STAT
Las proteínas STAT son componentes críticos de la vía de señalización JAK/STAT, que transmite señales extracelulares de citoquinas y factores de crecimiento al núcleo celular, influyendo en la expresión génica. Las proteínas STAT están involucradas en la regulación de respuestas inmunitarias, crecimiento celular, diferenciación y supervivencia. La desregulación de la señalización STAT está implicada en diversas enfermedades, incluido el cáncer, trastornos autoinmunes e inflamación crónica. En CymitQuimica, ofrecemos una amplia gama de moduladores de la vía STAT para apoyar su investigación en transducción de señales, inmunología y desarrollo terapéutico.
Se han encontrado 98 productos de "STAT"
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Artesunate
CAS:<p>Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.</p>Fórmula:C19H28O8Pureza:97.67% - 99.9%Forma y color:White Crystalline PowderPeso molecular:384.42Fludarabine
CAS:<p>Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.</p>Fórmula:C10H12FN5O4Pureza:99.65% - 99.89%Forma y color:White SolidPeso molecular:285.23STAT3-IN-1
CAS:<p>STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor</p>Fórmula:C28H29NO6Pureza:95.89% - 95.89%Forma y color:SolidPeso molecular:475.53Diosgenin
CAS:<p>Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.</p>Fórmula:C27H42O3Pureza:98.87% - 99.87%Forma y color:Flaky Or Needle CrystalPeso molecular:414.62L002
CAS:<p>L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.</p>Fórmula:C15H15NO5SPureza:98.59%Forma y color:SolidPeso molecular:321.35Nifuroxazide
CAS:<p>Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.</p>Fórmula:C12H9N3O5Pureza:99.79% - 99.95%Forma y color:Yellow SolidPeso molecular:275.22Niclosamide olamine
CAS:<p>Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.</p>Fórmula:C15H15Cl2N3O5Pureza:99.89%Forma y color:Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Peso molecular:388.20UC-514321
CAS:<p>UC-514321 directly targets STAT3/5 and represses TET1 expression.</p>Fórmula:C26H35NO5Pureza:98.50%Forma y color:SolidPeso molecular:441.56Garcinone C
CAS:<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Fórmula:C23H26O7Pureza:99.13% - 99.92%Forma y color:SolidPeso molecular:414.45Niclosamide
CAS:<p>Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.</p>Fórmula:C13H8Cl2N2O4Pureza:98.47% - 99.1%Forma y color:Pale Yellow Crystals SolidPeso molecular:327.12STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Fórmula:C22H30F3NO7Forma y color:SolidPeso molecular:477.471Eflepedocokin alfa
CAS:<p>Eflepedocokin alfa is a recombinant IL-22/IgG2-Fc protein, potentially protecting cells and enhancing immune function and tissue repair.</p>Forma y color:LiquidSTAT4-IN-1
<p>STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.</p>Forma y color:Odour SolidNeocucurbitacin A
CAS:<p>Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].</p>Fórmula:C31H42O8Pureza:98%Forma y color:SolidPeso molecular:542.66STAT3-IN-39
CAS:<p>STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.</p>Fórmula:C20H17F3N2O3SForma y color:SolidPeso molecular:422.42(R)-Lisofylline
CAS:<p>(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).</p>Fórmula:C13H20N4O3Pureza:99.50%Forma y color:SolidPeso molecular:280.32JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Forma y color:Odour SolidSTAT3 HiBiT degrader 1
CAS:<p>STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.</p>Fórmula:C58H63F4N10O14PSForma y color:SolidPeso molecular:1263.21Anticancer agent 259
<p>Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.</p>Fórmula:C30H26N2O2Forma y color:SolidPeso molecular:446.54CMD178
<p>CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.</p>Fórmula:C46H59N9O7Pureza:98%Forma y color:SolidPeso molecular:850.03STAT3-IN-37
CAS:<p>STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.</p>Fórmula:C23H25Cl2N5O2Forma y color:SolidPeso molecular:474.38Eupalinolide K
CAS:<p>Eupalinolide K is a natural product</p>Fórmula:C20H26O6Pureza:98%Forma y color:SolidPeso molecular:362.42STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Fórmula:C25H27N5OForma y color:SolidPeso molecular:413.51STX-0119
CAS:<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Fórmula:C22H14N4O3Pureza:99.61%Forma y color:SolidPeso molecular:382.37STAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Fórmula:C16H15NO3SForma y color:SolidPeso molecular:301.36STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Fórmula:C19H16N2O4SForma y color:SolidPeso molecular:368.41MNK8
CAS:<p>MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.</p>Fórmula:C15H12N2O2Pureza:99.74%Forma y color:SolidPeso molecular:252.27Stafib-1
CAS:<p>Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.</p>Fórmula:C26H24N2O11P2Pureza:97.18%Forma y color:SolidPeso molecular:602.42Balsalazide
CAS:<p>Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.</p>Fórmula:C17H15N3O6Pureza:99.31%Forma y color:Yellow To Orange Crystalline PowderPeso molecular:357.32SC-43
CAS:<p>SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).</p>Fórmula:C21H13ClF3N3O2Pureza:98.44%Forma y color:SolidPeso molecular:431.8SH-4-54
CAS:SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.Fórmula:C29H27F5N2O5SPureza:98% - 99.12%Forma y color:SolidPeso molecular:610.59SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Fórmula:C15H8Cl2FN3OPureza:99.56%Forma y color:SolidPeso molecular:336.15Pimozide
CAS:<p>Pimozide: antipsychotic that blocks type 2 dopamine, alpha-adrenergic, and 5-HT2 receptors, reducing tics and delusions.</p>Fórmula:C28H29F2N3OPureza:99.63% - >99.99%Forma y color:SolidPeso molecular:461.55WP1066
CAS:<p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>Fórmula:C17H14BrN3OPureza:98.92% - 99.73%Forma y color:SolidPeso molecular:356.22Cucurbitacin I
CAS:<p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>Fórmula:C30H42O7Pureza:96.69% - 99.8%Forma y color:SolidPeso molecular:514.65RSVA405
CAS:<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Fórmula:C17H20N4O2Pureza:99.30%Forma y color:SolidPeso molecular:312.37Cryptotanshinone
CAS:<p>Cryptotanshinone: STAT3 inhibitor, IC50 4.6 μM; blocks STAT3 Tyr705 phosphorylation, minor effect on Ser727, no impact on STAT1/5.</p>Fórmula:C19H20O3Pureza:97.94% - ≥95%Forma y color:Orange Needle CrystalPeso molecular:296.36Scutellarin
CAS:<p>Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.</p>Fórmula:C21H18O12Pureza:97.12% - 99.75%Forma y color:SolidPeso molecular:462.36Brevilin A
CAS:<p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>Fórmula:C20H26O5Pureza:99.97% - >99.99%Forma y color:SolidPeso molecular:346.42AS2863619
CAS:<p>AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.</p>Fórmula:C16H14Cl2N8OPureza:>99.99%Forma y color:SolidPeso molecular:405.24Atranorin
CAS:<p>Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.</p>Fórmula:C19H18O8Pureza:98.76% - 99.57%Forma y color:SolidPeso molecular:374.34HO-3867
CAS:<p>HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.</p>Fórmula:C28H30F2N2O2Pureza:91.18% - 99.21%Forma y color:SolidPeso molecular:464.55S3I-201
CAS:<p>S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.</p>Fórmula:C16H15NO7SPureza:97.83%Forma y color:SolidPeso molecular:365.36Morusin
CAS:<p>Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.</p>Fórmula:C25H24O6Pureza:98.68% - 99.8%Forma y color:SolidPeso molecular:420.45STAT5-IN-1
CAS:<p>STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.</p>Fórmula:C16H11N3O3Pureza:99.44% - ≥95%Forma y color:SolidPeso molecular:293.28Napabucasin
CAS:<p>Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.</p>Fórmula:C14H8O4Pureza:98.43% - 99.85%Forma y color:SolidPeso molecular:240.21Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Fórmula:C19H24O5Pureza:96.66%Forma y color:SolidPeso molecular:332.39Garcinone D
CAS:<p>Garcinone D is cytotoxic to CEM-SS cells (IC50=3.2 µg/ml), inhibits aromatase and p65 activation (IC50=3.2 µM).</p>Fórmula:C24H28O7Pureza:99.94%Forma y color:SolidPeso molecular:428.47Triacetylresveratrol
CAS:<p>Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.</p>Fórmula:C20H18O6Pureza:99.81%Forma y color:Off White PowderPeso molecular:354.35HJC0152 hydrochloride
CAS:<p>HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.</p>Fórmula:C15H14Cl3N3O4Pureza:99.01% - 99.06%Forma y color:SolidPeso molecular:406.64
