MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 924 productos para "MAPK".
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Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Fórmula:C20H17FO2SPureza:99.35%Forma y color:SolidPeso molecular:340.41PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Fórmula:C24H22F2N6O3SPureza:99.51% - 99.66%Forma y color:SolidPeso molecular:512.532KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Fórmula:C32H36ClN7O2Pureza:98%Forma y color:SolidPeso molecular:586.13Tpl2-IN-I
CAS:Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.Fórmula:C21H14ClFN6Pureza:98%Forma y color:SolidPeso molecular:404.83p38α inhibitor 2
CAS:P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.Fórmula:C27H33N5O3Forma y color:SolidPeso molecular:475.5826(R)-PD 0325901CL
CAS:(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.Fórmula:C16H14ClF2IN2O4Forma y color:SolidPeso molecular:498.65MW108
CAS:MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.Fórmula:C21H19ClN4Forma y color:SolidPeso molecular:362.86NSC-70220
CAS:SOS1-IN-1 is an inhibitor of SOS1.Fórmula:C22H15NO2Pureza:98%Forma y color:SolidPeso molecular:325.36MNK1/2-IN-5
CAS:MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.Fórmula:C17H16N4O2Pureza:99.14%Forma y color:SolidPeso molecular:308.33Tpl2 Kinase Inhibitor 1
CAS:Tpl2 Kinase Inhibitor 1 is a potent, reversible, and highly selective ATP-competitive inhibitor of Tpl2 (MAP3K8/COT) serine/threonine kinase.Fórmula:C21H14ClFN6Pureza:98.59%Forma y color:Yellow SolidPeso molecular:404.83MEK inhibitor
CAS:MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.Fórmula:C26H26N4O2Pureza:97.48%Forma y color:SolidPeso molecular:426.5102RAS inhibitor Abd-7
CAS:RAS inhibitor Abd-7 is a RAS binding inhibitor, which can block the RAS signal pathway.Fórmula:C23H25N3O3Forma y color:White SolidPeso molecular:391.4629SOS1 activator 1
CAS:SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).Fórmula:C26H32ClFN6Forma y color:SolidPeso molecular:483.02Quazinone
CAS:Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.Fórmula:C11H10ClN3OForma y color:SolidPeso molecular:235.67RAF-IN-1
CAS:RAF-IN-1 inhibits cRAF, BRAF and BRAFV600E, with GI50 3.4 and 2.9 nM in mutant cell lines.Fórmula:C26H22F3N3O4Pureza:99.62%Forma y color:White SolidPeso molecular:497.47KRAS inhibitor-4
CAS:KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.Fórmula:C30H39ClN8OPureza:98%Forma y color:SolidPeso molecular:563.14Anti-inflammatory agent 33
CAS:Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.Fórmula:C22H15N3O5SForma y color:SolidPeso molecular:433.44RSK2-IN-3
CAS:RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.Fórmula:C24H26N4O5Forma y color:SolidPeso molecular:450.49MLKL-IN-5
CAS:MLKL-IN-5 is a potent MLKL inhibitor blocking necroptosis signaling.Fórmula:C18H20N6O4SPureza:98.77%Forma y color:Pink SolidPeso molecular:416.45KRAS inhibitor-3
CAS:KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.Fórmula:C25H27N5OForma y color:SolidPeso molecular:413.5148
