STAT
Las proteínas STAT son componentes críticos de la vía de señalización JAK/STAT, que transmite señales extracelulares de citoquinas y factores de crecimiento al núcleo celular, influyendo en la expresión génica. Las proteínas STAT están involucradas en la regulación de respuestas inmunitarias, crecimiento celular, diferenciación y supervivencia. La desregulación de la señalización STAT está implicada en diversas enfermedades, incluido el cáncer, trastornos autoinmunes e inflamación crónica. En CymitQuimica, ofrecemos una amplia gama de moduladores de la vía STAT para apoyar su investigación en transducción de señales, inmunología y desarrollo terapéutico.
Se han encontrado 108 productos para "STAT".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
STAT3-IN-20
CAS:STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFórmula:C30H27F4N7SPureza:98%Forma y color:SolidPeso molecular:593.64STAT6-IN-2
CAS:STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.Fórmula:C28H31N5O2Pureza:99.94%Forma y color:SolidPeso molecular:469.58STAT3-IN-35
CAS:STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.Fórmula:C21H23NO4Forma y color:SolidPeso molecular:353.41WZ-2-033
CAS:WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.Fórmula:C25H18F3N3O4SForma y color:SolidPeso molecular:513.49PMMB-187
CAS:PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.Fórmula:C27H23BrN2O6S2Forma y color:SolidPeso molecular:615.52STAT6-IN-13
CAS:STAT6-IN-13 (Compound 22) is a STAT6 inhibitor with an IC50 value of ≤300 nM, demonstrating weak inhibition of STAT3. It can be utilized for research in cancer, inflammation, and immunology.Fórmula:C32H33F2N4O6PSPeso molecular:670.66STAT3-IN-8
CAS:"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."Fórmula:C19H7F7N2O3Pureza:98%Forma y color:SolidPeso molecular:444.26KT621 Analog 2
CAS:KT621 Analog 2 also measured the DC50 value of STAT6 to be > 1 µM through the Meso Scale Discovery Assay (MSDA) method. This detection was derived after culturing the human cell line A549 at 37°C for 24 hours.Fórmula:C55H67N11O6SForma y color:SolidPeso molecular:1010.26
