CCR
Los receptores de quimiocinas C-C (CCRs) son un grupo de GPCR que responden a las quimiocinas, moléculas de señalización que guían la migración de células inmunitarias hacia sitios de inflamación o infección. Los CCR desempeñan un papel crucial en las respuestas inmunitarias, la inflamación y el desarrollo de diversas enfermedades, incluidas las enfermedades autoinmunes y el cáncer. La modulación de la actividad de los CCR se está explorando como una estrategia terapéutica para afecciones como la artritis reumatoide, la esclerosis múltiple y la infección por VIH. En CymitQuimica, ofrecemos una gama de moduladores de CCR de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Se han encontrado 136 productos de "CCR"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
PF-4136309
CAS:<p>PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.</p>Fórmula:C29H31F3N6O3Pureza:98.85% - 99.47%Forma y color:SolidPeso molecular:568.59Vercirnon sodium
CAS:Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.Fórmula:C22H21ClN2NaO4SForma y color:SolidPeso molecular:467.92TAK-779
CAS:<p>TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).</p>Fórmula:C33H39ClN2O2Pureza:99.21%Forma y color:SolidPeso molecular:531.13Cenicriviroc
CAS:<p>Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.</p>Fórmula:C41H52N4O4SPureza:97.87%Forma y color:SolidPeso molecular:696.94ZK 756326
CAS:<p>ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.</p>Fórmula:C21H28N2O3Pureza:99.43%Forma y color:SolidPeso molecular:356.46INCB 3284
CAS:INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.Fórmula:C26H31F3N4O4Pureza:97.81% - 99.42%Forma y color:SolidPeso molecular:520.54Carlumab
CAS:<p>Carlumab is a high-affinity human monoclonal antibody that targets CCL2, suppressing the recruitment of monocytes/macrophages in the tumour microenvironment.</p>Pureza:95%Forma y color:LiquidTivumecirnon
CAS:<p>Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumour</p>Fórmula:C24H27Cl2F3N6OPureza:99.88%Forma y color:SolidPeso molecular:543.41CCR8 antagonist 2
CAS:<p>CCR8 antagonist 2 blocks CCR8 activity, mainly on Treg and Th2 cells, for treating related diseases. See WO2022000443A1, compound 220.</p>Fórmula:C23H30ClN3O3SForma y color:SolidPeso molecular:464.02JNJ-27141491
CAS:<p>JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.</p>Fórmula:C17H15F2N3O3SPureza:98%Forma y color:SolidPeso molecular:379.38BI-6901
CAS:<p>BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.</p>Fórmula:C23H27N5O3SPureza:99.83%Forma y color:SolidPeso molecular:453.56PNU-177864
CAS:<p>PNU-177864 is a selective dopamine D3 receptor antagonist.</p>Fórmula:C18H21F3N2O3SPureza:99.92%Forma y color:SolidPeso molecular:402.43GW 766994
CAS:<p>GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.</p>Fórmula:C21H24Cl2N4O3Pureza:98.77%Forma y color:SolidPeso molecular:451.35MLN3126
CAS:<p>MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.</p>Fórmula:C21H19ClN2O5SForma y color:SolidPeso molecular:446.9CCR1 antagonist 7
CAS:<p>CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].</p>Fórmula:C21H24ClN5O3SPureza:98%Forma y color:SolidPeso molecular:461.96TAK-220
CAS:<p>TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).</p>Fórmula:C31H41ClN4O3Pureza:98%Forma y color:SolidPeso molecular:553.14CCX354
CAS:<p>CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.</p>Fórmula:C22H22ClN7O2Pureza:99.82% - 99.82%Forma y color:SolidPeso molecular:451.91BMS-457
CAS:<p>BMS-457 is a potent, CCR1-selective antagonist.</p>Fórmula:C24H35ClN2O4Pureza:98%Forma y color:SolidPeso molecular:451C-021 dihydrochloride
CAS:<p>C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.</p>Fórmula:C27H43Cl2N5O2Pureza:98.67%Forma y color:SolidPeso molecular:540.57CCR4 antagonist 3-1
CAS:<p>CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.</p>Fórmula:C14H12N2SPureza:99.53%Forma y color:SolidPeso molecular:240.32
