRs) son un grupo de GPCR que responden a las quimiocinas, moléculas de señalización que guían la migración de células inmunitarias hacia sitios de inflamación o infección. Los CCR desempeñan un papel crucial en las respuestas inmunitarias, la inflamación y el desarrollo de diversas enfermedades, incluidas las enfermedades autoinmunes y el cáncer. La modulación de la actividad de los CCR se está explorando como una estrategia terapéutica para afecciones como la artritis reumatoide, la esclerosis múltiple y la infección por VIH. En CymitQuimica, ofrecemos una gama de moduladores de CCR de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Se han encontrado 136 productos de "CCR"
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Vercirnon
CAS:<p>Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.</p>Fórmula:C22H21ClN2O4SPureza:99.23%Forma y color:SolidPeso molecular:444.93Maraviroc
CAS:<p>Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s—MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.</p>Fórmula:C29H41F2N5OPureza:97.13% - 99.59%Forma y color:Brown SolidPeso molecular:513.67C-021
CAS:<p>C 021 dihydrochloride is a potent CCR4 antagonist.</p>Fórmula:C27H41N5O2Pureza:99.74% - 99.90%Forma y color:SolidPeso molecular:467.65R243
CAS:<p>R243 is CCR8 signaling and chemotaxis inhibitor.</p>Fórmula:C21H27NO4Pureza:99.03%Forma y color:SolidPeso molecular:357.44RE-640
CAS:<p>NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.</p>Fórmula:C20H16Cl2N4Pureza:99.60% - 99.87%Forma y color:SolidPeso molecular:383.27Vicriviroc maleate
CAS:<p>Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.</p>Fórmula:C32H42F3N5O6Pureza:98.16% - 98.37%Forma y color:SolidPeso molecular:649.7BX471
CAS:<p>BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.</p>Fórmula:C21H24ClFN4O3Pureza:98% - 99.94%Forma y color:SolidPeso molecular:434.89SB297006
CAS:<p>SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.</p>Fórmula:C18H18N2O5Pureza:99.59%Forma y color:SolidPeso molecular:342.35Bindarit
CAS:<p>Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.</p>Fórmula:C19H20N2O3Pureza:98.35% - 98.55%Forma y color:SolidPeso molecular:324.377,4'-Dihydroxyflavone
CAS:<p>7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.</p>Fórmula:C15H10O4Pureza:99.39% - 99.6%Forma y color:SolidPeso molecular:254.24RS 504393
CAS:<p>RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).</p>Fórmula:C25H27N3O3Pureza:98.64% - 99.62%Forma y color:SolidPeso molecular:417.5BMS-813160
CAS:<p>BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.</p>Fórmula:C25H40N8O2Pureza:99.66% - 99.79%Forma y color:SolidPeso molecular:484.64DAPTA
CAS:<p>DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.</p>Fórmula:C35H56N10O15Pureza:>99.99%Forma y color:SolidPeso molecular:856.88Vercirnon sodium
CAS:<p>Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.</p>Fórmula:C22H21ClN2NaO4SForma y color:SolidPeso molecular:467.92AZD2098
CAS:<p>AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.</p>Fórmula:C11H9Cl2N3O3SPureza:99.80% - >99.99%Forma y color:SolidPeso molecular:334.18Cenicriviroc
CAS:<p>Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.</p>Fórmula:C41H52N4O4SPureza:97.87%Forma y color:SolidPeso molecular:696.94INCB 3284
CAS:<p>INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.</p>Fórmula:C26H31F3N4O4Pureza:97.81% - 99.42%Forma y color:SolidPeso molecular:520.54Carlumab
CAS:<p>Carlumab is a high-affinity human monoclonal antibody that targets CCL2, suppressing the recruitment of monocytes/macrophages in the tumour microenvironment.</p>Pureza:95%Forma y color:LiquidTivumecirnon
CAS:<p>Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumour</p>Fórmula:C24H27Cl2F3N6OPureza:99.88%Forma y color:SolidPeso molecular:543.41BI-6901
CAS:<p>BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.</p>Fórmula:C23H27N5O3SPureza:99.83%Forma y color:SolidPeso molecular:453.56CCR4 antagonist 3-1
CAS:<p>CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.</p>Fórmula:C14H12N2SPureza:99.53%Forma y color:SolidPeso molecular:240.32CCR1 antagonist 9
CAS:<p>CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. CCR1 inhibition in calcium flux assays.</p>Fórmula:C20H16FN5O3SPureza:99.13%Forma y color:SolidPeso molecular:425.44CCR8 antagonist 2
CAS:<p>CCR8 antagonist 2 blocks CCR8 activity, mainly on Treg and Th2 cells, for treating related diseases. See WO2022000443A1, compound 220.</p>Fórmula:C23H30ClN3O3SForma y color:SolidPeso molecular:464.02YM022
CAS:<p>YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.</p>Fórmula:C32H28N4O3Pureza:98%Forma y color:SolidPeso molecular:516.59CCR2 antagonist 3
CAS:<p>CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.</p>Fórmula:C17H25FN2O2Pureza:99.87%Forma y color:SolidPeso molecular:308.39GW 766994
CAS:<p>GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.</p>Fórmula:C21H24Cl2N4O3Pureza:98.77%Forma y color:SolidPeso molecular:451.35CCR1 antagonist 7
CAS:<p>CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].</p>Fórmula:C21H24ClN5O3SPureza:98%Forma y color:SolidPeso molecular:461.96RPT193
CAS:<p>RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.</p>Fórmula:C27H34Cl3N5O2Forma y color:SolidPeso molecular:566.95ALK4290
CAS:<p>ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.</p>Fórmula:C27H34ClN5O3Forma y color:SolidPeso molecular:512.04CCX354
CAS:<p>CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.</p>Fórmula:C22H22ClN7O2Pureza:99.82% - 99.82%Forma y color:SolidPeso molecular:451.91PNU-177864 hydrochloride
CAS:<p>PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.</p>Fórmula:C18H22ClF3N2O3SPureza:99.95%Forma y color:SolidPeso molecular:438.89PNU-177864
CAS:<p>PNU-177864 is a selective dopamine D3 receptor antagonist.</p>Fórmula:C18H21F3N2O3SPureza:99.92%Forma y color:SolidPeso molecular:402.43BMS-457
CAS:<p>BMS-457 is a potent, CCR1-selective antagonist.</p>Fórmula:C24H35ClN2O4Pureza:98%Forma y color:SolidPeso molecular:451AZD-1678
CAS:<p>AZD-1678 is a potent CCR4 receptor antagonist.</p>Fórmula:C11H8Cl2FN3O3SForma y color:SolidPeso molecular:352.17MLN3126
CAS:<p>MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.</p>Fórmula:C21H19ClN2O5SForma y color:SolidPeso molecular:446.9JNJ-27141491
CAS:<p>JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.</p>Fórmula:C17H15F2N3O3SPureza:98%Forma y color:SolidPeso molecular:379.38TAK-220
CAS:<p>TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).</p>Fórmula:C31H41ClN4O3Pureza:98%Forma y color:SolidPeso molecular:553.14C-021 dihydrochloride
CAS:<p>C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.</p>Fórmula:C27H43Cl2N5O2Pureza:98.67%Forma y color:SolidPeso molecular:540.57CCR1 antagonist 6
CAS:<p>CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).</p>Fórmula:C21H23ClN4O3SPureza:99.02% - 99.15%Forma y color:SolidPeso molecular:446.95Ancriviroc
CAS:<p>Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.</p>Fórmula:C28H37BrN4O3Pureza:99.76% - 99.82%Forma y color:SolidPeso molecular:557.52BMS CCR2 22
CAS:<p>BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.</p>Fórmula:C28H34F3N5O4SPureza:99.65%Forma y color:SolidPeso molecular:593.66CCR2 antagonist 5
CAS:<p>JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.</p>Fórmula:C22H25F3N4O3SPureza:99.09%Forma y color:SolidPeso molecular:482.52BMS-817399
CAS:<p>BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.</p>Fórmula:C23H36ClN3O4Pureza:99.7%Forma y color:SolidPeso molecular:454SB 328437
CAS:<p>SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).</p>Fórmula:C21H18N2O5Pureza:99.54%Forma y color:SolidPeso molecular:378.38Cosalane
CAS:<p>Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.</p>Fórmula:C45H60Cl2O6Pureza:99.53% - 99.78%Forma y color:SolidPeso molecular:767.86GSK2239633A
CAS:<p>GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.</p>Fórmula:C24H25ClN4O5S2Pureza:99.82%Forma y color:SolidPeso molecular:549.06VCH-286
CAS:<p>VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist.</p>Fórmula:C34H50F2N4O3Pureza:98%Forma y color:SolidPeso molecular:600.78PF-04634817 succinate
CAS:<p>PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.</p>Fórmula:C29H42F3N5O7Pureza:98%Forma y color:SolidPeso molecular:629.67CCR2 antagonist 4
CAS:<p>CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM</p>Fórmula:C21H21ClF3N3O2Pureza:99.86%Forma y color:SolidPeso molecular:439.86CCR4 antagonist 4
CAS:<p>CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].</p>Fórmula:C24H27Cl2N7OForma y color:SolidPeso molecular:500.42
