
MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 892 productos de "MAPK"
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Cot inhibitor-2
CAS:Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.Fórmula:C26H25Cl2FN8Pureza:99.85%Forma y color:SolidPeso molecular:539.43Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Fórmula:C20H17FO2SPureza:99.35%Forma y color:SolidPeso molecular:340.41ZINC09659342
CAS:<p>ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).</p>Fórmula:C23H15F3N2O4Forma y color:SolidPeso molecular:440.37SW-034538
CAS:SW-034538 is a TAO2 inhibitor (IC 50= 300 nM).Fórmula:C18H20N4O3S2Forma y color:SolidPeso molecular:404.51Tpl2 Kinase Inhibitor 1
CAS:Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.Fórmula:C21H14ClFN6Pureza:98%Forma y color:SolidPeso molecular:404.83HPK1-IN-26
CAS:HPK1-IN-26, from WO2021254118A1, is a potent dual HPK1/GLK inhibitor for studying animal infections.Fórmula:C19H21N5OSForma y color:SolidPeso molecular:367.47p38 MAP Kinase Inhibitor IV
CAS:p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.Fórmula:C12H4Cl6O4SForma y color:SolidPeso molecular:456.94MW108
CAS:MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.Fórmula:C21H19ClN4Forma y color:SolidPeso molecular:362.86Tpl2-IN-I
CAS:Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.Fórmula:C21H14ClFN6Pureza:98%Forma y color:SolidPeso molecular:404.83NSC1011
CAS:NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).Fórmula:C23H18N2O3Pureza:98%Forma y color:SolidPeso molecular:370.4AZD6703 free base
CAS:AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).Fórmula:C24H27N5O2Forma y color:SolidPeso molecular:417.5Kobe2601
CAS:Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.Fórmula:C13H10FN5O4SPureza:98%Forma y color:SolidPeso molecular:351.31GSK329
CAS:GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.Fórmula:C19H14Cl2F3N5O2Pureza:98%Forma y color:SolidPeso molecular:472.25HCI-2184
CAS:HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.Fórmula:C23H28ClN7O2SPureza:98%Forma y color:SolidPeso molecular:502.03GSK649A
CAS:GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Fórmula:C15H12ClFN6OSPureza:98%Forma y color:SolidPeso molecular:378.81CP-281384
CAS:CP-281384 is a potent, p38alpha-selective inhibitor.Fórmula:C18H14F2N4OPureza:98%Forma y color:SolidPeso molecular:340.33KRAS G12C inhibitor 29
CAS:KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.Fórmula:C23H21ClFN5O2Forma y color:SolidPeso molecular:453.9SX 011
CAS:SX 011 is a p38α inhibitor.Fórmula:C26H27ClFN3O3Pureza:98%Forma y color:SolidPeso molecular:483.96KRAS G12C inhibitor 42
CAS:KRAS G12C inhibitor 42 targets KRAS G12C for potential cancer therapy. (Patent WO2020146613A1, compound 10)Fórmula:C33H34FN7O2Forma y color:SolidPeso molecular:579.67RBC6
CAS:RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.Fórmula:C16H14Cl2N4O2Pureza:98%Forma y color:SolidPeso molecular:365.21
