CCR
Los receptores de quimiocinas C-C (CCRs) son un grupo de GPCR que responden a las quimiocinas, moléculas de señalización que guían la migración de células inmunitarias hacia sitios de inflamación o infección. Los CCR desempeñan un papel crucial en las respuestas inmunitarias, la inflamación y el desarrollo de diversas enfermedades, incluidas las enfermedades autoinmunes y el cáncer. La modulación de la actividad de los CCR se está explorando como una estrategia terapéutica para afecciones como la artritis reumatoide, la esclerosis múltiple y la infección por VIH. En CymitQuimica, ofrecemos una gama de moduladores de CCR de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Se han encontrado 154 productos para "CCR".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
AZD-1678
CAS:AZD-1678 is a potent CCR4 receptor antagonist.Fórmula:C11H8Cl2FN3O3SForma y color:SolidPeso molecular:352.17BI-6901
CAS:BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Fórmula:C23H27N5O3SPureza:99.83% - 99.98%Forma y color:White SolidPeso molecular:453.56Ref: TM-T36478
1mg117,00€5mg281,00€1mL*10mM (DMSO)310,00€10mg447,00€25mg827,00€50mg1.108,00€100mg1.494,00€ALK4290
CAS:ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.Fórmula:C27H34ClN5O3Forma y color:SolidPeso molecular:512.04AF-399/42018025
CAS:AF-399/42018025 is a small-molecule CCR4 antagonist applied to investigate chemokine-mediated immune cell trafficking and inflammatory disease mechanisms.Fórmula:C26H16ClN3O4S3Pureza:99.96%Forma y color:Yellow SolidPeso molecular:566.07CCR2 antagonist 5
CAS:JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Fórmula:C22H25F3N4O3SPureza:99.98%Forma y color:SolidPeso molecular:482.52BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Fórmula:C28H34F3N5O4SPureza:99.65%Forma y color:SolidPeso molecular:593.66Ref: TM-T14688
1mg55,00€5mg110,00€1mL*10mM (DMSO)141,00€10mg173,00€25mg349,00€50mg532,00€100mg718,00€200mg964,00€Ancriviroc
CAS:Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.Fórmula:C28H37BrN4O3Pureza:99.76% - 99.82%Forma y color:SolidPeso molecular:557.533SB 328437
CAS:SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Fórmula:C21H18N2O5Pureza:99.54%Forma y color:SolidPeso molecular:378.38Ref: TM-T23321
1mg39,00€1mL*10mM (DMSO)69,00€5mg82,00€10mg123,00€25mg250,00€50mg394,00€100mg618,00€200mg874,00€CCR1 antagonist 6
CAS:CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).Fórmula:C21H23ClN4O3SPureza:99.15% - 99.92%Forma y color:SolidPeso molecular:446.95Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Fórmula:C30H30Cl2F2N2O8SPureza:99.18%Forma y color:SolidPeso molecular:687.54Cosalane
CAS:Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.Fórmula:C45H60Cl2O6Pureza:99.53% - 99.78%Forma y color:White SolidPeso molecular:767.86GSK2239633A
CAS:GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Fórmula:C24H25ClN4O5S2Pureza:99.82%Forma y color:White SolidPeso molecular:549.06Ref: TM-T11481
500mgA consultar1mg35,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg118,00€25mg245,00€50mg355,00€100mg515,00€BMS-817399
CAS:BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.Fórmula:C23H36ClN3O4Pureza:99.7%Forma y color:SolidPeso molecular:454Ref: TM-T26861
1mg92,00€5mg192,00€1mL*10mM (DMSO)215,00€10mg290,00€25mg462,00€50mg622,00€100mg837,00€PF-04634817
CAS:PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Fórmula:C25H36F3N5O3Pureza:98%Forma y color:SolidPeso molecular:511.58BMS-639623
CAS:BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.Fórmula:C25H32FN7O2Forma y color:SolidPeso molecular:481.57MLN-3897
CAS:MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Fórmula:C30H31ClN2O4Pureza:98.62%Forma y color:SolidPeso molecular:519.03AZD2423
CAS:AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFórmula:C20H29ClFN5O2Pureza:98%Forma y color:SolidPeso molecular:425.93trans-J-113863
CAS:Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].Fórmula:C30H37Cl2IN2O2Forma y color:SolidPeso molecular:655.44LMD-009
CAS:LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.Fórmula:C29H33N3O3Pureza:98%Forma y color:SolidPeso molecular:471.59CCR2 antagonist 4
CAS:CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFórmula:C21H21ClF3N3O2Pureza:99.86%Forma y color:SolidPeso molecular:439.86
