TLR
Los receptores tipo Toll (TLR) son una clase de proteínas que desempeñan un papel crítico en el sistema inmunitario innato al reconocer patrones moleculares asociados a patógenos (PAMP) e iniciar respuestas inmunitarias. Los TLR están involucrados en la detección de una amplia gama de patógenos, incluidos bacterias, virus y hongos, y son esenciales para la activación de las vías de señalización inflamatorias. La desregulación de la señalización de los TLR se asocia con enfermedades inflamatorias crónicas, trastornos autoinmunes y cáncer. En CymitQuimica, ofrecemos una variedad de moduladores de TLR de alta calidad para apoyar su investigación en inmunidad innata, inflamación y enfermedades infecciosas.
Se han encontrado 76 productos de "TLR"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
BMS-905
CAS:BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Fórmula:C23H29N3Pureza:99.94%Forma y color:SoildPeso molecular:347.5IAXO-102
CAS:IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.Fórmula:C35H71NO5Pureza:98.17%Forma y color:SolidPeso molecular:585.94CU-CPT22
CAS:CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Fórmula:C19H22O7Pureza:98.66% - 99.80%Forma y color:SolidPeso molecular:362.37TLR7/8 agonist 3
CAS:<p>TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.</p>Fórmula:C17H23N5OPureza:99.84%Forma y color:SolidPeso molecular:313.4CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Fórmula:C17H13F3N4O2Pureza:99.84%Forma y color:SolidPeso molecular:362.31CU-CPT17e
CAS:CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Fórmula:C27H24N2O8Pureza:98.49%Forma y color:SolidPeso molecular:504.49Pam3CSK4-Biotin
CAS:Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Fórmula:C103H192N14O17S2Pureza:98%Forma y color:SolidPeso molecular:1962.85Tilsotolimod sodium
CAS:Tilsotolimod sodium, a synthetic Toll-like receptor 9 (TLR9) agonist, has shown antitumor activity in preclinical models.Fórmula:C223H262N74Na22O115P22S22Forma y color:SolidPeso molecular:7711.51ODN 4084-F
CAS:ODN 4084-F, a class B ('broadly-active') inhibitory ODN, is a potent inhibitor of TLR9-induced B cells and macrophages.Forma y color:SolidTLR7 agonist 17
CAS:TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Fórmula:C25H37N7O3Forma y color:SolidPeso molecular:483.61Tomaralimab
CAS:<p>Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).</p>Pureza:100% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:145.32 kDaL07-2
CAS:L07-2 (Compound 6) is an active scaffold that includes a TLR7/8 agonist. It is suitable for the synthesis of immune-stimulating antibody conjugates (ISACs) used in cancer research.Fórmula:C56H83N15O14Forma y color:SolidPeso molecular:1190.35MTvkPABC-P5 TFA
MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).Forma y color:Odour SolidPam2CSK4
CAS:<p>TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.</p>Fórmula:C65H126N10O12SPureza:98%Forma y color:SolidPeso molecular:1271.83TLR8 agonist 7
CAS:TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.Fórmula:C54H63N9O16Forma y color:SolidPeso molecular:1094.13CRX 527
CAS:CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.Fórmula:C81H151N2O19PForma y color:SolidPeso molecular:1488.04Ezeprogind
CAS:<p>Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can Trust</p>Fórmula:C25H44N6Pureza:99.28%Forma y color:SolidPeso molecular:428.66TLR7/8 agonist 12
<p>TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.</p>Fórmula:C29H38N6O3Forma y color:SolidPeso molecular:518.65TLR8 agonist 8
CAS:TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Fórmula:C53H63N11O10Forma y color:SolidPeso molecular:1014.14PVP-037.2
CAS:PVP-037.2 is a TLR7/8 agonist that acts as an adjuvant to enhance vaccine-induced TH1 immune responses and boost the production of antigen-specific antibodies IgG1 and IgG2c.Fórmula:C23H20F3N5OForma y color:SoildPeso molecular:439.43
